The papers of this special issue overview some of the scientific results of the second phase of development of the Mediterranean Forecasting System (MFS) realised during the EU project "Mediterranean ocean Forecasting System: Toward Environmental Predictions-MFSTEP" that started 1 March 2003 and ended in June 2006. The MFS oceanographic service that is now operational in the Mediterranean Sea was developed, implemented and quality assessed during MFSTEP. MFS is composed of: a) a near real time observing system with satellite and in situ elements; b) a numerical ocean forecasting system at basin scale, assimilating all data available in real time, and a set of limited area forecasting models in different sub-regional and shelf areas; c) biochemical models for algal biomass forecasting; d) a product dissemination system. Moreover, the products of MFS are used to develop downstream services, such as oil spill drift and dispersion, sediment transport in the coastal areas and fish stock assessment that demonstrate the value of the operational service for end-users. MFSTEP contained several phases of development and realised a demonstration exercise, the so-called Targeted Operational Period-TOP that started in September 2004 and ended in March 2005. During TOP all possible observing platforms were active, the numerical models were capable to assimilate the observations and the all models were running in forecast mode, from the basin scale to the shelf areas. The deployed observing and modelling components of MFS are now part of a sustained operational oceanographic service for the Mediterranean Sea, so-called Mediterranean Operational Oceanography Network (MOON, http: //www.moon-oceanforecasting.eu)
