Compact, Miniature MMIC Receiver Modules for an MMIC Array Spectrograph

A single-pixel prototype of a W-band detector module with a digital back-end was developed to serve as a building block for large focal-plane arrays of monolithic millimeter-wave integrated circuit (MMIC) detectors. The module uses low-noise amplifiers, diode-based mixers, and a WR10 waveguide input with a coaxial local oscillator. State-of-the-art InP HEMT (high electron mobility transistor) MMIC amplifiers at the front end provide approximately 40 dB of gain. The measured noise temperature of the module, at an ambient temperature of 300 K, was found to be as low as 450 K at 95 GHz. The modules will be used to develop multiple instruments for astrophysics radio telescopes, both on the ground and in space. The prototype is being used by Stanford University to characterize noise performance at cryogenic temperatures. The goal is to achieve a 30-50 K noise temperature around 90 GHz when cooled to a 20 K ambient temperature. Further developments include characterization of the IF in-phase (I) and quadrature (Q) signals as a function of frequency to check amplitude and phase; replacing the InP low-noise amplifiers with state-of-the-art 35-nm-gate-length NGC low-noise amplifiers; interfacing the front-end module with a digital back-end spectrometer; and developing a scheme for local oscillator and IF distribution in a future array. While this MMIC is being developed for use in radio astronomy, it has the potential for use in other industries. Applications include automotive radar (both transmitters and receivers), communication links, radar systems for collision avoidance, production monitors, ground-penetrating sensors, and wireless personal networks

Fc Glycan-Mediated Regulation of Placental Antibody Transfer.

Despite the worldwide success of vaccination, newborns remain vulnerable to infections. While neonatal vaccination has been hampered by maternal antibody-mediated dampening of immune responses, enhanced regulatory and tolerogenic mechanisms, and immune system immaturity, maternal pre-natal immunization aims to boost neonatal immunity via antibody transfer to the fetus. However, emerging data suggest that antibodies are not transferred equally across the placenta. To understand this, we used systems serology to define Fc features associated with antibody transfer. The Fc-profile of neonatal and maternal antibodies differed, skewed toward natural killer (NK) cell-activating antibodies. This selective transfer was linked to digalactosylated Fc-glycans that selectively bind FcRn and FCGR3A, resulting in transfer of antibodies able to efficiently leverage innate immune cells present at birth. Given emerging data that vaccination may direct antibody glycosylation, our study provides insights for the development of next-generation maternal vaccines designed to elicit antibodies that will most effectively aid neonates.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

PICO - the probe of inflation and cosmic origins

International audienceThe Probe of Inflation and Cosmic Origins (PICO) is a NASA-funded study of a Probe-class mission concept. The toplevel science objectives are to probe the physics of the Big Bang by measuring or constraining the energy scale of inflation, probe fundamental physics by measuring the number of light particles in the Universe and the sum of neutrino masses, to measure the reionization history of the Universe, and to understand the mechanisms driving the cosmic star formation history, and the physics of the galactic magnetic field. PICO would have multiple frequency bands between 21 and 799 GHz, and would survey the entire sky, producing maps of the polarization of the cosmic microwave background radiation, of galactic dust, of synchrotron radiation, and of various populations of point sources. Several instrument configurations, optical systems, cooling architectures, and detector and readout technologies have been and continue to be considered in the development of the mission concept. We will present a snapshot of the baseline mission concept currently under development

PICO: Probe of Inflation and Cosmic Origins

The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost

PICO: Probe of Inflation and Cosmic Origins

The Probe of Inflation and Cosmic Origins (PICO) is an imaging polarimeter that will scan the sky for 5 years in 21 frequency bands spread between 21 and 799 GHz. It will produce full-sky surveys of intensity and polarization with a final combined-map noise level of 0.87 $\mu$K arcmin for the required specifications, equivalent to 3300 Planck missions, and with our current best-estimate would have a noise level of 0.61 $\mu$K arcmin (6400 Planck missions). PICO will either determine the energy scale of inflation by detecting the tensor to scalar ratio at a level $r=5\times 10^{-4}~(5\sigma)$, or will rule out with more than $5\sigma$ all inflation models for which the characteristic scale in the potential is the Planck scale. With LSST's data it could rule out all models of slow-roll inflation. PICO will detect the sum of neutrino masses at $>4\sigma$, constrain the effective number of light particle species with $\Delta N_{\rm eff}<0.06~(2\sigma)$, and elucidate processes affecting the evolution of cosmic structures by measuring the optical depth to reionization with errors limited by cosmic variance and by constraining the evolution of the amplitude of linear fluctuations $\sigma_{8}(z)$ with sub-percent accuracy. Cross-correlating PICO's map of the thermal Sunyaev-Zeldovich effect with LSST's gold sample of galaxies will precisely trace the evolution of thermal pressure with $z$. PICO's maps of the Milky Way will be used to determine the make up of galactic dust and the role of magnetic fields in star formation efficiency. With 21 full sky legacy maps in intensity and polarization, which cannot be obtained in any other way, the mission will enrich many areas of astrophysics. PICO is the only single-platform instrument with the combination of sensitivity, angular resolution, frequency bands, and control of systematic effects that can deliver this compelling, timely, and broad science

PICO: Probe of Inflation and Cosmic Origins

The Probe of Inflation and Cosmic Origins (PICO) is an imaging polarimeter that will scan the sky for 5 years in 21 frequency bands spread between 21 and 799 GHz. It will produce full-sky surveys of intensity and polarization with a final combined-map noise level of 0.87 $\mu$K arcmin for the required specifications, equivalent to 3300 Planck missions, and with our current best-estimate would have a noise level of 0.61 $\mu$K arcmin (6400 Planck missions). PICO will either determine the energy scale of inflation by detecting the tensor to scalar ratio at a level $r=5\times 10^{-4}~(5\sigma)$, or will rule out with more than $5\sigma$ all inflation models for which the characteristic scale in the potential is the Planck scale. With LSST's data it could rule out all models of slow-roll inflation. PICO will detect the sum of neutrino masses at $>4\sigma$, constrain the effective number of light particle species with $\Delta N_{\rm eff}<0.06~(2\sigma)$, and elucidate processes affecting the evolution of cosmic structures by measuring the optical depth to reionization with errors limited by cosmic variance and by constraining the evolution of the amplitude of linear fluctuations $\sigma_{8}(z)$ with sub-percent accuracy. Cross-correlating PICO's map of the thermal Sunyaev-Zeldovich effect with LSST's gold sample of galaxies will precisely trace the evolution of thermal pressure with $z$. PICO's maps of the Milky Way will be used to determine the make up of galactic dust and the role of magnetic fields in star formation efficiency. With 21 full sky legacy maps in intensity and polarization, which cannot be obtained in any other way, the mission will enrich many areas of astrophysics. PICO is the only single-platform instrument with the combination of sensitivity, angular resolution, frequency bands, and control of systematic effects that can deliver this compelling, timely, and broad science