Community based trial of home blood pressure monitoring with nurse-led telephone support in patients with stroke or transient ischaemic attack recently discharged from hospital.

BACKGROUND: High blood pressure in patients with stroke increases the risk of recurrence but management in the community is often inadequate. Home blood pressure monitoring may increase patients' involvement in their care, increase compliance, and reduce the need for patients to attend their General Practitioner if blood pressure is adequately controlled. However the value of home monitoring to improve blood pressure control is unclear. In particular its use has not been evaluated in stroke patients in whom neurological and cognitive ability may present unique challenges. DESIGN: Community based randomised trial with follow up after 12 months. PARTICIPANTS: 360 patients admitted to three South London Stroke units with stroke or transient ischaemic attack within the past 9 months will be recruited from the wards or outpatients and randomly allocated into two groups. All patients will be visited by the specialist nurse at home at baseline when she will measure their blood pressure and administer a questionnaire. These procedures will be repeated at 12 months follow up by another researcher blind as to whether the patient is in intervention or control group. INTERVENTION: INTERVENTION patients will be given a validated home blood pressure monitor and support from the specialist nurse. Control patients will continue with usual care (blood pressure monitoring by their practice). Main outcome measures in both groups after 12 months: 1. Change in systolic blood pressure.2. Cost effectiveness: Incremental cost of the intervention to the National Health Service and incremental cost per quality adjusted life year gained

Discovery of hydrothermal vent Tantulocarida on a new genus of Argestidae (Copepoda: Harpacticoida)

Preliminary investigations of hydrothermal vent harpacticoids from the Galapagos Rift resulted in the discovery of a new genus and species of Tantulocarida. Rimitantulus hirsutus gen. et sp. nov. is described on the basis of the tantulus larva and the male at an early stage of development. It is the first record of the subclass from hydrothermal vent habitats and is placed in the Basipodellidae which exclusively utilize copepods as hosts. The harpacticoid host Argestoides prehensilis gen. et sp. nov., which is known only from the male, shows affinities with both the Ameiridae and Argestidae and is placed genus incertae sedis in the latter primarily on account of the complete lack of sexual dimorphism on the swimming legs

Higgsless GUT Breaking and Trinification

Boundary conditions on an extra-dimensional interval can be chosen to break bulk gauge symmetries and to reduce the rank of the gauge group. We consider this mechanism in models with gauge trinification. We determine the boundary conditions necessary to break the trinified gauge group directly down to that of the standard model. Working in an effective theory for the gauge symmetry-breaking parameters on a boundary, we examine the limit in which the GUT-breaking sector is Higgsless and show how one may obtain the low-energy particle content of the minimal supersymmetric standard model. We find that gauge unification is preserved in this scenario, and that the differential gauge coupling running is logarithmic above the scale of compactification. We compare the phenomenology of our model to that of four-dimensional trinified theories.Comment: 22 pages, LaTeX, 2 eps figures (v3: discussion of mass scales clarified

The Mid-IR Contribution Of Dust Enshrouded Stars In Six Nearby Galaxies

We measure the integrated contributions of dusty AGB stars and other luminous red mid-IR sources to the mid-IR luminosities of 6 galaxies (M81, NGC 2403, NGC 300, M33 and the Magellanic Clouds). We find the dusty AGB stars whose mid-IR fluxes are dominated by dust rather than photospheric emission contribute from 0.6% (M81) to 5.6% (SMC) of the 3.6 micron flux and 1.0% (M81) to 10.1% (SMC) of the 4.5 micron flux. We find a trend of decreasing AGB contribution with increasing galaxy metallicity, luminosity and mass and decreasing SSFR. However, these galaxy properties are strongly correlated in our sample and the simplest explanation of the trend is galaxy metallicity. Bright, red sources other than dusty AGB stars represent a smaller fraction of the luminosity, ~1.2% at 3.6 microns, however their dust is likely cooler and their contributions are likely larger at longer wavelengths. Excluding the SMC, the contribution from these red sources correlates with the specific star formation rate as we would expect for massive stars. In total, after correcting for dust emission at other wavelengths, the dust around AGB stars radiates 0.1-0.8% of the bolometric luminosities of the galaxies. Thus, hot dust emission from AGB and other luminous dusty stars represent a small fraction of the total luminosities of the galaxies but a significant fraction of their mid-IR emissions.Comment: 9 pages, 6 figures, published in ApJ. For a brief video explaining the key results of this paper, see http://www.youtube.com/user/OSUAstronom

Linking Antarctic krill larval supply and recruitment along the Antarctic Peninsula

Antarctic krill (Euphausia superba) larval production and overwinter survival drive recruitment variability, which in turn determines abundance trends. The Antarctic Peninsula has been described as a recruitment hot spot and as a potentially important source region for larval and juvenile krill dispersal. However, there has been no analysis to spatially resolve regional-scale krill population dynamics across life stages. We assessed spatiotemporal patterns in krill demography using two decades of austral summer data collected along the North and West Antarctic Peninsula since 1993. We identified persistent spatial segregation in the summer distribution of euphausiid larvae (E. superba plus other species), which were concentrated in oceanic waters along the continental slope, and E. superba recruits, which were concentrated in shelf and coastal waters. Mature females of E. superba were more abundant over the continental shelf than the slope or coast. Euphausiid larval abundance was relatively localized and weakly correlated between the North and West Antarctic Peninsula, while E. superba recruitment was generally synchronized throughout the entire region. Euphausiid larval abundance along the West Antarctic Peninsula slope explained E. superba recruitment in shelf and coastal waters the next year. Given the localized nature of krill productivity, it is critical to evaluate the connectivity between upstream and downstream areas of the Antarctic Peninsula and beyond. Krill fishery catch distributions and population projections in the context of a changing climate should account for ontogenetic habitat partitioning, regional population connectivity, and highly variable recruitment

Early respiratory viral infections in infants with cystic fibrosis

This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.Background Viral infections contribute to morbidity in cystic fibrosis (CF), but the impact of respiratory viruses on the development of airway disease is poorly understood. Methods Infants with CF identified by newborn screening were enrolled prior to 4 months of age to participate in a prospective observational study at 4 centers. Clinical data were collected at clinic visits and weekly phone calls. Multiplex PCR assays were performed on nasopharyngeal swabs to detect respiratory viruses during routine visits and when symptomatic. Participants underwent bronchoscopy with bronchoalveolar lavage (BAL) and a subset underwent pulmonary function testing. We present findings through 8.5 months of life. Results Seventy infants were enrolled, mean age 3.1 ± 0.8 months. Rhinovirus was the most prevalent virus (66%), followed by parainfluenza (19%), and coronavirus (16%). Participants had a median of 1.5 viral positive swabs (range 0–10). Past viral infection was associated with elevated neutrophil concentrations and bacterial isolates in BAL fluid, including recovery of classic CF bacterial pathogens. When antibiotics were prescribed for respiratory-related indications, viruses were identified in 52% of those instances. Conclusions Early viral infections were associated with greater neutrophilic inflammation and bacterial pathogens. Early viral infections appear to contribute to initiation of lower airway inflammation in infants with CF. Antibiotics were commonly prescribed in the setting of a viral infection. Future investigations examining longitudinal relationships between viral infections, airway microbiome, and antibiotic use will allow us to elucidate the interplay between these factors in young children with CF