3-Benzyl-3-hy­droxy-2-phenyl-3H-indole 1-oxide

The asymmetric unit of the title compound, C21H17NO2, contains two crystallographically independent mol­ecules of similar geometry. The indole ring systems form dihedral angles of 8.30 (5) and 9.58 (5)° with the attached phenyl rings, and 56.96 (5) and 57.68 (5)° with the aromatic rings of the respective benzyl groups. The mol­ecular conformations are stabilized by intra­molecular C—H⋯O hydrogen bonds. In the crystal structure, centrosymmetrically related pairs of mol­ecules are linked into dimers through pairs of inter­molecular O—H⋯O hydrogen bonds, generating 12-membered rings with R 2 2(12) motifs. The dimers are further linked into a three-dimensional network by C—H⋯O inter­actions

Cardiac resynchronization therapy-defibrillator improves long-term survival compared with cardiac resynchronization therapy-pacemaker in patients with a class IA indication for cardiac resynchronization therapy: Data from the Contak Italian Registry

Aims In candidates for cardiac resynchronization therapy (CRT), the choice between pacemaker (CRT-P) and defibrillator (CRT-D) implantation is still debated. We compared the long-term prognosis of patients who received CRT-D or CRT-P according to class IA recommendations of the European Society of Cardiology (ESC) and who were enrolled in a multicentre prospective registry. Methods and results A total of 620 heart failure patients underwent successful implantation of a CRT device and were enrolled in the Contak Italian Registry. This analysis included 266 patients who received a CRT-D and 108 who received a CRT-P according to class IA ESC indications. Their survival status was verified after a median follow-up of 55 months. During follow-up, 73 CRT-D and 44 CRT-P patients died (rate 6.6 vs. 10.4%/year; log-rank test, P = 0.020). Patients receiving CRT-P were predominantly older, female, had no history of life-threatening ventricular arrhythmias, and more frequently presented non-ischaemic aetiology of heart failure, longer QRS durations, and worse renal function. However, the only independent predictor of death from any cause was the use of CRT-P (hazard ratio, 1.97; 95% confidence interval, 1.21–3.16; P = 0.007). Conclusion The implantation of CRT-D, rather than CRT-P, may be preferable in patients presenting with current class IA ESC indications for CRT. Indeed, CRT-D resulted in greater long-term survival and was independently associated with a better prognosis

Die Malaria von Rom und die alte Drainage der römischen Hügel

von Conrad Tommasi-Crudeli. In's Dt. übers. von Adolf Schuste

Studien über die ursache des wechselfiebers und über die natur der malaria.

Extract from the Archiv für experimentelle pathologie und pharmakologie. bd. 11.Caption title.Mode of access: Internet

Studi preliminari su alcune alterazioni fisiologiche in olivi colpiti da Co.Di.R.O.

Il presente lavoro raccoglie dati preliminari su alcune alterazioni fisiologiche rilevate nelle piante di olivo affetteda Co.di.r.o. (Complesso del disseccamento rapido dell’olivo, malattia rinominata “Sindrome del disseccamento rapidodell’olivo o.Q.d.S.: dall’inglese olive Quick decline Syndrome). Le piante affette sono caratterizzate dalla presenza di bru-scatura (disseccamento della parte apicale e/o marginale) e seccumi di rami isolati, piccole branche o dell’intera chioma. Lefoglie asintomatiche di piante con conclamati sintomi di malattia hanno mostrato, rispetto a quelle raccolte da piante sane,una riduzione (48%) del contenuto in fenoli e un incremento (3 volte) della capacità antiossidante. danni alle membranecellulari nei tessuti fogliari delle piante infette sono presumibili dai valori di malondialdeide (incrementi di circa 6 volte),proporzionale al grado di perossidazione lipidica, e comprovati da una perdita di elettroliti intorno al 60%

POLYPHENOL CONSTITUENTS AND ANTIOXIDANT ACTIVITY OF GRAPE POMACE EXTRACTS FROM FIVE SICILIAN RED GRAPE CULTIVARS.

The methanolic extracts (MeOH) obtained from de-stemmed grape pomace samples of five Sicilian red grape cultivars (Nero d’Avola-NA, Nerello Mascalese-NM, Nerello Cappuccio-NC, Frappato-FR and Cabernet Sauvignon-CS) were evaluated for their DPPHand ABTS radical scavenging capacity, and submitted to HPLC–UV–DAD and HPLC–MS–ESI analysis to determine the main polyphenolic constituents, namely anthocyanins and flavonols. All the MeOH extracts showed significant antioxidant activity, with some differences between the two methods employed. The NM sample was the most active in both tests. A large variability in the total anthocyanin (TA) and flavonol (TF) contents of the MeOH extracts, as well as in the quantitative distribution of the single anthocyanins and flavonols was observed. Statistically insignificant correlations between the TA + TF content and antioxidant activity, as measured by DPPHand ABTSmodel systems (r2 = 0.0607, P > 0.05; r2 = 0.3471, P > 0.05), were established, but the most active sample, NM, showed the highest content of anthocyanins including a free catechol moiety in their structure

A patient-specific computational fluid dynamics model of the left atrium in atrial fibrillation: Development and initial evaluation

Atrial fibrillation (AF) is associated to a five-fold increase in the risk of stroke and AF strokes are especially severe. Stroke risk is connected to several AF related morphological and functional remodeling mechanisms which favor blood stasis and clot formation inside the left atrium. The goal of this study was therefore to develop a patient-specific computational fluid dynamics model of the left atrium which could quantify the hemodynamic implications of atrial fibrillation on a patient-specific basis. Hereto, dynamic patient-specific CT imaging was used to derive the 3D anatomical model of the left atrium by applying a specifically designed image segmentation algorithm. The computational model consisted in a fluid governed by the incompressible Navier-Stokes equations written in the Arbitrary Lagrangian Eulerian (ALE) frame of reference. In this paper, we present the developed model as well as its application to two AF patients. These initial results confirmed that morphological and functional remodeling processes associated to AF effectively reduce blood washout in the left atrium, thereby increasing the risk of clot formation. Our analysis is a step forward towards improved patient-specific stroke risk stratification and therapy planning