Modena 1182, the origins of a new paradigm of ownership : the interface between historical contingency and the scholarly invention of legal categories

The legal phrase dominium utile is commonly known to express the property rights enjoyed by the person to whom a piece of land has been granted in fief or under other similar concessions. A considerable amount of legal-historical research has been spent on the origins, the reasons and effects of this legal concept, which proved to have played a very significant role in European history. One of the results of this historical research was that the first jurist who introduced the expression dominium utile was Pillius de Medicina, a law professor who moved from Bologna to the new born school of Modena in 1180. This article aims at an historical recontextualization of Pillius’ doctrinal construct in the frame of the political and social history of the city of Modena. However, this contingency of a doctrinal invention does not prevent a legal theory from transcend its particular circumstances to remain part of the tool-box which can be used by intellectuals in a completely different historical context, perhaps very remote from time and place of their first origins.Publisher PDFPeer reviewe

Integration of Aerial Thermal Imagery, LiDAR Data and Ground Surveys for Surface Temperature Mapping in Urban Environments

A single-band surface temperature retrieval method is proposed, aiming at achieving a better accuracy by exploiting the integration of aerial thermal images with LiDAR data and ground surveys. LiDAR data allow the generation of a high resolution digital surface model and a detailed modeling of the Sky-View Factor (SVF). Ground surveys of surface temperature and emissivity, instead, are used to estimate the atmospheric parameters involved in the model (through a bounded least square adjustment) and for a first assessment of the accuracy of the results. The RMS of the difference between the surface temperatures computed from the model and measured on the check sites ranges between 0.8 \ub0C and 1.0 \ub0C, depending on the algorithm used to calculate the SVF. Results are in general better than the ones obtained without considering SVF and prove the effectiveness of the integration of different data sources. The proposed approach has the advantage of avoiding the modeling of the atmosphere conditions, which is often difficult to achieve with the desired accuracy; on the other hand, it is highly dependent on the accuracy of the data measured on the ground

A mini-ISY100 transposon delivery system effective in γ proteobacteria

Transposons are invaluable biological tools for the genetic manipulation of microorganisms. ISY100 from Synechocystis sp. PCC6803 is a member of the Tc1/mariner/IS630 superfamily, and is characterized by high transposition efficiency and a strong preference for TA target sequences. In this paper, we describe the design and application of a mini-ISY100 suicide vector for the in vivo creation of stable random transposon insertion libraries. The system was successfully applied in seven species belonging to four different orders of γ proteobacteria. In all cases, delivery using conjugation consistently showed the highest transposition efficiency compared to chemical transformation or electroporation. We determined the frequency of transposon insertions in all the species and proved the utility of the system by identifying genes involved in colony coloration in Shewanella oneidensis. The ease and the efficiency of the protocol developed here allow the creation of complete knock-out libraries in an extensive range of host microorganisms in less than a week with no requirement for preparatory modification

La Legge: dalle origini alla crisi

La legge, anche se non è più la fonte suprema, “resta comunque al centro del sistema delle fonti, perché è fondamentalmente rispetto ad essa che può determinarsi la posizione” di tutte le altre fonti. Un sintomo evidente di questa valenza evocativa della fonte legge e del suo nomen lo cogliamo nel Progetto di Trattato che adotta una Costituzione per l'Europa. In esso (artt. I-33 ss.), pur lasciando immutata la tipologia delle fonti (e i relativi problemi di deficit democratico) rispetto a quanto previsto nell’art. 249 Tr. Ce, si procede a modificare il loro nomen juris da “regolamento” e “direttiva” in “legge europea” e la “legge quadro europea”

La Legge: dalle origini alla crisi

La legge, anche se non è più la fonte suprema, “resta comunque al centro del sistema delle fonti, perché è fondamentalmente rispetto ad essa che può determinarsi la posizione” di tutte le altre fonti. Un sintomo evidente di questa valenza evocativa della fonte legge e del suo nomen lo cogliamo nel Progetto di Trattato che adotta una Costituzione per l'Europa. In esso (artt. I-33 ss.), pur lasciando immutata la tipologia delle fonti (e i relativi problemi di deficit democratico) rispetto a quanto previsto nell’art. 249 Tr. Ce, si procede a modificare il loro nomen juris da “regolamento” e “direttiva” in “legge europea” e la “legge quadro europea”

Abnormal temporal coupling of tactile perception and motor action in Parkinson's disease

Evidence shows altered somatosensory temporal discrimination threshold (STDT) in Parkinson's disease in comparison to normal subjects. In healthy subjects, movement execution modulates STDT values through mechanisms of sensory gating. We investigated whether STDT modulation during movement execution in patients with Parkinson's disease differs from that in healthy subjects. In 24 patients with Parkinson's disease and 20 healthy subjects, we tested STDT at baseline and during index finger abductions (at movement onset "0", 100, and 200 ms thereafter). We also recorded kinematic features of index finger abductions. Fifteen out of the 24 patients were also tested ON medication. In healthy subjects, STDT increased significantly at 0, 100, and 200 ms after movement onset, whereas in patients with Parkinson's disease in OFF therapy, it increased significantly at 0 and 100 ms but returned to baseline values at 200 ms. When patients were tested ON therapy, STDT during index finger abductions increased significantly, with a time course similar to that of healthy subjects. Differently from healthy subjects, in patients with Parkinson's disease, the mean velocity of the finger abductions decreased according to the time lapse between movement onset and the delivery of the paired electrical stimuli for testing somatosensory temporal discrimination. In conclusion, patients with Parkinson's disease show abnormalities in the temporal coupling between tactile information and motor outflow. Our study provides first evidence that altered temporal processing of sensory information play a role in the pathophysiology of motor symptoms in Parkinson's disease

Continuous enzyme-coupled assay of phosphate- or pyrophosphate-releasing enzymes

A coupled enzyme assay able to monitor the kinetics of reactions catalyzed by phosphate- or pyrophosphate-releasing enzymes is presented here. The assay is based on the concerted action of inorganic pyrophosphatase (PPase), purine nucleoside phosphorylase (PNPase), and xanthine oxidase (XOD). In the presence of phosphate, PNPase catalyzes the phosphorolysis of inosine, generating hypoxanthine, which is oxidized to uric acid by XOD. The uric acid accordingly formed can be spectrophotometrically monitored at 293 nm, taking advantage of a molar extinction coefficient which is independent of pH between 6 and 9. The coupled assay was tested using DNA polymerases as a model system. The activity of Klenow enzyme was quantitatively determined, and it was found in agreement with the corresponding activity determined by traditional methods. Moreover, the continuous coupled assay was used to determine K-m and V-max of Klenow enzyme, yielding values in good agreement with previous observations. Finally, the coupled assay was also used to determine the activity of partially purified DNA polymerases, revealing its potential use to monitor purification of phosphate- or pyrophosphate-releasing enzymes

Transarterial radioembolization for hepatocellular carcinoma: a review

Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is the second cause of death due to malignancy in the world. The treatment of HCC is complex and includes potentially curative and palliative approaches. However, both curative and palliative treatments for HCC are often associated with a not-completely favorable safety/efficacy ratio. Therefore, other treatment options appear necessary in clinical practice. Transarterial radioembolization has shown a promising efficacy in terms of disease control and is associated with a good safety profile. This review discusses the use of transarterial radioembolization in HCC, with a focus on the clinical aspects of this therapeutic strategy

CADASIL or MS? Consider “Red Flags” but Avoid a Misdiagnosis: Case Series of a Concomitant Diagnosis

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a monogenic autosome-dominant disease with chronic clinical course. Rarely, CADASIL may present with atypical relapsing-remitting manifestations, cerebral and spinal white matter lesions, mimicking inflammatory CNS disease as multiple sclerosis (MS). The rarely co-occurrence of MS and CADASIL may represent a hard challenging diagnosis even for an expert neurologist. Here, we present a case series of two patients with CADASIL showing MRI pattern overlapping MS. They were the only case of co-occurrence of CADASIL and MS in their own family. Both patients were treated with anti-inflammatory and anti-platelet drugs, mostly with good response. Pathogenic hypothesis highlights that genetic events, related to monogenic disease, may expose CNS antigens with a consequent self-immune attack. In CADASIL, the function of Notch3 receptor showed a consistent interplay with immune system activity. Indeed, certain mutations of Notch3 receptor show abnormal upregulation of specific pro-inflammatory patterns. However, even if it is not possible to determinate if the proinflammatory activity may be promoted by pathogenic mutations in Notch3, the "apparent" difference between MS and “inflammatory CADASIL” could be considered more semantic than etiologic