The Contract Disclosure Mandate and Earnings Management under External Scrutiny

This paper studies the effects of mandating compensation disclosure on executive incentive contracts, and the ensuing effects on earnings management, and shareholders' and social welfare. We develop a moral hazard model with multiple principal-agent pairs facing an external inspector who allocates resources across firms to uncover and penalize earnings management. Contract disclosure confers principals with a first-mover advantage, allowing them to design the contract anticipating the inspector's reaction. However, it may also exacerbate a coordination problem among principals, as they do not consider externalities on other principals caused by the effects of their contract choices on the inspector's scrutiny allocation. We find that, if the penalty the inspector imposes on executives is relatively harsher than that imposed on shareholders, contracts become more strongly contingent on reported earnings, earnings are more severely manipulated, and social welfare increases with contract disclosure. However, disclosure improves shareholders' welfare only if the scrutiny resources available to the inspector are not strongly constrained

The Grizzly, April 16, 2020

Students React to Room and Board Adjustments • Biden my Time? I\u27d Rather not be • Coronavirus is Another Obstacle on the Comeback Trail for Pitcher Nick DeFeohttps://digitalcommons.ursinus.edu/grizzlynews/1962/thumbnail.jp

Benchmarks for flexible and rigid transcription factor-DNA docking

<p>Abstract</p> <p>Background</p> <p>Structural insight from transcription factor-DNA (TF-DNA) complexes is of paramount importance to our understanding of the affinity and specificity of TF-DNA interaction, and to the development of structure-based prediction of TF binding sites. Yet the majority of the TF-DNA complexes remain unsolved despite the considerable experimental efforts being made. Computational docking represents a promising alternative to bridge the gap. To facilitate the study of TF-DNA docking, carefully designed benchmarks are needed for performance evaluation and identification of the strengths and weaknesses of docking algorithms.</p> <p>Results</p> <p>We constructed two benchmarks for flexible and rigid TF-DNA docking respectively using a unified non-redundant set of 38 test cases. The test cases encompass diverse fold families and are classified into easy and hard groups with respect to the degrees of difficulty in TF-DNA docking. The major parameters used to classify expected docking difficulty in flexible docking are the conformational differences between bound and unbound TFs and the interaction strength between TFs and DNA. For rigid docking in which the starting structure is a bound TF conformation, only interaction strength is considered.</p> <p>Conclusions</p> <p>We believe these benchmarks are important for the development of better interaction potentials and TF-DNA docking algorithms, which bears important implications to structure-based prediction of transcription factor binding sites and drug design.</p

The Grizzly, April 2, 2020

The Canvas Commencement? • Film Festival Adapts to Online World • The Circle Brazil and Demystifying the Foreign • Profile: Hailey DiCiccohttps://digitalcommons.ursinus.edu/grizzlynews/1960/thumbnail.jp

Effect of simulated gastrointestinal digestion and fermentation on polyphenolic content and bioactivity of brown seaweed phlorotannin-rich extracts

Although phlorotannins, TP levels and antioxidant power of the extracts were strongly reduced after in vitro digestion and fermentation, their anti-genotoxic activity and cell growth inhibitory effect in colon HT-29 cells was maintained and enhanced. HMW was the most effective fraction, indicating that the high molecular weight phlorotannins potentially exert a stronger beneficial effect in the colon

The Nucleosome-Remodeling ATPase ISWI Is Regulated by Poly-ADP-Ribosylation

ATP-dependent nucleosome-remodeling enzymes and covalent modifiers of chromatin set the functional state of chromatin. However, how these enzymatic activities are coordinated in the nucleus is largely unknown. We found that the evolutionary conserved nucleosome-remodeling ATPase ISWI and the poly-ADP-ribose polymerase PARP genetically interact. We present evidence showing that ISWI is target of poly-ADP-ribosylation. Poly-ADP-ribosylation counteracts ISWI function in vitro and in vivo. Our work suggests that ISWI is a physiological target of PARP and that poly-ADP-ribosylation can be a new, important post-translational modification regulating the activity of ATP-dependent nucleosome remodelers

The Grizzly, October 3, 2019

New Play Inspired by Ursinus\u27 History • Dr. Shuru Helps Launch Latinx Book Club • Life as an International Student at Ursinus • Librarian Creates New Myrin Escape Room • Opinions: Slouching Towards Paradise: A Bolder Bachelor ?; Students Should Have a Say in Colleges\u27 Endowment Investments • Volleyball Looks to get Back on Track • Field Hockey Extends Win Streak to Five Gameshttps://digitalcommons.ursinus.edu/grizzlynews/1590/thumbnail.jp

The Grizzly, March 15, 2018

Ursinus Evacuates Main Street Houses as Winter Storm Cuts Collegeville Power • Blomberg Hires New Special Assistant • Student Government Holds Elections This Week • SASA to Host Philly Lion Dancers • Clybourne Park Comes to Ursinus • Opinions: Diversity Monologues Reflect Lack of Racial Diversity; Students Should Use Art as a Form of Political Protest • Softball Wins Seven Straight in Florida • Champions: Women\u27s Swimming 5-peatshttps://digitalcommons.ursinus.edu/grizzlynews/1640/thumbnail.jp

The Grizzly, April 23, 2020

Keeping up in the Quarantine • The Career and Post-Graduate Development Office Adjusts to Online Campus • New UCSG President Elected • Student Literary Magazine, The Lantern, Launches Online • Tiger King and the Spectacle of the Redneck • Now Batting for the Ursinus College Bears, Number 21, Alex Mummehttps://digitalcommons.ursinus.edu/grizzlynews/1963/thumbnail.jp

The Grizzly, November 14, 2019

UC\u27s Four Watson Fellowship Finalists • #Fight4Her Activists Visit Campus • Exxon Mobil\u27s Role in Climate Research • \u2719 UC Grad Named Bear Tracks Fellow • Meet Student-run Group Escape Velocity • Opinion: A Coup by any Other Name: On Bolivia • First-year QB Shines Against McDaniel • Field Hockey Concludes Postseason Runhttps://digitalcommons.ursinus.edu/grizzlynews/1595/thumbnail.jp