Fertilização In Vitro: Mais de 4 Milhões de Crianças Nascidas e Um Prêmio Nobel

Em 1978, nasceu Louise Brown, o primeiro bebê de proveta. Este nascimento histórico foi o resultado de pesquisas do biólogo Robert Edwards e do ginecologista Patrick Steptoe (1). Em 2010, Edwards recebeu o premio Nobel de Medicina/Fisiologia, pela importância desta técnica para a humanidade. Este artigo revisa as etapas envolvidas na fertilização in vitro (FIV), as dificuldades dos pioneiros, as soluções encontradas e os procedimentos clínicos utilizados atualmente

Insulin receptor tyrosine kinase activity in colon carcinoma

Colon carcinoma is the most common tumor of the gastrointestinal tract. According to some investigators, insulin, epidermal growth factor (EGF) and insulin-like growth factor I (IGF-I) may be involved in the neoplastic proliferation. Insulin-binding and receptor tyrosine kinase activity were investigated in colon carcinomas and in normal colons. The insulin receptor concentration, as shown by binding assays, was 17.4 ± 4.3 fmol/J.Lg in normal colon and 29.69 ± 9.4 fmol/ J.Lg in colon carcinoma. Nevertheless, the insulin affinity of the receptor was similar in both groups (Kd ::: 1 nM). Both normal and neoplastic colon showed phosphorylation of the insulin receptor. The electrophoretic migration of the B-subunit of the insulin receptors purified from colon carcinomas was similar to that of normal colon and both tissues demonstrated an insulin-dependent autophosphorylation. The receptor tyrosine kinase activity was measured by the incorporation of[gamma32P]ATP into the B-subunit. The basal and the insulin-stimulated tyrosine kinase activities were significantly higher in colon carcinomas compared to normal colon tissues (2.2 and 1.6 times, respectively). Understanding the metabolism of neoplastic cells may contribute to the development of prevention strategies as well as new therapies. It is now necessary to study other steps of the insulin signal transduction pathway, such as insulin receptor substrate 1 phosphorylation

Dor Pélvica e Dispareunia : relato de um caso de mesotelioma cístico benigno

Benign cystic mesothelioma is a rare tumor originated from mesenchymal cells of the abdominal and pelvic peritoneum. This rare tumor should be considered in the differential diagnosis of young women presenting with abdominal pain and a multicystic abdominal mass.O mesotelioma cístico benigno é um tumor raro originado de células mesenquimais do peritônio abdominal e pélvico. Este tumor raro deve ser considerado no diagnóstico diferencial de mulheres jovens apresentando dor abdominal e massa abdominal multicística

PELVIC PAIN AND DISPAREUNIA: A BENIGN CYSTIC MESOTHELIOMA CASE REPORT

Benign cystic mesothelioma is a rare tumor originated from mesenchymal cells of the abdominal and pelvic peritoneum. This rare tumor should be considered in the differential diagnosis of young women presenting with abdominal pain and a multicystic abdominal mass.Keywords: Benign cystic mesothelioma; pelvic pain; dispareuni