Understanding the links between agriculture and health:

CONTENTS: 1.Overview / Corinna Hawkes and Marie T. Ruel; 2. Agriculture, Food, and Health: Perspectives on a Long Relationship / Tim Lang; 3. Agricultural Technology and Health / Michael Lipton, Saurabh Sinha, and Rachel Blackman; 4. Agriculture and Nutrition Linkages: Old Lessons and New Paradigms / Corinna Hawkes and Marie T. Ruel; 5. Agriculture, Food Safety, and Foodborne Diseases / Ewen C. D. Todd and Clare Narrod; 6. Agriculture, Malaria, and Water-Associated Diseases / Clifford M. Mutero, Matthew McCartney, and Eline Boelee; 7. Agriculture and HIV/AIDS / Stuart Gillespie; 8. Occupational Health Hazards of Agriculture / Donald Cole; 9. Livestock and Health / Maria Angeles O. Catelo; 10. Fish and Health / Nanna Roos, Md. Abdul Wahab, Chhoun Chamnan, and Shakuntala Haraksingh Thilsted; 11. Agroforesty, Nutrition, and Health / Brent Swallow and Sophie Ochola; 12. Agrobiodiversity, Nutrition, and Health / Timothy Johns, Ifeyironwa Francisca Smith, and Pablo B. Eyzaguirre; 13. Urban Agriculture and Health / Diana Lee-Smith and Gordon Prain; 14. Agriculture, Environment, and Health: Toward Sustainable Solutions / Rachel Nugent and Axel Drescher; 15. Agriculture and Health in the Policymaking Process / Todd Benson; 16. Opportunities for Improving the Synergies between Agriculture and Health / Robert Bos.Agriculture, Agroforestry, Health and nutrition, Agricultural technology, Food safety, Malaria, Diseases, HIV/AIDS, Sustainability, Biodiversity, Agrobiodiversity, Environmental management,

Perceived Community Cohesion and the Stress Process in Youth

Using survey data from two youth samples, one rural and one urban, we examine the role and significance of perceived community cohesion in the stress process. In particular, we assess the extent to which community attachment and detachment are related to depressed mood, problem substance use, and delinquency net of social statuses, stress exposure, and personal attributes. In addition, we explore the degree to which those dimensions of community cohesion explain or condition the links between the above stress-process components (e.g., social statuses, stress exposure, and personal attributes) and well-being. We find remarkably similar results across samples: community attachment is related to lower odds of problem substance use and delinquency; community detachment is related to higher levels of depressed mood, problem substance use, and delinquency; and community attachment buffers the link between stress and problem substance use. With respect to depressed mood, however, the rural youth show greater vulnerability to stress than the urban youth and unique benefits from community attachment compared to the latter. Our findings highlight the roles of community attachment and detachment in the stress process and underscore the importance of each for youth well-being in rural and urban settings

Northern New Hampshire Youth in a Changing Rural Economy: A Ten-Year Perspective

The Coös Youth Study was a ten-year research project about growing up in a rural county undergoing transformative economic and demographic changes. The study addressed how these changes affected youths’ well-being as well as their plans to stay in the region, pursue opportunities elsewhere, permanently relocate, or return to their home communities with new skills and new ideas. In this report, the authors describe their findings and point to specific areas for action to support and retain North Country youth. The study was sponsored by the Neil and Louise Tillotson Fund of the New Hampshire Charitable Foundation as one component of the long-term research collaboration Tracking Change in the North Country

Interrupted Carbonyl‐Alkyne Metathesis

Carbonyl‐olefin metathesis and carbonyl‐alkyne metathesis represent established reactivity modes between carbonyls, alkenes, and alkynes under Lewis and Brønsted acid catalysis. Recently, an interrupted carbonyl‐olefin metathesis reaction has been reported that results in tetrahydrofluorenes via a distinct fragmentation of the reactive intermediate. We herein report the development of an analogous transformation interrupting the carbonyl‐alkyne metathesis reaction path resulting in dihydrofluorene products relying on Lewis acidic superelectrophiles as active catalytic species.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/1/adsc201901358.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/2/adsc201901358_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/153682/3/adsc201901358-sup-0001-misc_information.pd

Effect of Rare Fluctuations on the Thermalization of Isolated Quantum Systems

We consider the question of thermalization for isolated quantum systems after a sudden parameter change, a so-called quantum quench. In part icular we investigate the pre-requisites for thermalization focusing on the statistical properties of the time-averaged density matrix and o f the expectation values of observables in the final eigenstates. We find that eigenstates, which are rare compared to the typical ones sampled by the micro-canonical distribution, are responsible for the absence of thermalization of some infinite integrable models and play an important role for some non-integrable systems of finite size, such as the Bose-Hubbard model. We stress the importance of finite size effects for the thermalization of isolated quantum systems and discuss two alternative scenarios for thermalization, as well as ways to prune down the correct one.Comment: 4 pages, 2 figures + 8 pages, 4 figures of supplementary material; changed title, published versio

An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity

Dynamic small ubiquitin-like modifier (SUMO) linkages to diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome damage, hypoxia, or proteotoxicity. Defense against pathogen insult (often reliant upon host recognition of "non-self" nucleic acids) is also modulated by SUMO, but the underlying mechanisms are incompletely understood. Here, we used quantitative SILAC-based proteomics to survey pan-viral host SUMOylation responses, creating a resource of almost 600 common and unique SUMO remodeling events that are mounted during influenza A and B virus infections, as well as during viral innate immune stimulation. Subsequent mechanistic profiling focused on a common infection-induced loss of the SUMO-modified form of TRIM28/KAP1, a host transcriptional repressor. By integrating knockout and reconstitution models with system-wide transcriptomics, we provide evidence that influenza virus-triggered loss of SUMO-modified TRIM28 leads to derepression of endogenous retroviral (ERV) elements, unmasking this cellular source of "self" double-stranded (ds)RNA. Consequently, loss of SUMO-modified TRIM28 potentiates canonical cytosolic dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1. Intriguingly, although wild-type influenza A virus robustly triggers this SUMO switch in TRIM28, the induction of IFN-stimulated genes is limited unless expression of the viral dsRNA-binding protein NS1 is abrogated. This may imply a viral strategy to antagonize such a host response by sequestration of induced immunostimulatory ERV dsRNAs. Overall, our data reveal that a key nuclear mechanism that normally prevents aberrant expression of ERV elements (ERVs) has been functionally co-opted via a stress-induced SUMO switch to augment antiviral immunity.</p

Statics and dynamics of weakly coupled antiferromagnetic spin-1/2 ladders in a magnetic field

We investigate weakly coupled spin-1/2 ladders in a magnetic field. The work is motivated by recent experiments on the compound (C5H12N)2CuBr4 (BPCB). We use a combination of numerical and analytical methods, in particular the density matrix renormalization group (DMRG) technique, to explore the phase diagram and the excitation spectra of such a system. We give detailed results on the temperature dependence of the magnetization and the specific heat, and the magnetic field dependence of the nuclear magnetic resonance (NMR) relaxation rate of single ladders. For coupled ladders, treating the weak interladder coupling within a mean-field or quantum Monte Carlo approach, we compute the transition temperature of triplet condensation and its corresponding antiferromagnetic order parameter. Existing experimental measurements are discussed and compared to our theoretical results. Furthermore we compute, using time dependent DMRG, the dynamical correlations of a single spin ladder. Our results allow to directly describe the inelastic neutron scattering cross section up to high energies. We focus on the evolution of the spectra with the magnetic field and compare their behavior for different couplings. The characteristic features of the spectra are interpreted using different analytical approaches such as the mapping onto a spin chain, a Luttinger liquid (LL) or onto a t-J model. For values of parameters for which such measurements exist, we compare our results to inelastic neutron scattering experiments on the compound BPCB and find excellent agreement. We make additional predictions for the high energy part of the spectrum that are potentially testable in future experiments.Comment: 35 pages, 26 figure