Robert Nelson\u27s \u3cem\u3eA Room with a View\u3c/em\u3e: The Creation of a Contemporary Opera

My recent engagement as music director and conductor of Robert Nelson’s A Room with a View (1992, rev. 2004) has offered me the valuable opportunity to work on an opera side by side with its composer. The purpose of this dissertation is to reconstruct the various stages of the process of creation, interpretation, and performance of a contemporary opera, addressing aspects of the collaboration between the composer and the conductor. The methodology used in my research is based primarily on direct observation and interview. The investigation is conducted from the perspective of a “participant-observer,” due to my personal involvement in the project, as music director and conductor first, and then as interviewer and researcher. The document will be organized in three sections: - the first chapter will establish the context and specific features of my research, providing a scholarly background in relation to the study of the relationship between composer and conductor; - the second chapter will focus on the process of composition in all its stages. I have defined this as the “extended creative process” of A Room with a View; - the third chapter will discuss the Michigan State University production of the opera, considering several aspects of the artistic collaboration between Robert Nelson and me, as well as my involvement in the process as conductor. Through my research, I wish to provide useful insight into the crucial aspects of the composition and the production of new music. In addition, the project aims to offer a fresh contribution to the investigation of the relationship between composers and interpreters, and perhaps could provide some background reference for an interrogation about the current state and the future of American opera

Endometrioma of the Abdominal Wall after Caesarean Section

Background:Endometrial cell implantation after abdominal surgery, mainly after caesarean section, may result in formation of endometrioma, which is usually described to be of various sizes, and adjacent to the surgical scar. Case:A 36-year old woman complaining of a mass of the abdominal wall with pain during the menstrual period, with a caesarean section 5 years earlier, presented a rounded tumour not contiguous to the Pfannenstiel’s laparotomy scar, of hard consistence, fixed and adherent to the deep abdominal wall structures, located on the left paramedian epigastric region. Magnetic Resonance imaging showed the nodule, involving the deep layers of the abdominal wall and the distance from the laparotomic scar. Surgical removal was performed with wide excision of the lesion, causing a large wall defect. After histological con-firmation (endometriosis) by frozen section, reconstruction of the abdominal wall required prolene mesh grafting. After twelve months the patient is healthy. Conclusion: When abdominal wall endometrioma is located distant from the scar, perhaps more frequently after Pfannenstiel’s laparotomic inci-sion, the differential diagnosis may be more difficult and MRI can help diffe-rentiating many of these lesions, and histological confirmation should be ob-tained intraoperatively, by frozen section, to allow an oncological resection if required

Mitochondrial caseinolytic protease p: A possible novel prognostic marker and therapeutic target in cancer

Caseinolytic protease P (ClpP) is a mitochondrial serine protease. In mammalian cells, the heterodimerization of ClpP and its AAA+ ClpX chaperone results in a complex called ClpXP, which has a relevant role in protein homeostasis and in maintaining mitochondrial functionality through the degradation of mitochondrial misfolded or damaged proteins. Recent studies demonstrate that ClpP is upregulated in primary and metastatic human tumors, supports tumor cell proliferation, and its overexpression desensitizes cells to cisplatin. Interestingly, small modulators of ClpP activity, both activators and inhibitors, are able to impair oxidative phosphorylation in cancer cells and to induce apoptosis. This review provides an overview of the role of ClpP in regulating mitochondrial functionality, in supporting tumor cell proliferation and cisplatin resistance; finally, we discuss whether this protease could represent a new prognostic marker and therapeutic target for the treatment of cancer

Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications.

Uterine cervical cancer is the fourth most frequent gynecological tumor worldwide. The tumor microenvironment of cervical cancer is the result of persistent high-risk human papillomavirus infection together with stromal activation of estrogen receptor alpha and the pro-angiogenic and pro-inflammatory activity of immune cells, mainly T-helper 17 cells and tumor-associated macrophages. Therapeutic management (e.g., immunotherapy, especially in advanced cases) may be influenced by the translational implications of tumoral stroma crosstalk and an abundance of tumor-infiltrating lymphocytes within the tumor microenvironment. The prognosis of cervical cancer is inversely correlated with microvessel density, making anti-angiogenic strategies with agents such as bevacizumab crucial for improving both progression-free survival and overall survival in patients with advanced and recurrent tumors

Mitofusin-2 Down-Regulation Predicts Progression of Non-Muscle Invasive Bladder Cancer

Identification of markers predicting disease outcome is a major clinical issue for non-muscle invasive bladder cancer (NMIBC). The present study aimed to determine the role of the mitochondrial proteins Mitofusin-2 (Mfn2) and caseinolytic protease P (ClpP) in predicting the outcome of NMIBC. The study population consisted of patients scheduled for transurethral resection of bladder tumor upon the clinical diagnosis of bladder cancer (BC). Samples of the main bladder tumor and healthy-looking bladder wall from patients classified as NMIBC were tested for Mfn2 and ClpP. The expression levels of these proteins were correlated to disease recurrence, progression. Mfn2 and ClpP expression levels were significantly higher in lesional than in non-lesional tissue. Low-risk NMIBC had significantly higher Mfn2 expression levels and significantly lower ClpP expression levels than high-risk NMIBC; there were no differences in non-lesional levels of the two proteins. Lesional Mfn2 expression levels were significantly lower in patients who progressed whereas ClpP levels had no impact on any survival outcome. Multivariable analysis adjusting for the EORTC scores showed that Mfn2 downregulation was significantly associated with disease progression. In conclusion, Mfn2 and ClpP proteins were found to be overexpressed in BC as compared to non-lesional bladder tissue and Mfn2 expression predicted disease progression

TOUGH2Viewer tutorial

TOUGH2Viewer is a Java program capable of displaying unstructured (Voronoi complying) grids, locally refined and structured grids (complying with the MESHMAKER iTOUGH2 format). In particular, TOUGH2Viewer allows to navigate through a 3D grid compatible with the iTOUGH2 data file format and see: (1) the thermodynamic variables and the material (namely, petrophysical properties) of each block; (2) maps of isovalues (2D) of all thermodynamic variables; (3) isosurfaces (3D) of all thermodynamic variables; (4) flows of mass and heat between blocks; (5) spatial profiles of thermodynamic variables, of a selected set of blocks, long a Cartesian directions; (6) time plot of thermodynamic variables of a selected block. All commands to manage a 3D visualization (zooming, pan, rotations) are CAD complying

Primary Vaginal Carcinoma Arising on Cystocele Mimicking Vulvar Cancer.

Abstract Background Primary vaginal carcinoma is a rare gynaecological tumour representing 1%–3% of all gynaecologic cancers. Several studies report increased vaginal cancer risk associated with genital prolapse following the occurrence of inflammatory lesions or decubitus ulcers. Case We report the rare case of an 82-year-old woman with primary squamous cell carcinoma arising from vaginal wall prolapse. Vaginal carcinoma was suspected during gynaecological examination for vulvar bleeding. A wide local excision was performed and pathologic examination revealed a primary squamous cell carcinoma of the vagina. Conclusion Persistent genital prolapse may be at risk for vaginal carcinoma, and cytological and a colposcopic assessments are essential to identify patients who require diagnostic biopsy