Models of National Settlement Systems: 2. How Can One Approach Policy Oriented Modeling of Poorly Understood Systems?

The aim of this note is to highlight some of the difficulties in the dynamical modeling of poorly understood systems, and to call for a strategy that integrates fundamental research on the structure of workings of the urban system with the policy need for methodologies that analyze through time the effects and repercussions of alternative policies

Dynamic Models of the Interaction between Migration and the Differential Growth of Cities

The general area of interest of this paper is the dynamic relationship between regional imbalances, migration, and the differential growth of cities. In particular, the paper considers the feasibility of building dynamic models of the economic and demographic interactions between a set of linked cities, which could be used to explore the effects and repercussions of national settlement policies addressed at the alleviation of imbalances. Inter-regional economic growth models are well known, and, recently several papers have focused on inter-regional demographic models. There has been less research on the dynamics of the interdependent interaction between economic and demographic growth. This paper focuses on this economic-demographic adjustment for a system of linked city regions and considers research results which point to several difficulties in building theoretically well structured dynamic models of differential city growth. Part of the paper considers the inadequacies of current theories of inter-regional population migration and a new approach based on job-search theory is outlined

On the extrapolation to ITER of discharges in present tokamaks

An expression for the extrapolated fusion gain G = Pfusion /5 Pheat (Pfusion being the total fusion power and Pheat the total heating power) of ITER in terms of the confinement improvement factor (H) and the normalised beta (betaN) is derived in this paper. It is shown that an increase in normalised beta can be expected to have a negative or neutral influence on G depending on the chosen confinement scaling law. Figures of merit like H betaN / q95^2 should be used with care, since large values of this quantity do not guarantee high values of G, and might not be attainable with the heating power installed on ITER.Comment: 6 Pages, 3 figures, Submitted to Nuclear Fusion on the 29th of November 200

Lorsque les électrosensibles racontent : des douleurs chroniques aux pratiques d'auto-éviction

Résumé : Cet article propose une analyse du vécu de personnes électrosensibles et de la façon dont ils ont répondu aux douleurs chroniques. L'approche proposée vise à relater les stratégies de réponse à ces formes de morbidité en valorisant les récits des protagonistes ; plus particulièrement, l'accent est mis sur les dimensions cognitives, sensorielles, émotionnelles, relationnelles et existentielles engendrées par une symptomatologie qui ne correspond à aucune explication scientifique causale. Leurs récits mettent ainsi en perspective des trajectoires de vie avec les conditions sociales, médicales et somatiques dans lesquelles est menée leur quête de santé. Mettre l'accent sur les expériences quotidiennes qui fondent la représentation que les électrosensibles ont de leurs troubles permet de comprendre les raisons et les modalités des formes d'auto-éviction qu'ils pratiquent. La réalisation des modalités de l'auto-éviction sont alors interprétées comme l'aboutissement d'une trajectoire de vie, produit de choix intuitifs - et non stratégiques - basés sur des sensibilités singulières. Il en résulte un regard anthropologique invitant à interpréter l'expérience des douleurs chroniques au prisme des rapports sensibles que les individus entretiennent avec leur corps, les autres et l'environnement. Abstract: This paper analyses the lived experience of electrosensitive people and the way they reply to chronic pain. The approach aims to relate the way they reply to this kind of morbidity by highlighting their narratives; especially by emphasising the cognitive, the sensorial, the emotional, the relational and the existential dimensions produced by a symptomatology that is not scientifically explained. Their narratives put into perspective their life trajectories with the social, medical and somatic conditions that lead their health quest. Focusing on the ordinary, that shapes the representations the electrosensitive people have of their troubles, would allow us to understand the reasons and modalities of auto-eviction practices. Auto-eviction achievement is interpreted as a life trajectory fulfilment produced by intuitive choices - nonstrategic - based on singular sensitivities. As a result, it invites an anthropological interpretation of chronic pain experiences built on the sensitive relationships that individuals have with their body, the others and the environment

Intentional and unintentional medication nonadherence in psoriasis: the role of patients’ medication beliefs and habit strength [abstract only]

The accurate diagnosis of psoriasis has remained a challenge, as no disease-specific biomarkers have yet been identified. Currently, the diagnosis of chronic inflammatory diseases relies mainly on the assessment of visible symptoms or the histological features of the biopsy. This approach is heavily reliant on the experience of the clinician and, therefore, may lead to misdiagnosis as there are numerous different chronic inflammatory skin diseases that may present similar clinical features. Hence, the need for diagnostic biomarkers is clear. Although different investigations have reported the discovery of potential psoriasis biomarkers, still no accurate and reliable biomarker is available. Rather than searching for a single valid biomarker, we propose that applying a multicomponent bio-marker-based approach would result in a higher degree of success and translation into clinical practice. An extensive review of published studies to identify the most relevant psoriasis-specific biomarker candidates was conducted. This led us to conclude that the expression levels of specific genes in the skin hold the most promise as discriminatory biomarkers, resulting in the selection of five genes, the expression levels of which have been demonstrated to be exclusive for psoriasis vulgaris. We first conducted a preliminary validation study applying support vector machine-based classification and principle component analysis on the skin-derived expression data of 12 patients with psoriasis vulgaris and 12 healthy controls, previously produced in our departments. We then confirmed that the expression levels of the five genes in psoriatic lesions indeed present a unique pattern. Encouraged by these results, we continued to develop a quantitative polymerase chain reaction panel to allow the accurate measurement of expression levels for the five genes to be used in the studies to follow. Although we have yet to confirm these results in the context of other chronic inflammatory skin diseases, the results of previously published studies regarding these five genes are promising. Therefore, we are in the process of collecting additional skin samples from patients with chronic inflammatory disease (including different papulosquamous disorders and atopic dermatitis) to validate the discriminatory power of our panel. These results may further be translated to viable clinical diagnostic tests in the near future. This work was supported by the ERA Chair for Translational Genomics and Personalized Medicine at the University of Tartu

New complete genome sequences of human rhinoviruses shed light on their phylogeny and genomic features

<p>Abstract</p> <p>Background</p> <p>Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with enteroviruses and both are part of the picornavirus family. Nevertheless they differ significantly at the phenotypic level. The lack of HRV full-length genome sequences and the absence of analysis comparing picornaviruses at the whole genome level limit our knowledge of the genomic features supporting these differences.</p> <p>Results</p> <p>Here we report complete genome sequences of 12 HRV-A and HRV-B serotypes, more than doubling the current number of available HRV sequences. The whole-genome maximum-likelihood phylogenetic analysis suggests that HRV-B and human enteroviruses (HEV) diverged from the last common ancestor after their separation from HRV-A. On the other hand, compared to HEV, HRV-B are more related to HRV-A in the capsid and 3B-C regions. We also identified the presence of a 2C <it>cis</it>-acting replication element (<it>cre</it>) in HRV-B that is not present in HRV-A, and that had been previously characterized only in HEV. In contrast to HEV viruses, HRV-A and HRV-B share also markedly lower GC content along the whole genome length.</p> <p>Conclusion</p> <p>Our findings provide basis to speculate about both the biological similarities and the differences (e.g. tissue tropism, temperature adaptation or acid lability) of these three groups of viruses.</p

In search of dying radio sources in the local universe

Up till now very few dying sources were known, presumably because the dying phase is short at centimeter wavelengths. We therefore have tried to improve the statistics on sources that have ceased to be active, or are intermittently active. The latter sources would partly consist of a fossil radio plasma left over from an earlier phase of activity, plus a recently restarted core and radio jets. Improving the statistics of dying sources will give us a better handle on the evolution of radio sources, in particular the frequency and time scales of radio activity. We have used the WENSS and NVSS surveys, in order to find sources with steep spectral indices, associated with nearby elliptical galaxies. In the cross correlation we presently used only unresolved sources, with flux densities at 1.4 GHz larger than 10 mJy. The eleven candidates thus obtained were observed with the VLA in various configurations, in order to confirm the steepness of the spectra, and to check whether active structures like flat-spectrum cores and jets are present, perhaps at low levels. We estimated the duration of the active and relic phases by modelling the integrated radio spectra using the standard models of spectral evolution. We have found six dying sources and three restarted sources, while the remaining two candidates remain unresolved also with the new VLA data and may be Compact Steep Spectrum sources, with an unusually steep spectrum. The typical age of the active phase, as derived by spectral fits, is in the range 10^7 - 10^8 years. For our sample of dying sources, the age of the relic phase is on average shorter by an order of magnitude than the active phase.Comment: 21 pages, 17 figures, accepted by A&A. For a version with high quality figures, see http://erg.ca.astro.it/preprints/dying2007