2,095 research outputs found
Why We Explore: The Value of Space Exploration for Future Generations
The National Aeronautics and Space Administration (NASA) and its industry partners are making measurable progress toward delivering new human space transportation capabilities to serve as the catalyst for a new era of discovery, as directed by the U.S. Vision for Space Exploration. In the interest of ensuring prolonged support, the Agency encourages space advocates of all stripes to accurately portray both the tangible and intangible benefits of space exploration, especially its value for future generations. This may be done not only by emphasizing the nation's return on its aerospace investment, but also by highlighting enabling security features and by promoting the scientific and technological benefits that accrue from the human exploration of space. As America embarks on a new era of leadership and international partnership on the next frontier, we are poised to master space by living off-planet on the Moon to prepare astronauts for longer journeys to Mars. These and other relevant facts should be clearly in the view of influential decision-makers and the American taxpayers, and we must increasingly involve those on whom the long-term sustainability of space exploration ultimately depends: America's youth. This paper will examine three areas of concrete benefits for future generations: fundamental security, economic enterprise, and high-technology advancements spurred by the innovation that scientific discovery demands
Effects of Bulk and Surface Conductivity on the Performance of CdZnTe Pixel Detectors
We studied the effects of bulk and surface conductivity on the performance of
high-resistivity CdZnTe (CZT) pixel detectors with Pt contacts. We emphasize
the difference in mechanisms of the bulk and surface conductivity as indicated
by their different temperature behaviors. In addition, the existence of a thin
(10-100 A) oxide layer on the surface of CZT, formed during the fabrication
process, affects both bulk and surface leakage currents. We demonstrate that
the measured I-V dependencies of bulk current can be explained by considering
the CZT detector as a metal-semiconductor-metal system with two back-to-back
Schottky-barrier contacts. The high surface leakage current is apparently due
to the presence of a low-resistivity surface layer that has characteristics
which differ considerably from those of the bulk material. This surface layer
has a profound effect on the charge collection efficiency in detectors with
multi-contact geometry; some fraction of the electric field lines originated on
the cathode intersects the surface areas between the pixel contacts where the
charge produced by an ionizing particle gets trapped. To overcome this effect
we place a grid of thin electrodes between the pixel contacts; when the grid is
negatively biased, the strong electric field in the gaps between the pixels
forces the electrons landing on the surface to move toward the contacts,
preventing the charge loss. We have investigated these effects by using CZT
pixel detectors indium bump bonded to a custom-built VLSI readout chip
Implantation of a Bi-Ventricular Pacing System in the Setting of Dextrocardia with Situs Inversus Totalis
Dextrocardia with situs inversus totalis is a rare disorder but is frequently associated with anomalous venous return. Pacemaker/Internal Cardioverter Defibrillator implantation in this population can be difficult given the difficult venous anatomy. This case illustrates how beforehand knowledge of the venous anatomy by cardiac MRI can facilitate device implantation
The association of statin use after cancer diagnosis with survival in pancreatic cancer patients: a SEER-medicare analysis.
BackgroundPancreatic cancer has poor prognosis and existing interventions provide a modest benefit. Statin has anti-cancer properties that might enhance survival in pancreatic cancer patients. We sought to determine whether statin treatment after cancer diagnosis is associated with longer survival in those with pancreatic ductal adenocarcinoma (PDAC).MethodsWe analyzed data on 7813 elderly patients with PDAC using the linked Surveillance, Epidemiology, and End Results (SEER) - Medicare claims files. Information on the type, intensity and duration of statin use after cancer diagnosis was extracted from Medicare Part D. We treated statin as a time-dependent variable in a Cox regression model to determine the association with overall survival adjusting for follow-up, age, sex, race, neighborhood income, stage, grade, tumor size, pancreatectomy, chemotherapy, radiation, obesity, dyslipidemia, diabetes, chronic pancreatitis and chronic obstructive pulmonary disease (COPD).ResultsOverall, statin use after cancer diagnosis was not significantly associated with survival when all PDAC patients were considered (HR = 0.94, 95%CI 0.89, 1.01). However, statin use after cancer diagnosis was associated with a 21% reduced hazard of death (Hazard ratio = 0.79, 95% confidence interval (CI) 0.67, 0.93) in those with grade I or II PDAC and to a similar extent in those who had undergone a pancreatectomy, in those with chronic pancreatitis and in those who had not been treated with statin prior to cancer diagnosis.ConclusionsWe found that statin treatment after cancer diagnosis is associated with enhanced survival in patients with low-grade, resectable PDAC
Clustering of solutions in the random satisfiability problem
Using elementary rigorous methods we prove the existence of a clustered phase
in the random -SAT problem, for . In this phase the solutions are
grouped into clusters which are far away from each other. The results are in
agreement with previous predictions of the cavity method and give a rigorous
confirmation to one of its main building blocks. It can be generalized to other
systems of both physical and computational interest.Comment: 4 pages, 1 figur
Rhinal cortex asymmetries in patients with mesial temporal sclerosis
SummaryPurposeThe rhinal cortex, comprising the entorhinal (ErC) and perirhinal (PrC) cortices, is one component of the limbic system that may be affected in patients with epilepsy and other temporal lobe pathologies. This study extended quantitative examination of the limbic system through development and validation of volumetric protocols to measure the ErC and PrC.MethodsVolumes were calculated from MRI studies using ANALYZE 7.5 and based on detailed anatomical definitions developed for the study. Subjects were 61 temporal lobe epilepsy patients with mesial temporal sclerosis (MTS: 33 left, 28 right) and 20 neurologically normal controls. Inter-rater reliabilities for the ErC and PrC volume protocols were found to be high (range 0.86–0.92).ResultsIpsilateral hippocampal volume was reduced in patients with MTS, while contralateral volume did not differ significantly from controls. In the patients, rhinal cortex volumes were reduced as a function of laterality of disease. The pattern of correlations between ErC and PrC differed between disease groups. Hippocampal and rhinal cortex volumes were not significantly correlated. A significant four-way interaction was found between side of MTS, hemisphere, structure and handedness.ConclusionsThis quantitative study demonstrates reliable in vivo evidence of morphometric changes in ErC and PrC in a substantial number of patients with unilateral MTS. The relationship observed between handedness, structure and disease status may suggest a role for cerebral dominance in modulating the expression of MTS
Truncus arteriosus with aortic arch interruption: cardiovascular magnetic resonance findings in the unrepaired adult
Truncus arteriosus (TA) is a rare congenital condition defined as a single arterial vessel arising from the heart that gives origin to the systemic, pulmonary and coronary circulations. We discuss the unique case of a 28 year-old female patient with unrepaired TA and interruption of the aortic arch who underwent cardiovascular magnetic resonance (CMR)
Biological and functional evaluation of a novel pyrolytic carbon implant for the treatment of focal osteochondral defects in the medial femoral condyle: assessment in a canine model
Assessment of left and right ventricular volumes and function with treadmill exercise stress cardiovascular magnetic resonance
The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
Sphingolipids are essential components of cellular membranes and defects in their synthesis or degradation cause severe human diseases. The efficient degradation of sphingolipids in the lysosome requires lipid-binding saposin proteins and hydrolytic enzymes. The glycosphingolipid galactocerebroside is the primary lipid component of the myelin sheath and is degraded by the hydrolase β-galactocerebrosidase (GALC). This enzyme requires the saposin SapA for lipid processing and defects in either of these proteins causes a severe neurodegenerative disorder, Krabbe disease. Here we present the structure of a glycosphingolipid-processing complex, revealing how SapA and GALC form a heterotetramer with an open channel connecting the enzyme active site to the SapA hydrophobic cavity. This structure defines how a soluble hydrolase can cleave the polar glycosyl headgroups of these essential lipids from their hydrophobic ceramide tails. Furthermore, the molecular details of this interaction provide an illustration for how specificity of saposin binding to hydrolases is encoded
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