502 research outputs found
Physical Examination Tests for Screening and Diagnosis of Cervicogenic Headache: A Systematic Review
It has been suggested that differential diagnosis of headaches should consist of a robust subjective ex-amination and a detailed physical examination of the cervical spine. Cervicogenic headache (CGH) is a form of headache that involves referred pain from the neck. To our knowledge, no studies have sum-marized the reliability and diagnostic accuracy of physical examination tests for CGH. The aim of this study was to summarize the reliability and diagnostic accuracy of physical examination tests used to diagnose CGH. A systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines was performed in four electronic databases (MEDLINE, Web of Science, Embase and Scopus). Full text reports concerning physical tests for the diagnosis of CGH which reported the clinometric properties for assessment of CGH, were included and screened for methodological quality. Quality Appraisal for Reliability Studies (QAREL) and Quality Assessment of Studies of Diagnostic Accuracy (QUADAS-2) scores were completed to assess article quality. Eight articles were retrieved for quality assessment and data extraction. Studies investigating diagnostic reliability of physical exami-nation tests for CGH scored poorer on methodological quality (higher risk of bias) than those of diag-nostic accuracy. There is sufficient evidence showing high levels of reliability and diagnostic accuracy of the selected physical examination tests for the diagnosis of CGH. The cervical flexion-rotation test (CFRT) exhibited both the highest reliability and the strongest diagnostic accuracy for the diagnosis of CGH
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Internal fluid flow management analysis for Clinch River Breeder Reactor Plant sodium pumps
The Clinch River Breeder Reactor Plant (CRBRP) sodium pumps are currently being designed and the prototype unit is being fabricated. In the design of these large-scale pumps for elevated temperature Liquid Metal Fast Breeder Reactor (LMFBR) service, one major design consideration is the response of the critical parts to severe thermal transients. A detailed internal fluid flow distribution analysis has been performed using a computer code HAFMAT, which solves a network of fluid flow paths. The results of the analytical approach are then compared to the test data obtained on a half-scale pump model which was tested in water. The details are presented of pump internal hydraulic analysis, and test and evaluation of the half-scale model test results
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85,000-GPM, single-stage, single-suction LMFBR intermediate centrifugal pump
The mechanical and hydraulic design features of the 85,000-gpm, single-stage, single-suction pump test article, which is designed to circulate liquid-sodium coolant in the intermediate heat-transport system of a Large-Scale Liquid Metal Fast Breeder Reactor (LS-LMFBR), are described. The design and analytical considerations used to satisfy the pump performance and operability requirements are presented. The validation of pump hydraulic performance using a hydraulic scale-model pump is discussed, as is the featute test for the mechanical-shaft seal system
Perspectives on tracking data reuse across biodata resources.
Data reuse is a common and vital practice in molecular biology and enables the knowledge gathered over recent decades to drive discovery and innovation in the life sciences. Much of this knowledge has been collated into molecular biology databases, such as UniProtKB, and these resources derive enormous value from sharing data among themselves. However, quantifying and documenting this kind of data reuse remains a challenge.
The article reports on a one-day virtual workshop hosted by the UniProt Consortium in March 2023, attended by representatives from biodata resources, experts in data management, and NIH program managers. Workshop discussions focused on strategies for tracking data reuse, best practices for reusing data, and the challenges associated with data reuse and tracking. Surveys and discussions showed that data reuse is widespread, but critical information for reproducibility is sometimes lacking. Challenges include costs of tracking data reuse, tensions between tracking data and open sharing, restrictive licenses, and difficulties in tracking commercial data use. Recommendations that emerged from the discussion include: development of standardized formats for documenting data reuse, education about the obstacles posed by restrictive licenses, and continued recognition by funding agencies that data management is a critical activity that requires dedicated resources.
Summaries of survey results are available at: https://docs.google.com/forms/d/1j-VU2ifEKb9C-sW6l3ATB79dgHdRk5v_lESv2hawnso/viewanalytics (survey of data providers) and https://docs.google.com/forms/d/18WbJFutUd7qiZoEzbOytFYXSfWFT61hVce0vjvIwIjk/viewanalytics (survey of users)
Review article: MHD wave propagation near coronal null points of magnetic fields
We present a comprehensive review of MHD wave behaviour in the neighbourhood
of coronal null points: locations where the magnetic field, and hence the local
Alfven speed, is zero. The behaviour of all three MHD wave modes, i.e. the
Alfven wave and the fast and slow magnetoacoustic waves, has been investigated
in the neighbourhood of 2D, 2.5D and (to a certain extent) 3D magnetic null
points, for a variety of assumptions, configurations and geometries. In
general, it is found that the fast magnetoacoustic wave behaviour is dictated
by the Alfven-speed profile. In a plasma, the fast wave is focused
towards the null point by a refraction effect and all the wave energy, and thus
current density, accumulates close to the null point. Thus, null points will be
locations for preferential heating by fast waves. Independently, the Alfven
wave is found to propagate along magnetic fieldlines and is confined to the
fieldlines it is generated on. As the wave approaches the null point, it
spreads out due to the diverging fieldlines. Eventually, the Alfven wave
accumulates along the separatrices (in 2D) or along the spine or fan-plane (in
3D). Hence, Alfven wave energy will be preferentially dissipated at these
locations. It is clear that the magnetic field plays a fundamental role in the
propagation and properties of MHD waves in the neighbourhood of coronal null
points. This topic is a fundamental plasma process and results so far have also
lead to critical insights into reconnection, mode-coupling, quasi-periodic
pulsations and phase-mixing.Comment: 34 pages, 5 figures, invited review in Space Science Reviews => Note
this is a 2011 paper, not a 2010 pape
Strings on conifolds from strong coupling dynamics, part I
A method to solve various aspects of the strong coupling expansion of the
superconformal field theory duals of AdS_5 x X geometries from first principles
is proposed. The main idea is that at strong coupling the configurations that
dominate the low energy dynamics of the field theory compactified on a three
sphere are given by certain non-trivial semi-classical configurations in the
moduli space of vacua.
We show that this approach is self-consistent and permits one to express most
of the dynamics in terms of an effective N=4 SYM dynamics. This has the
advantage that some degrees of freedom that move the configurations away from
moduli space can be treated perturbatively, unifying the essential low energy
dynamics of all of these theories. We show that with this formalism one can
compute the energies of strings in the BMN limit in the Klebanov-Witten theory
from field theory considerations, matching the functional form of results found
using AdS geometry. This paper also presents various other technical results
for the semiclassical treatment of superconformal field theories.Comment: 52 pages, JHEP3 styl
Maximally incompressible neutron star matter
Relativistic kinetic theory, based on the Grad method of moments as developed
by Israel and Stewart, is used to model viscous and thermal dissipation in
neutron star matter and determine an upper limit on the maximum mass of neutron
stars. In the context of kinetic theory, the equation of state must satisfy a
set of constraints in order for the equilibrium states of the fluid to be
thermodynamically stable and for perturbations from equilibrium to propagate
causally via hyperbolic equations. Application of these constraints to neutron
star matter restricts the stiffness of the most incompressible equation of
state compatible with causality to be softer than the maximally incompressible
equation of state that results from requiring the adiabatic sound speed to not
exceed the speed of light. Using three equations of state based on experimental
nucleon-nucleon scattering data and properties of light nuclei up to twice
normal nuclear energy density, and the kinetic theory maximally incompressible
equation of state at higher density, an upper limit on the maximum mass of
neutron stars averaging 2.64 solar masses is derived.Comment: 8 pages, 2 figure
Research of working area development parameters in conditions of deep steep deposit finalizing
Отримано формули розрахунку об’єму запасів корисних копалин в приконтурній та глибинній зоні. Встановлено характер впливу параметрів доробки глибоких крутоспадних родовищ відкритим способом на доцільне положення поточних та проектних контурів кар’єру. Встановлено, що найменший середній коефіцієнт розкриву досягається при мінімальному значенні суми обсягів корисної копалини приконтурної зони лежачого і висячого боків покладу в проектному положенні. Найменший поточний коефіцієнт розкриву досягається при мінімальному значенні суми обсягів корисної копалини приконтурної зони лежачого і висячого боків покладу, а також робочого борту кар'єру в поточному положенні
Anthropogenic alteration of nutrient supply increases the global freshwater carbon sink
Lakes have a disproportionate effect on the global carbon (C) cycle relative to their area, mediating C transfer from land to atmosphere, and burying organic-C in their sediments. The magnitude and temporal variability of C burial is, however, poorly constrained, and the degree to which humans have influenced lake C cycling through landscape alteration has not been systematically assessed. Here, we report global and biome specific trajectories of lake C sequestration based on 516 lakes and show that some lake C burial rates (i.e., those in tropical forest and grassland biomes) have quadrupled over the last 100 years. Global lake C-sequestration (~0.12 Pg year-1) has increased by ~72 Tg year-1 since 1900, offsetting 20% of annual CO2 freshwater emissions rising to ~30% if reservoirs are included and contributing to the residual continental C sink. Nutrient availability explains ~70% of the observed increase, while rising temperatures have a minimal effect
Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system.
Encounters with neurotropic viruses result in varied outcomes ranging from encephalitis, paralytic poliomyelitis or other serious consequences to relatively benign infection. One of the principal factors that control the outcome of infection is the localized tissue response and subsequent immune response directed against the invading toxic agent. It is the role of the immune system to contain and control the spread of virus infection in the central nervous system (CNS), and paradoxically, this response may also be pathologic. Chemokines are potent proinflammatory molecules whose expression within virally infected tissues is often associated with protection and/or pathology which correlates with migration and accumulation of immune cells. Indeed, studies with a neurotropic murine coronavirus, mouse hepatitis virus (MHV), have provided important insight into the functional roles of chemokines and chemokine receptors in participating in various aspects of host defense as well as disease development within the CNS. This chapter will highlight recent discoveries that have provided insight into the diverse biologic roles of chemokines and their receptors in coordinating immune responses following viral infection of the CNS
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