Vaginosis citolítica: un diagnóstico diferencial poco frecuente de vulvovaginitis micótica a repetición

Indexación: ScieloResumen: Los síntomas compatibles con vaginitis y vaginosis, son la causa más frecuente de consulta al ginecólogo. La descarga vaginal abundante y el prurito, constituyen la primera sospecha de estas patologías. Sin embargo, debemos tener presente que el aumento significativo de lactobacilos, conocido como lactobacilosis, puede expresarse también con los mismos síntomas y signos de una vulvovaginitis micótica. Si esta condición se mantiene en el tiempo, puede provocar un grado de acidez anormal en la vagina, y puede llevar a una lisis de las células epiteliales que se conoce como vaginosis citolítica. Este diagnóstico, aunque es poco frecuente, debemos sospecharlo especialmente, en aquellas mujeres que relatan tener múltiples consultas por candidiasis vaginal, con escasa o nula respuesta frente a la terapia antimicótica.Summary: The symptoms consistent with vaginitis and vaginosis are the most common cause of the visit to the gynecologist. Heavy vaginal discharge and pruritus are the first suspicion of this pathology. However, the significant increase in lactobacilli, known as lactobacilosis can be expressed also with the same symptoms and signs of a fungal vulvovaginitis. If this condition is maintained overtime, can cause abnormal acidity in the vagina, and may lead to epithelial cell lysis, which is known as cytolytic vaginosis. This diagnosis, although rare, should be suspected especially in women who reported having multiple consultations for vaginal candidiasis, with little or no response to antifungal therapy.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75262010000300009&nrm=is

V346 Nor: the post-outburst life of a peculiar young eruptive star

FU Orionis-type objects (FUors) are young low-mass stars undergoing powerful accretion outbursts. The increased accretion is often accompanied by collimated jets and energetic, large-scale molecular outflows. The extra heating during the outburst may also induce detectable geometrical, chemical, and mineralogical changes in the circumstellar material, affecting possible planet formation around these objects. V346 Nor is a southern FUor with peculiar spectral characteristics. Decades after the beginning of its outburst, it unexpectedly underwent a fading event around 2010 due to a decrease in the mass accretion rate onto the star by at least two orders of magnitude. Here we present optical and near-infrared photometry and spectroscopy obtained after the minimum. Our light curves show a gradual re-brightening of V346 Nor, with its K s-band brightness only 1.5 mag below the outburst brightness level. Our Very Large Telescope (VLT)/XSHOOTER spectroscopic observations display several strong forbidden emission lines toward the source from various metals and molecular hydrogen, suggesting the launch of a new jet. Our N-band spectrum obtained with VLT/VISIR outlines a deeper silicate absorption feature than before, indicating that the geometry of the circumstellar medium has changed in the post-outburst period compared to peak brightness.Peer reviewedFinal Published versio

Tumores adenomatoides uterinos: estudio anatomo-patológico e inmunohistoquímico de 32 casos

Indexación: ScieloAntecedentes: Los tumores adenomatoides (TA) son poco frecuentes. Se encuentran principalmente en el aparato reproductor femenino y especialmente en el útero. No existen reportes a nivel nacional sobre estos. Objetivos: Describir las características histológicas e inmunohistoquímicas de los TA uterinos. Método: Estudio descriptivo de 32 muestras ingresadas al Servicio de Anatomía Patológica de Clínica Las Condes. Las muestras estudiadas fueron recopiladas entre noviembre de 1999 y noviembre de 2008. Resultados: El diagnóstico de TA fue realizado en 21 histerectomías y 11 miomectomías. En 14 casos se diagnosticaron como lesiones nodulares únicas (43,8%) y en 18 junto a leiomiomas (56,2%). El tamaño promedio de las lesiones únicas fue 2,6 cm, significativamente mayor que aquellas asociadas a leiomiomas. El patrón histológico predominante más frecuente correspondió al tipo angiomatoide (81,3%), seguido por los patrones adenoide (9,4%), sólido (6,3%) y mixto (3%), no se encontraron TA quísticos. El estudio inmunohistoquími-co fue positivo en el 100% de los casos para citoqueratina AE1/AE3, calrretinina, vimentina y D2-40. Fue negativo para CD31 y CEA. Sólo un 6,3% (2 casos) fue positivo para citoqueratina 5/6. Conclusiones: Los TA corresponden a tumores benignos de origen mesotelial. Generalmente su diagnóstico es un hallazgo. Al presentarse en el útero, se confunden generalmente con leiomiomas o se presentan en conjunto con estos. En base a lo anterior el tratamiento de estas lesiones debe ser conservador, bastando con la resección del tumor.Background: The adenomatoid tumors (AT) are rare. They are found mainly in the female reproductive system and especially in the uterus. There is not national reporting on these. Objective: To describe the his-tological and immunohistochemical features of uterine AT. Method: Descriptive study of 32 patients admitíed to the Pathology Department of Clinica Las Condes. The cases studied were collected between November 1999 and November 2008. Results: The diagnosis of AT was performed in 21 hysterectomies and 11 myomectomies. In 14 patients were diagnosed as nodular single lesions (43.8%) and in 18 cases associated with leiomyomas (56.2%), the average size of single lesions was 2.6 cm, significantly greaterthan those associated with leiomyomas. The predominant histologic type most often correspond to angiomatoid (81.3%), followed by adenoid patterns (9.4%), solid (6.3%) and mixed (3%), the cystic pattern was not observed. The immunohistochemical study of ST was positive in 100% for cytokeratin AE1/AE3, calrretinin, vimentin and D2-40. It was negative for CD31 and CEA. Only 6.3% (2 cases) were positive for cytokeratin 5/6. Conclusio-ns: The AT is a benign tumor of mesothelial origin. Usually the diagnosis is a finding. In the uterus they are generally mistaken with leiomyomas or it is in associated with them. Based on the foregoing the treatment of AT should be conservative, only with resection.http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75262009000600009&nrm=is

MWL observations of VHE blazars in 2006

In 2006 the MAGIC telescope observed the well known very high energy (VHE, > 80 GeV) blazars Mrk 421 and Mrk 501 in the course of multi-wavelength campaigns, comprising measurements in the optical, X-ray and VHE regime. MAGIC performed additional snapshot observations on Mrk 421 around the MWL campaigns and detected the source each night with high significance, establishing once more flux variability on nightly scales for this object. For certain nights, the integral flux exceeded the one of Crab significantly, whereas the truly simultaneous observations have been conducted in a rather low flux state. The MAGIC observations contemporaneous to XMM-Newton revealed clear intra-night variability. No significant correlation between the spectral index and the flux could be found for the nine days of observations. The VHE observations of Mrk 501 have been conducted during one of the lowest flux states ever measured by MAGIC for this object. The VHE and optical light curves do not show significant variability, whereas the flux in X-rays increased by about 50 %. In this contribution, the results of the MAGIC observations will be presented in detail.Comment: Contribution to the 31st ICRC, Lodz, Poland, July 200

Tracing the Conversion of Gas into Stars in Young Massive Cluster Progenitors

Whilst young massive clusters (YMCs; $M$ $\gtrsim$ 10$^{4}$ M$_{\odot}$, age $\lesssim$ 100 Myr) have been identified in significant numbers, their progenitor gas clouds have eluded detection. Recently, four extreme molecular clouds residing within 200 pc of the Galactic centre have been identified as having the properties thought necessary to form YMCs. Here we utilise far-IR continuum data from the Herschel Infrared Galactic Plane Survey (HiGAL) and millimetre spectral line data from the Millimetre Astronomy Legacy Team 90 GHz Survey (MALT90) to determine their global physical and kinematic structure. We derive their masses, dust temperatures and radii and use virial analysis to conclude that they are all likely gravitationally bound -- confirming that they are likely YMC progenitors. We then compare the density profiles of these clouds to those of the gas and stellar components of the Sagittarius B2 Main and North proto-clusters and the stellar distribution of the Arches YMC. We find that even in these clouds -- the most massive and dense quiescent clouds in the Galaxy -- the gas is not compact enough to form an Arches-like ($M$ = 2x10$^{4}$ M$_{\odot}$, R$_{eff}$ = 0.4 pc) stellar distribution. Further dynamical processes would be required to condense the resultant population, indicating that the mass becomes more centrally concentrated as the (proto)-cluster evolves. These results suggest that YMC formation may proceed hierarchically rather than through monolithic collapse.Comment: 12 pages, 8 figures, 1 table. Accepted by MNRA

Mioma primario de la trompa de Falopio: una localización muy infrecuente

Indexación: Web of Science; Scielo.Presentamos un caso muy poco frecuente de mioma extrauterino, localizado en la trompa de Falopio derecha, en su porción media. A la inspección y anatomía patológica, no se encontraron evidencias de dependencia alguna con el útero. Constituyó un hallazgo en una mujer sometida a cirugía abdomino-pélvica debido a infertilidad primaria y dolor abdominal derecho. Los estudios previos con ultrasonido identificaron una imagen compatible con un mioma subseroso grande y pediculado.We present a rare case of extrauterine fibroid, located in the right fallopian tube in middle portion. The inspection and pathological study not found evidences of any dependence with uterus. It was a finding in a woman undergoing abdominal-pelvic surgery because of a primary infertility and right abdominal pain. Previous studies with ultrasound identified an image support a large pedicle subserous myoma.http://ref.scielo.org/g68cn

Estimating Gaps and Trends for the Chilean Economy

Trend GDP and the output gap are key inputs for policy evaluation and forecasting in standard models of monetary policy. However, the measurement of these variables is plagued with difficulties. In this paper we propose two different approaches. First, a data-based approach, that starts with the primal and dual estimates of total factor productivity (TFP) growth, and then uses a variety of procedures to filter the inputs. Second, a model-consistent framework that simultaneously estimates the macroeconomic dynamics and the underlying trends of the economy. We compare the difficulties in using each methodology, and we use them to construct measures of the output gap and potential growth for Chile