Euclid : Cosmological forecasts from the void size function

Peer reviewe

From Ivacaftor to Triple Combination: A Systematic Review of Efficacy and Safety of CFTR Modulators in People with Cystic Fibrosis

Over the last years CFTR (cystic fibrosis transmembrane conductance regulator) modulators have shown the ability to improve relevant clinical outcomes in patients with cystic fibrosis (CF). This review aims at a systematic research of the current evidence on efficacy and tolerability of CFTR modulators for different genetic subsets of patients with CF. Two investigators independently performed the search on PubMed and included phase 2 and 3 clinical trials published in the study period 1 January 2005\u201331 January 2020. A final pool of 23 papers was included in the systematic review for a total of 4219 patients. For each paper data of interest were extracted and reported in table. In terms of lung function, patients who had the most beneficial effects from CFTR modulation were those patients with one gating mutation receiving IVA (ivacaftor) and patients with p.Phe508del mutation, both homozygous and heterozygous, receiving ELX/TEZ/IVA (elexacaftor/tezacaftor/ivacaftor) had the most relevant beneficial effects in term of lung function, pulmonary exacerbation decrease, and symptom improvement. CFTR modulators showed an overall favorable safety profile. Next steps should aim to systematize our comprehension of scientific data of efficacy and safety coming from real life observational studie

Cosmic voids in modified gravity models with massive neutrinos

Cosmic voids are progressively emerging as a new viable cosmological probe. Their abundance and density profiles are sensitive to modifications of gravity, as well as to dark energy and neutrinos. The main goal of this work is to investigate the possibility of exploiting cosmic void statistics to disentangle the degeneracies resulting from a proper combination of f(R) modified gravity and neutrino mass. We use N-body simulations to analyse the density profiles and size function of voids traced by both dark matter particles and haloes. We find clear evidence of the enhancement of gravity in f(R) cosmologies in the void density profiles at z = 1. However, these effects can be almost completely overridden by the presence of massive neutrinos because of their thermal free streaming. Despite the limited volume of the analysed simulations does not allow us to achieve a statistically relevant abundance of voids larger than 40 Mpc h-1, we find that the void size function at high redshifts and for large voids is potentially an effective probe to disentangle these degenerate cosmological models, which is key in the prospective of the upcoming wide-field redshift surveys

Caracterização dos sistemas produtivos de bovinos leiteiros do município de Rondon do Pará, mesorregião Sudeste paraense.

Este trabalho caracteriza as propriedades leiterias de Rondon do Pará (04º46?45?S/48°04?00?W), Mesorregião Sudeste Paraense, estado do Pará, para auxiliar nas ações institucionais e políticas públicas, e dar suporte ao desenvolvimento da cadeia produtiva do leite. Os dados foram coletados em entrevistas realizadas em 55 propriedades leiteiras, em 2012, por pesquisadores da Embrapa Amazônia Oriental e alunos do Programa de Pós Graduação em Ciência Animal - UFPA/Embrapa Amazônia Oriental/UFRA. Inicialmente foram selecionadas cinco propriedades, cuja atividade leiteira é a principal fonte de sustento familiar, com auxílio de profissionais de instituições de extensão privadas e públicas. Posteriormente, outras propriedades foram recrutadas por meio da técnica de bola de neve, onde os produtores recomendavam outros, de mesmo perfil e dispostos a participar da pesquisa. As informações foram obtidas por técnicas de Diagnóstico Rápido Participativo (DRP), com entrevista livre e aplicação de questionário semiestruturado, com possibilidades dos produtores discorrerem sobre suas experiências, a partir do foco principal proposto, e permitir respostas livre e espontâneas. As questões foram agrupadas em nove partes: identificação da propriedade e proprietário; caracterização da propriedade; discriminação da exploração leiteira na propriedade; máquinas e equipamentos; instalações e benfeitorias rurais; sanidade do rebanho; procedimento de ordenha e manejo do rebanho; produção, comercialização e mão de obra; e informações adicionais. Os dados foram tabulados em planilha no programa Microsoft Excel 2010, para posterior análise. A produção leiteira do município estudado apresenta condições precárias, o que demonstra a necessidade da melhoria das instalações zootécnicas e manejo animal e principalmente assistência eficiente em relação às boas práticas na ordenha, bem como melhoria do sistema nutricional. O clima afeta, negativamente, a produção de forragem no decorrer do ano, fato que aliado à baixa adoção de tecnologias, reduz a produtividade média dos bovinos leiteiros das pequenas propriedades rurais

AMICO galaxy clusters in KiDS-DR3: cosmological constraints from counts and stacked weak-lensing

We present a cosmological analysis of abundances and stacked weak-lensing profiles of galaxy clusters, exploiting the AMICO KiDS-DR3 catalogue. The sample consists of 3652 galaxy clusters with intrinsic richness $\lambda^*\geq20$, over an effective area of 377 deg$^2$, in the redshift range $z\in[0.1,\,0.6]$. We quantified the purity and completeness of the sample through simulations. The statistical analysis has been performed by simultaneously modelling the comoving number density of galaxy clusters and the scaling relation between the intrinsic richnesses and the cluster masses, assessed through a stacked weak-lensing profile modelling. The fluctuations of the matter background density, caused by super-survey modes, have been taken into account in the likelihood. Assuming a flat $\Lambda$CDM model, we constrained $\Omega_{\rm m}$, $\sigma_8$, $S_8 \equiv \sigma_8(\Omega_{\rm m}/0.3)^{0.5}$, and the parameters of the mass-richness scaling relation. We obtained $\Omega_{\rm m}=0.24^{+0.03}_{-0.04}$, $\sigma_8=0.86^{+0.07}_{-0.07}$, $S_8=0.78^{+0.04}_{-0.04}$. The constraint on $S_8$ is consistent within 1$\sigma$ with the results from WMAP and Planck. Furthermore, we got constraints on the cluster mass scaling relation in agreement with those obtained from a previous weak-lensing only analysis.Comment: 12 pages, 7 figures, 2 tables. Accepted by A&

AMICO galaxy clusters in KiDS-DR3: Cosmological constraints from angular power spectrum and correlation function

We study the tomographic clustering properties of the photometric cluster catalogue derived from the Third Data Release of the Kilo Degree Survey, focusing on the angular correlation function and its spherical harmonic counterpart, the angular power spectrum. We measure the angular correlation function and power spectrum from a sample of 5162 clusters, with an intrinsic richness $\lambda^*\geq 15$, in the photometric redshift range $z\in [0.1, 0.6]$, comparing our measurements with theoretical models, in the framework of the $\Lambda$-Cold Dark Matter cosmology. We perform a Monte Carlo Markov Chain analysis to constrain the cosmological parameters $\Omega_{\mathrm{m}}$, $\sigma_8$ and the structure growth parameter $S_8\equiv\sigma_8 \sqrt{\Omega_{\mathrm{m}}/0.3}$. We adopt Gaussian priors on the parameters of the mass-richness relation, based on the posterior distributions derived from a previous joint analysis of cluster counts and weak lensing mass measurements carried out with the same catalogue. From the angular correlation function, we obtain $\Omega_{\mathrm{m}}=0.32^{+0.05}_{-0.04}$, $\sigma_8=0.77^{+0.13}_{-0.09}$ and $S_8=0.80^{+0.08}_{-0.06}$, in agreement, within $1\sigma$, with 3D clustering result based on the same cluster sample and with existing complementary studies on other datasets. For the angular power spectrum, we derive statistically consistent results, in particular $\Omega_{\mathrm{m}}=0.24^{+0.05}_{-0.04}$ and $S_8=0.93^{+0.11}_{-0.12}$, while the constraint on $\sigma_8$ alone is weaker with respect to the one provided by the angular correlation function, $\sigma_8=1.01^{+0.25}_{-0.17}$. Our results show that the 2D clustering from photometric cluster surveys can provide competitive cosmological constraints with respect to the full 3D clustering statistics, and can be successfully applied to ongoing and forthcoming spectro/photometric surveys.Comment: 14 pages, 9 figures. Submitted to Astronomy & Astrophysics (A&A