Tratado de Arithmetica, (s. d.)

Este item pertence ao acervo digital da Biblioteca Pública Benedito Leite. Tratado de Arithmetica para uso dos collegios, lyceos e estabelecimentos de instrucção secundaria3 é a primeira obra de autoria de João Antonio Coqueiro, publicada em Paris em 1860, editada por Rey & Belhatte e impressa pela tipografia W. Remquet & Cia, com o apoio do governo da então Província do Maranhão. Apenas duas edições da obra foram publicadas: a 1ª edição datada de 1860, em Paris; e a 2ª edição em 1897 no Rio de Janeiro e impressa pela Casa Mont’Alverne (CASTELLANOS, 2012), sendo um dos livros didáticos indicados e adotados nos programas de Ensino de 1870 e de 1878 do Colégio Pedro II no Rio de Janeiro (LORENZ; VECHIA, 2004, p. 62).Esta obra foi escrita por J. A. Coqueiro. Está dividida em 8 "livros" que são: LIVRO PRIMEIRO, Numeração - Operações fundamentais; LIVRO II, Propriedades elementares dos numeros inteiros; LIVRO III, Theoria das fracções ordinarias - Theoria dos numeros decimaes; LIVRO IV, Medidas; LIVRO V, Potencias e Raízes; LIVRO VI, Approximações numericas; LIVRO VII, Razões - Progressões - Logarithmos; LIVRO VII, Applicações

Study of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames test

Phytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.Key words: Piperaceae, Piper tuberculatum, (Z)-piplartine, mutagenic activated, Ames test

Resultados de pesquisas e estudos de casos: anais.

Editores técnicos, Fernando Luis Dultra Cintra, Humberto Rollemberg Fontes

A autonomia de gestão financeiro-orçamentária em uma autarquia educacional

As universidades baianas têm enfrentado dificuldades financeiras nos últimos anos. A Universidade Estadual do Sudoeste da Bahia (UESB), principal Instituição de Ensino Superior do Sudoeste baiano, não foge à regra. O repasse financeiro tem sido cada vez menor e as limitações orçamentárias um grande empecilho para o desenvolvimento das atividades-fim da Instituição, Ensino, Pesquisa e Extensão. Diante disso surgiu a problemática de pesquisa: A UESB é uma universidade autônoma financeiramente? O presente artigo tem como objetivo averiguar se realmente existiu autonomia financeiro-orçamentária na UESB no ano de 2015. A metodologia utilizada teve caráter quantitativo e o instrumento de coleta de dados foram pesquisas exploratórias e explicativas. A pesquisa bibliográfica referendou a fundamentação teórica e a pesquisa documental serviu de base para análise dos quadros de detalhamento das despesas nos anos de 2014 e 2015. Foram utilizados também documentos complementares, como o Plano de Desenvolvimento Institucional. A análise apontou o seguinte resultado: a UESB não tem muita autonomia sobre seu orçamento e, consequentemente, sobre as suas finanças

Co-cultivation of Synechocystis salina and Pseudokirchneriella subcapitata under varying phosphorus concentrations evidences an allelopathic competition scenario

Microalgae and cyanobacteria have received ample attention in the last few decades due to their environmental and biotechnological applications. Co-cultures of these microorganisms may present benefits particularly on wastewater bioremediation and biomass production. However, the understanding on the interactions between photosynthetic microorganisms is still in an early stage of knowledge. In this line, the aim of the present study was the evaluation of the growth dynamics of co-cultures of a cyanobacterium, Synechocystis salina, and a microalga, Pseudokirchneriella subcapitata, under low phosphate-phosphorus concentrations. Kinetic growth parameters were determined through the Monod and modified Gompertz models and evidence of allelochemical production was confirmed through metabolomic analysis of the supernatant obtained from the co-cultures using GC-MS and 1D-NMR. Kinetic growth parameters have shown that P. subcapitata was better adapted to grow under low phosphorus concentrations. Co-cultivation of these microorganisms did not influence P. subcapitata growth; however, S. salina growth was strongly inhibited. The modified Gompertz model has shown that growth inhibition of S. salina in co-cultures may be related to the activity of allelochemicals produced by P. subcapitata. This assumption was corroborated by the assessment of the antimicrobial potential of lactic acid (2-hydroxypropanoic acid), an organic acid identified in the supernatant from the co-cultures with growth inhibitory effects against S. salina

Antibiotic adjuvants from Buxus sempervirens to promote effective treatment of drug-resistant Staphylococcus aureus biofilms

Plants have been long scrutinized in the quest for new antibiotics, but no strong antibiotic molecule was ever found. Evidence exists that most phytochemicals have a regulatory or adjuvant effect on other antibacterial compounds, thus promoting a greater therapeutic effect. The current study assessed twenty-eight plants from different families for their antibacterial activity and as adjuvants in antibiotic therapy against Staphylococcus aureus, including methicillin-resistant S. aureus (MRSA). Eucalyptus globulus, Castanea sativa, Agrimonia eupatoria and Fraxinus excelsior methanolic extracts showed antibacterial activity with minimal inhibitory concentrations (MICs) of 0.125-0.5, 0.5-1.0, 1.0-2.0, and 2.0-4.0 g L (1), respectively. Non-antibacterial plants were assessed in combination with ampicillin, oxacillin, ciprofloxacin, erythromycin and tetracycline by a modified disc diffusion test. Methanolic extracts of Acacia dealbata, Prunus spp. plants, Centaurea nigra, Eupatorium cannabium and Buxus sempervirens showed a potentiating effect mostly of ciprofloxacin, erythromycin and tetracycline. B. sempervirens was selected for its potentiating activity and applied against S. aureus biofilms. B. sempervirens (1 g L-1) was able to cause an 88% reduction of S. aureus within 1 h exposure. Further phytochemical investigation of B. sempervirens allowed to identify betulinic acid as a major component, together with other triterpenoids. Betulinic acid and other common terpernoids - lupeol, betulin, hederagenin, ursolic acid and oleanolic acid, were tested for antibacterial and antibiotic-potentiating activities. Among the tested compounds, oleanolic acid and ursolic acid - were highlighted, showing MIC of 62.5 and 15.6 mg L-1, respectively, against S. aureus. Additionally, oleanolic acid showed synergism when combined with tetracycline and erythromycin and caused biofilm reductions of 70, 81 and 85% when applied at 1/2 MIC, MIC and 2 x MIC, respectively

Looking to nature for a new concept in antimicrobial treatments: Isoflavonoids from Cytisus striatus as antibiotic adjuvants against MRSA

Plant science