15 research outputs found
Identification of impact aroma compounds in Eugenia uniflora L. (Brazilian Pitanga) leaf essential oil
The leaf essential oil of Eugenia uniflora L. (Myrtaceae) was extracted by Clevenger apparatus and analysed by gas chromatography-mass spectrometry (GC-MS). The leaves were collected and immediately extracted for five consecutive days at 9:00 am and 2:00 pm. No variance in the oil yields were observed in the period. Furanodiene and its rearrangement product, furanoelemene (or curzerene, 50.2%), beta-elemene (5.9%) and alpha-cadinol (4.7%) were identified as the most abundant compounds. GC-Olfatometry (GC-O) associated to Aroma Extract Dilution Analysis (AEDA) allowed the identification of nine active aroma compounds, where furanodiene (along with furanoelemene, FD 1024), beta-elemene (FD 256) and (E,E)-germacrone (FD 256) were characterized as the main impact aroma compounds in the odor of this essential oil. Those substances were collected through a sniffing port adapted on the GC allowing to obtain a typical essence of pitanga as indicated by comparative olfatometric analysis
Constituintes quĂmicos voláteis das flores e folhas do pau-brasil (Caesalpinia echinata, Lam.)
Multidisciplinary scientific cruise to the Rio Grande Rise
The full text of this article can be freely accessed on the publisher's website
Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
Summary
Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally.
Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies
have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of
the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income
countries globally, and identified factors associated with mortality.
Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to
hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis,
exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a
minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical
status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary
intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause,
in-hospital mortality for all conditions combined and each condition individually, stratified by country income status.
We did a complete case analysis.
Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital
diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal
malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome
countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male.
Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3).
Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income
countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups).
Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome
countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries;
p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients
combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11],
p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20
[1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention
(ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety
checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed
(ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of
parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65
[0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality.
Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome,
middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will
be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger
than 5 years by 2030
Constituintes quĂmicos voláteis das flores e folhas do pau-brasil (Caesalpinia echinata, Lam.)
The volatile constituents obtained from a static cryogenic headspace of Caesalpinia echinata Lam. (Leguminosae) showed E-beta-ocimene as the major compound (57.2%), beside other monoterpenes, C6 derivatives like n-hexanal and (E)-2-hexenal and nitrogen compounds such as indole and methyl anthranilate. From the essential oil of the leaves obtained by hydrodistillation in a Clevenger apparatus, (E)-3-hexen-1-ol was identified as the major constituent while phenolic compounds were the most representative class of secondary metabolites
Pharmacological action of Syxygium cumini (L.) Skeels
Os produtos de origem vegetal, apĂłs longo perĂodo de esquecimento, ganharam novo interesse numa tentativa de se voltar Ă natureza para a prevenção e o tratamento de doenças, principalmente aquelas nĂŁo tratadas pela medicina tradicional. Syzygium cumini (L.) Skeels, popularmente conhecido como jambolĂŁo, Ă© uma planta muito conhecida por várias ações farmacolĂłgicas tanto pelo uso popular como cientĂfico. Na pesquisa realizada, foram descritas atividades antidiabĂ©ticas, antidiarrĂ©icas, antiinflamatĂłrias, antioxidantes e antimicrobianas entre outras.Natural products have received new interest recently, maybe in men's attempt to turn into the nature for the prevention and the relief of diseases, mainly because of those untreated by the traditional medicine. Syzygium cumini (L.) Skeels, popularly known as "jambolĂŁo", is a well-known plant by several pharmacological actions so much in the popular use as in the scientific literature. In this search antidiabetic, anti-diarrhoeal, anti-inflammatory, antioxidant and antimicrobial activities of "jambolĂŁo" were described, among other actions.Colegio de FarmacĂ©uticos de la Provincia de Buenos Aire
Pharmacological action of Syxygium cumini (L.) Skeels
Os produtos de origem vegetal, apĂłs longo perĂodo de esquecimento, ganharam novo interesse numa tentativa de se voltar Ă natureza para a prevenção e o tratamento de doenças, principalmente aquelas nĂŁo tratadas pela medicina tradicional. Syzygium cumini (L.) Skeels, popularmente conhecido como jambolĂŁo, Ă© uma planta muito conhecida por várias ações farmacolĂłgicas tanto pelo uso popular como cientĂfico. Na pesquisa realizada, foram descritas atividades antidiabĂ©ticas, antidiarrĂ©icas, antiinflamatĂłrias, antioxidantes e antimicrobianas entre outras.Natural products have received new interest recently, maybe in men's attempt to turn into the nature for the prevention and the relief of diseases, mainly because of those untreated by the traditional medicine. Syzygium cumini (L.) Skeels, popularly known as "jambolĂŁo", is a well-known plant by several pharmacological actions so much in the popular use as in the scientific literature. In this search antidiabetic, anti-diarrhoeal, anti-inflammatory, antioxidant and antimicrobial activities of "jambolĂŁo" were described, among other actions.Colegio de FarmacĂ©uticos de la Provincia de Buenos Aire
Caracterização das MatrĂculas dos Alunos com Transtorno do Espectro do Autismo por Regiões Brasileiras
Coxins interfalangeanos sobre paquidermodactilia Interphalangeal pads on pachydermodactyly
Coxins interfalangeanos sĂŁo nodulações ceratĂłsicas, de limites precisos, com aproximadamente um centĂmetro de diâmetro, geralmente sobre as articulações interfalangenas das mĂŁos. A paquidermodactilia Ă© uma tumefação uniforme da pele que ocorre nas falanges proximais das mĂŁos. É relatado o caso de um jovem com associação de paquidermodactilia e coxins interfalangeanos, fato nĂŁo encontrado na literatura mĂ©dica. Embora haja descrição que considera serem essas manifestações diversas da mesma doença, acredita-se que sejam entidades distintas. O ato compulsivo de atritar a pele parece ser o denominador comum mais aceito para justificar as duas doenças. Os autores postulam que o coxim interfalangeano seria uma resposta epidĂ©rmica, enquanto a paquidermodactilia, uma resposta dĂ©rmica a um mesmo fator traumático sobre a pele. O paciente foi tratado com infiltração intralesional de triancinolona, com melhora clĂnica expressiva das duas manifestações.<br>Knuckle pads are keratotic nodulations within precise limits and approximately one centimeter in diameter, usually on the interphalangeal joints of the hands. Pachydermodactyly is a uniform swelling of the skin occurring in the proximal phalanges of the hands. A case involving a young man suffering from several knuckle pad lesions concomitant with pachydermodactyly was studied. This association has not been previously described in the literature. Although it has been reported that both conditions are different manifestations of the same disease, they are believed to be distinct disorders. The compulsive act of rubbing the skin seems to be a common denominator mostly accepted as the cause of both diseases. The authors affirm that knuckle pads may be acquired as an epidermal response, while pachydermodactyly, is a dermal response to the same traumatic factor to the skin. The patient was treated with intralesional infiltration of triamcinolone resulting in a remarkable clinical improvement in both manifestations