847 research outputs found
Stroke research priorities for the next decade - A supplement statement on intracranial haemorrhage
Etude de la composition lipidique du raisin, Vitis vinifera L.: Evolution au cours de la maturation et localisation dans la baie
Lipid composition of grapevine berries, Vitis vinifera L.:Changes during maturation and localization in the berryQuantitative determinations in four grapevine varieties, Vitis vinifera L., gave evidence that the level of fatty acids in mature be rries was around 0.045 %, for t he main part unsaturated acids. Linoleic, pa lmit ic, linolenic and oleic acids were the most abundant, followed by stearic and behenic acids . No free fatty acids were found. Phospholipids formed the largest fraction prior to neutral and glycolipids. Glycolipids showed a high level of linolenic acid, while in phospho- and neutral lipids linoleic acid was highest. In the three fractions, polyunsaturated acids made up more th an half of total fatty acids. No differences were found between grape varieties. During grape maturation, changes in fatty acid levels were low, except for linolenic acid, which decreased consistently, this decline was concerned with neutral and glycolipids. Consequently, the potential of herbaceous flavour decreased progressively during berry maturation. Fatty acids were 1.5-3 times lower in pulp than in skin; thus, the skin can contribute to a large enrichment of fatty acids in juice, polyunsaturated derivatives, especially linolenic acid, being highest. In consequence, the presence of a !a rge part of grape herbaceous flavour potential in the skin was confirmed. Fatty acid patterns were s imilar in pulp and in skin, with more than half consisting of polyunsaturated compounds. There were a lso identical patterns for other lipids such as phospholipids, which were t he most abundant, followed by neutral and glycolipids
Clinical, Neuroimaging, and Genetic Markers in Cerebral Amyloid Angiopathy-Related Inflammation: A Systematic Review and Meta-Analysis
Background: There are limited data regarding the prevalence of distinct clinical, neuroimaging and genetic markers among patients diagnosed with cerebral amyloid angiopathy-related inflammation (CAA-ri). We sought to determine the prevalence of clinical, radiological, genetic and cerebrospinal fluid biomarker findings in patients with CAA-ri. Methods: A systematic review and meta-analysis of published studies including patients with CAA-ri was conducted to determine the prevalence of clinical, neuroimaging, genetic and cerebrospinal fluid biomarker findings. Subgroup analyses were performed based on (1) prospective or retrospective study design and (2) CAA-ri diagnosis with or without available biopsy. We pooled the prevalence rates using random-effects models and assessed the heterogeneity using Cochran-Q and I2-statistics. Results: We identified 4 prospective and 17 retrospective cohort studies comprising 378 patients with CAA-ri (mean age, 71.5 years; women, 52%). The pooled prevalence rates were as follows: cognitive decline at presentation 70% ([95% CI, 54%-84%]; I2=82%), focal neurological deficits 55% ([95% CI, 40%-70%]; I2=82%), encephalopathy 54% ([95% CI, 39%-68%]; I2=43%), seizures 37% ([95% CI, 27%-49%]; I2=65%), headache 31% ([95% CI, 22%-42%]; I2=58%), T2/fluid-attenuated inversion recovery-hyperintense white matter lesions 98% ([95% CI, 93%-100%]; I2=44%), lobar cerebral microbleeds 96% ([95% CI, 92%-99%]; I2=25%), gadolinium enhancing lesions 54% ([95% CI, 42%-66%]; I2=62%), cortical superficial siderosis 51% ([95% CI, 34%-68%]; I2=77%) and lobar macrohemorrhage 40% ([95% CI, 11%-73%]; I2=88%). The prevalence rate of the ApoE (Apolipoprotein E) ϵ4/ϵ4 genotype was 34% ([95% CI, 17%-53%]; I2=76%). Subgroup analyses demonstrated no differences in these prevalence rates based on study design and diagnostic strategy. Conclusions: Cognitive decline was the most common clinical feature. Hyperintense T2/fluid-attenuated inversion recovery white matter lesions and lobar cerebral microbleeds were by far the most prevalent neuroimaging findings. Thirty-four percent of patients with CAA-ri have homozygous ApoE ϵ4/ϵ4 genotype and scarce data exist regarding the cerebrospinal fluid biomarkers and its significance in these patients
Photomorphogenic mutants of tomato
Photomorphogenesis of tomato is being studied with the aid of mutants which are either modified in their photore-
ceptor composition or in their signal transduction chain(s)
. Several mutants affecting the phytochrome family of
photoreceptors, some of which appear deficient for specific genes encoding phytochrome apoproteins have been
isolated
. In addition, other mutants, including transgenic lines overexpressing phytochrome A, exhibit exaggerated
photomorphogenesis during de-etiolation
. Anthocyanin biosynthesis and plastid development are being used
as
model systems for the dissection of the complex interactions among photomorphogenic photoreceptors and to
elucidate the nature of their transduction chains
Treatment with granulocyte colony-stimulating factor after allogeneic bone marrow transplantation for acute leukemia increases the risk of graft-versus-host disease and death
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The effects of financialisation and financial development on investment: Evidence from firm-level data in Europe
In this paper we estimate the effects of financialization on physical investment in selected western European countries using panel data based on the balance-sheets of publicly listed non-financial companies (NFCs) supplied by Worldscope for the period 1995-2015. We find robust evidence of an adverse effect of both financial payments
(interests and dividends) and financial incomes on investment in fixed assets by the NFCs. This finding is robust for both the pool of all Western European firms and single country estimations. The negative impacts of financial incomes are non-linear with respect to the companies’ size: financial incomes crowd-out investment in large companies, and have a positive effect on the investment of only small, relatively more credit-constrained companies. Moreover, we find that a higher degree of financial development is associated with a stronger negative effect of financial incomes on companies’ investment. This finding challenges the common wisdom on ‘finance-growth nexus’. Our findings support the ‘financialization thesis’ that the increasing orientation of the non-financial sector towards financial activities is ultimately leading to lower physical investment, hence to stagnant or fragile growth, as well as long term stagnation in productivity
The influence of cycloplegic in objective refraction
The purpose of this study was to compare refractions measured with an autorefractor and retinoscopy in cycloplegic and non-cycloplegic eyes.
The objective refractions were performed in 199 right eyes from 199 healthy young adults with a mean age of 21.6 ±2.66 years. The measurements were performed first without cycloplegia and repeated 30 minutes later with cycloplegia.
Data were analyzed using Fourier decomposition of the power profile.
More negative values of component M and J0 were give by non-cycloplegic autorefraction compared to cycloplegic autorefraction (p<0.001). However more positive values were given by non-cycloplegic autorefraciton regarding to the J45 vector, althought this differences were not statistically significant (p=0.233).
Regarding retinoscopy, more negative values of component M where obtained with non-cycloplegic retinoscopy (p<0.001); for the cylindrical vectors J0 and J45 the retinoscopy without cycloplegic yields more negative values (p= 0.234; p= 0.112, respectively).
Accepting that differences between cycloplegic and non-cycloplegic retinoscopy are only due to accommodative response, present results confirm that when performed by an experienced clinician, retinoscopy is a more reliable method to obtain objective start point for refraction under non-cycloplegic conditions
Interactive Generation of Time-Evolving Snow-Covered Landscaped with Avalanches
We introduce a novel method for interactive generation of visually consistent, snow-covered landscapes and provide control of their dynamic evolution over time. Our main contribution is the real-time phenomenological simulation of avalanches and other user-guided events, such as tracks left by Nordic skiing, which can be applied to interactively sculpt the landscape. The terrain is modeled as a height field with additional layers for stable, compacted, unstable, and powdery snow, which behave in combination as a semi-viscous fluid. We incorporate the impact of several phenomena, including sunlight, temperature, prevailing wind direction, and skiing activities. The snow evolution includes snow-melt and snow-drift, which affect stability of the snow mass and the probability of avalanches. A user can shape landscapes and their evolution either with a variety of interactive brushes, or by prescribing events along a winter season time-line. Our optimized GPU-implementation allows interactive updates of snow type and depth across a large (10×10km) terrain, including real-time avalanches, making this suitable for visual assets in computer games. We evaluate our method through perceptual comparison against exiting methods and real snow-depth data
La macération pelliculaire dans la vinification en blanc - Incidence sur la composante volatile des vins
Skin contact in white wine processing- Effects on the volatile constituents of winesWines were made from three different white vine cultivars, Chenin, Chardonnay, Bourboulenc by standard white wine processing, with and without skin contact, and their volatile constituents were analysed using gas chromatography standard procedures. 61 substances were identified and quantified in quadruplicate. One-way analyses of variance for each component were performed in which skin contact wine was compared to the control wine for each vine cultivar. Skin contact was shown to increase significantly most volatile components except volatile acids. In attempt to classify the wines investigated, principal component analysis was conducted using the amounts of compounds differing significantly in variance analysis
Prevalence, Characteristics and Outcomes of Undetermined Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis
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