Preface "Operational oceanography in the Mediterranean Sea: the second stage of development"

The papers of this special issue overview some of the scientific results of the second phase of development of the Mediterranean Forecasting System (MFS) realised during the EU project "Mediterranean ocean Forecasting System: Toward Environmental Predictions-MFSTEP" that started 1 March 2003 and ended in June 2006. The MFS oceanographic service that is now operational in the Mediterranean Sea was developed, implemented and quality assessed during MFSTEP. MFS is composed of: a) a near real time observing system with satellite and in situ elements; b) a numerical ocean forecasting system at basin scale, assimilating all data available in real time, and a set of limited area forecasting models in different sub-regional and shelf areas; c) biochemical models for algal biomass forecasting; d) a product dissemination system. Moreover, the products of MFS are used to develop downstream services, such as oil spill drift and dispersion, sediment transport in the coastal areas and fish stock assessment that demonstrate the value of the operational service for end-users. MFSTEP contained several phases of development and realised a demonstration exercise, the so-called Targeted Operational Period-TOP that started in September 2004 and ended in March 2005. During TOP all possible observing platforms were active, the numerical models were capable to assimilate the observations and the all models were running in forecast mode, from the basin scale to the shelf areas. The deployed observing and modelling components of MFS are now part of a sustained operational oceanographic service for the Mediterranean Sea, so-called Mediterranean Operational Oceanography Network (MOON, http: //www.moon-oceanforecasting.eu)

Mediterranean ocean Forecasting System: Toward Environmental Predictions-MFSTEP Executive Summary

Objectives: The Project aims at the further development of an operational forecasting system for the Mediterranean Sea based upon three main components: a) a Real Time-RT Observing system; b) a numerical forecasting system at the basin scale and for the sub-regional/shelf areas; c) the forecast products dissemination/exploitation system. The Observing system component consists of: • a SOOP-VOS system with RT data dissemination and test of new sensors that collect multidisciplinary data; • a moored buoy network (M3A) designed to serve the RT validation of the basin scale models and the calibration of the ecosystem models; • a satellite RT data analysis system using several satellites for sea surface elevation, sea surface temperature and sea surface winds; • a high space-time resolution network of autonomous subsurface profiling floats (Array for Real-Time Geostrophic Oceanography-ARGO); • a basin scale glider autonomous vehicle experiment; The sampling strategy is continuously assessed by the Observing System Simulation Experiment (OSSE) activities and a RT data management and delayed mode archiving system has been organized

Understanding Reasons for Cancer Disparities in Italy: A Qualitative Study of Barriers and Needs of Cancer Patients and Healthcare Providers

BackgroundThe second leading cause of death in Italy is cancer. Substantial disparities persist in the level of care and outcomes for cancer patients across various communities, hospitals, and regions in Italy. While substantial progress has been made in medical research and treatment options, these advancements tend to disproportionately benefit the wealthier, better-educated, and more privileged areas and portions of the population. Therefore, the primary aim of the current study is to explore possible reasons for inequalities in access to and utilisation of care from the perspective of cancer patients, who are recipients of these treatments, and healthcare providers, who are responsible for their administration.MethodsAfter being recruited through social media platforms, patients' organisations, and hospital websites, cancer patients (n = 22) and healthcare providers (n = 16) from various Italian regions participated in online focus group discussions on disparities in access to and provision of care. Video and audio recordings of the interviews were analysed using Thematic analysis.ResultsAmong cancer patients, 7 themes were identified, while 6 themes emerged from the healthcare providers highlighting encountered barriers and unmet needs in cancer care. Most of these emerging themes are common to both groups, such as geographical disparities, information deficiencies, and the importance of psycho-oncological support. However, several themes are specific to each group, for instance, cancer patients highlight the financial burden and the poor interactions with healthcare providers, while healthcare providers emphasise the necessity of establishing a stronger specialists' network and integrating clinical practice and research.ConclusionCurrent findings reveal persistent challenges in cancer care, including long waiting lists and regional disparities, highlighting the need for inclusive healthcare strategies. The value of psycho-oncological support is underscored, as well as the potential of the Internet's use for informational needs, emphasising the imperative for improved awareness and communication to overcome disparities in cancer care

Oil spill forecasting in the Mediterranean Sea

In this work sensitivity experiments to the coupled MFS (currents) and MEDSLIK (oil spill) input parameters will be shown and results will be compared with observations. In these experiments the drift angle, the drift factor, the currents depth, the type of oil, horizontal diffusivity and the horizontal and temporal current resolution were changed

Drift simulation of MH370 debris using superensemble techniques

On 7 March 2014 (UTC), Malaysia Airlines flight 370 vanished without a trace. The aircraft is believed to have crashed in the southern Indian Ocean, but despite extensive search operations the location of the wreckage is still unknown. The first tangible evidence of the accident was discovered almost 17 months after the disappearance. On 29 July 2015, a small piece of the right wing of the aircraft was found washed up on the island of Réunion, approximately 4000 km from the assumed crash site. Since then a number of other parts have been found in Mozambique, South Africa and on Rodrigues Island. This paper presents a numerical simulation using high-resolution oceanographic and meteorological data to predict the movement of floating debris from the accident. Multiple model realisations are used with different starting locations and wind drag parameters. The model realisations are combined into a superensemble, adjusting the model weights to best represent the discovered debris. The superensemble is then used to predict the distribution of marine debris at various moments in time. This approach can be easily generalised to other drift simulations where observations are available to constrain unknown input parameters. The distribution at the time of the accident shows that the discovered debris most likely originated from the wide search area between 28 and 35° S. This partially overlaps with the current underwater search area, but extends further towards the north. Results at later times show that the most probable locations to discover washed-up debris are along the African east coast, especially in the area around Madagascar. The debris remaining at sea in 2016 is spread out over a wide area and its distribution changes only slowly

Parallel implementation of the SHYFEM (System of HydrodYnamic Finite Element Modules) model

This paper presents the message passing interface (MPI)-based parallelization of the three-dimensional hydrodynamic model SHYFEM (System of HydrodYnamic Finite Element Modules). The original sequential version of the code was parallelized in order to reduce the execution time of high-resolution configurations using state-of-the-art high-performance computing (HPC) systems. A distributed memory approach was used, based on the MPI. Optimized numerical libraries were used to partition the unstructured grid (with a focus on load balancing) and to solve the sparse linear system of equations in parallel in the case of semi-to-fully implicit time stepping. The parallel implementation of the model was validated by comparing the outputs with those obtained from the sequential version. The performance assessment demonstrates a good level of scalability with a realistic configuration used as benchmark

Addressing disparities in European cancer outcomes: a qualitative study Protocol of the BEACON project

Introduction: Health disparities represent a crucial factor in cancer survival rates, awareness, quality of life, and mental health of people receiving a cancer diagnosis and their families. Income, education, geographic location, and ethnicity are some of the most important underlying reasons for health disparities in cancer across Europe. Costs of healthcare, access to information, psycho-oncological support options, integration of cancer research and innovative care, and multidisciplinary cancer teams are the main target areas when it comes to addressing disparities in the cancer context. As part of the Beacon Project (BEACON), we developed a protocol for a qualitative study to explore and identify any relevant reasons for cancer inequalities and disparities in Europe. Methods: Our four stakeholders namely, cancer patients, healthcare providers, researchers, and policymakers will be recruited online, facilitated by collaborative efforts with cancer organizations from various European countries, including but not limited to Italy, Croatia, Estonia, and Slovenia. Qualitative online focus group discussions for each stakeholder will be conducted and transcribed. Subsequently, thematic analysis will be used to identify reasons and aspects that may contribute to the existing disparities in cancer outcomes at various levels of engagement and from different stakeholders’ perspectives. Results from focus groups will inform a subsequent Delphi study and a SWOT analysis methodology. Discussion: Although advances in medical research, cancer screening and treatment options are constantly progressing, disparities in access to and awareness of healthcare in cancer patients are even more noticeable. Thus, mapping the capacity and capability of cancer centres in the European Union, creating decision support tools that will assist the four stakeholders’ information needs and improving the quality of European cancer centres will be the main objectives of the BEACON project. The current protocol will outline the methodological and practical procedures to conduct online focus group discussions with different stakeholders

Real-time optical manipulation of cardiac conduction in intact hearts

Optogenetics has provided new insights in cardiovascular research, leading to new methods for cardiac pacing, resynchronization therapy and cardioversion. Although these interventions have clearly demonstrated the feasibility of cardiac manipulation, current optical stimulation strategies do not take into account cardiac wave dynamics in real time. Here, we developed an all‐optical platform complemented by integrated, newly developed software to monitor and control electrical activity in intact mouse hearts. The system combined a wide‐field mesoscope with a digital projector for optogenetic activation. Cardiac functionality could be manipulated either in free‐run mode with submillisecond temporal resolution or in a closed‐loop fashion: a tailored hardware and software platform allowed real‐time intervention capable of reacting within 2 ms. The methodology was applied to restore normal electrical activity after atrioventricular block, by triggering the ventricle in response to optically mapped atrial activity with appropriate timing. Real‐time intraventricular manipulation of the propagating electrical wavefront was also demonstrated, opening the prospect for real‐time resynchronization therapy and cardiac defibrillation. Furthermore, the closed‐loop approach was applied to simulate a re‐entrant circuit across the ventricle demonstrating the capability of our system to manipulate heart conduction with high versatility even in arrhythmogenic conditions. The development of this innovative optical methodology provides the first proof‐of‐concept that a real‐time optically based stimulation can control cardiac rhythm in normal and abnormal conditions, promising a new approach for the investigation of the (patho)physiology of the heart