13 research outputs found
The role of Lactoferrin in intestinal health
The intestine represents one of the first barriers where microorganisms and environmental antigens come into tight contact with the host immune system. A healthy intestine is essential for the well-being of humans and animals. The period after birth is a very important phase of development, as the infant moves from a protected environment in the uterus to one with many of unknown antigens and pathogens. In that period, mother’s milk plays an important role, as it contains an abundance of biologically active components. Among these components, the iron-binding glycoprotein, lactoferrin (LF), has demonstrated a variety of important benefits in infants and adults, including the promotion of intestinal health. This review article aims to provide a compilation of all the information related to LF and intestinal health, in infants and adults
Estudio comparativo de la recuperación postparto en base a los Patrones de Marjory Gordon
Objective: Analyse if there is any difference in recovery rate according to their puerperium stage depending on perineal lesion.Material and method: Prospective longitudinal descriptive quantitative study, following the Marjory Gordon’s Functional Health Patterns. Data collection will be performed in three phases (immediate, clinical and remote puerperium), through semi-structured interview completed in first instance in a face-to-face interview and phone call interview at 10 and 30 days, respectively. Results: In Spain there is an episiotomy, induction and assisted delivery rate much higher than recommended. Episiotomy technique lead to significant tear (16,7%) in this study. During immediate puerperium, women who were practiced an episiotomy shown mobility difficulties (p=0,0005), elimination (p=0,0007), baby care (p=0,015), rest (p=0,15) and perceived pain (p=0,005), whereas in the clinical puerperium are affected only mobility (p=0,05), elimination (p=0,042) and perceived pain (p=0,006). After 30 days, remote puerperium, there is not statistical significant differences in both groups. More research is needed to confirm these facts as well as provide new knowledge.Conclusions: Episiotomy produce more negative effects than spontaneous tears at the immediate and clinical puerperium of women. Pain produced by this technique as a short, medium and long term limit many daily activities of women.Objetivo: Analizar si existen diferencias en el nivel de recuperación en las distintas fases del puerperio según el tipo de lesión perineal.Material y método: Estudio cuantitativo de tipo descriptivo longitudinal prospectivo, siguiendo los Patrones Funcionales de Salud de Marjory Gordon. La recogida de datos se realiza en tres fases (puerperio inmediato, clÃnico y tardÃo), empleando entrevistas semiestructuradas que se completan en un primer momento en una entrevista personal y vÃa telefónica a los 10 y a los 30 dÃas, respectivamente.Resultados: En España existe un Ãndice de episiotomÃas, inducciones y partos instrumentales muy superior al recomendado. La técnica de la episiotomÃa produjo desgarros importantes (16,7%) en este estudio. Durante el puerperio inmediato, las mujeres con episiotomÃa tienen dificultades en la movilidad (p=0,0005), la eliminación (p=0,007), cuidado del bebé (p=0,015), descanso (p=0,15) y dolor percibido (p=0,005), mientras que en el puerperio clÃnico están afectados sólo la movilidad (p=0,05), la eliminación (p=0,042) y el dolor percibido (p=0,006). A los 30 dÃas, en el puerperio tardÃo, no existen diferencias estadÃsticamente significativas entre ambos grupos. Se necesitan más estudios que reafirmen estos hechos y aporten nuevos conocimientos.Conclusiones: La episiotomÃa produce más efectos negativos que los desgarros espontáneos en el puerperio inmediato y clÃnico en la mujer. El dolor que genera esta técnica a corto, medio y largo plazo es el que limita muchas de las actividades cotidianas de estas mujeres
Comparative Genomic Analysis of Human Fungal Pathogens Causing Paracoccidioidomycosis
Paracoccidioides is a fungal pathogen and the cause of paracoccidioidomycosis, a health-threatening human systemic mycosis endemic to Latin America. Infection by Paracoccidioides, a dimorphic fungus in the order Onygenales, is coupled with a thermally regulated transition from a soil-dwelling filamentous form to a yeast-like pathogenic form. To better understand the genetic basis of growth and pathogenicity in Paracoccidioides, we sequenced the genomes of two strains of Paracoccidioides brasiliensis (Pb03 and Pb18) and one strain of Paracoccidioides lutzii (Pb01). These genomes range in size from 29.1 Mb to 32.9 Mb and encode 7,610 to 8,130 genes. To enable genetic studies, we mapped 94% of the P. brasiliensis Pb18 assembly onto five chromosomes. We characterized gene family content across Onygenales and related fungi, and within Paracoccidioides we found expansions of the fungal-specific kinase family FunK1. Additionally, the Onygenales have lost many genes involved in carbohydrate metabolism and fewer genes involved in protein metabolism, resulting in a higher ratio of proteases to carbohydrate active enzymes in the Onygenales than their relatives. To determine if gene content correlated with growth on different substrates, we screened the non-pathogenic onygenale Uncinocarpus reesii, which has orthologs for 91% of Paracoccidioides metabolic genes, for growth on 190 carbon sources. U. reesii showed growth on a limited range of carbohydrates, primarily basic plant sugars and cell wall components; this suggests that Onygenales, including dimorphic fungi, can degrade cellulosic plant material in the soil. In addition, U. reesii grew on gelatin and a wide range of dipeptides and amino acids, indicating a preference for proteinaceous growth substrates over carbohydrates, which may enable these fungi to also degrade animal biomass. These capabilities for degrading plant and animal substrates suggest a duality in lifestyle that could enable pathogenic species of Onygenales to transfer from soil to animal hosts.National Institute of Allergy and Infectious Diseases (U.S.)National Institutes of Health. Department of Health and Human Services (contract HHSN266200400001C)National Institutes of Health. Department of Health and Human Services(contract HHSN2722009000018C)Brazil. National Council for Scientific and Technological Developmen
Comparative study analysing maternal recovery after childbirth according to Marjory Gordon’s Patterns
Objetivo: Analizar si existen diferencias en el nivel de recuperación en las distintas fases del puerperio según el tipo de lesión perineal.Material y método:Estudio cuantitativo de tipo descriptivo longitudinal prospectivo, siguiendo los Patrones Funcionales de Salud de Marjory Gordon. La recogida de datos se realiza en tres fases (puerperio inmediato, clÃnico y tardÃo), empleando entrevistas semiestructuradas que se completan en un primer momento en una entrevista personal y vÃa telefónica a los 10 y a los 30 dÃas, respectivamente.Resultados:En España existe un Ãndice de episiotomÃas, inducciones y partos instrumentales muy superior al recomendado. La técnica de la episiotomÃa produjo desgarros importantes (16,7%) en este estudio. Durante el puerperio inmediato, las mujeres con episiotomÃa tienen dificultades en la movilidad (p=0,0005), la eliminación (p=0,007), cuidado del bebé (p=0,015), descanso (p=0,15) y dolor percibido (p=0,005), mientras que en el puerperio clÃnico están afectados sólo la movilidad (p=0,05), la eliminación (p=0,042) y el dolor percibido (p=0,006). A los 30 dÃas, en el puerperio tardÃo, no existen diferencias estadÃsticamente significativas entre ambos grupos. Se necesitan más estudios que reafirmen estos hechos y aporten nuevos conocimientos.Conclusiones:La episiotomÃa produce más efectos negativos que los desgarros espontáneos en el puerperio inmediato y clÃnico en la mujer. El dolor que genera esta técnica a corto, medio y largo plazo es el que limita muchas de las actividades cotidianas de estas mujeres.ABSTRACT: Objective:Analyse if there is any difference in recovery rate according to their puerperium stage depending on perineal lesion.Material and method:Prospective longitudinal descriptive quantitative study, following the Marjory Gordon’s Functional Health Patterns. Data collection will be performed in three phases (immediate, clinical and remote puerperium), through semi-structured interview completed in first instance in a face-to-face interview and phone call interviewat 10 and 30 days, respectively. Results:In Spain there is an episiotomy, induction and assisted delivery rate much higher than recommended. Episiotomy technique lead to significant tear (16,7%) in this study. During immediate puerperium, women who were practiced an episiotomy shown mobility difficulties (p=0,0005), elimination (p=0,0007), baby care (p=0,015), rest (p=0,15) and perceived pain (p=0,005), whereas in the clinical puerperium are affected only mobility (p=0,05), elimination (p=0,042) and perceived pain (p=0,006). After 30 days, remotepuerperium, there is not statistical significant differences in both groups. More research is needed to confirm these facts as well as provide new knowledge.Conclusions:Episiotomy produce more negative effects than spontaneous tears at the immediate andclinical puerperium of women. Pain produced by this technique as a short, medium and long term limit many daily activities of women
Arylpyridines, arylpyrimidines and related compounds as potential modulator agents of the VEGF, hTERT and c-Myc oncogenes
Twenty-four derivatives structurally related to honokiol have been synthesized and biologically evaluated. IC50 values were determined towards the HT-29, MCF-7 and HEK-293 cell lines. Some of these derivatives exhibited comparable or lower IC50 values than honokiol towards the HT-29 and MCF-7 cell lines or else higher selectivity indexes than the natural product. Twelve selected derivatives were evaluated for their ability to inhibit the expression of the VEGFA, hTERT and c-Myc genes and also to inhibit the production of total c-Myc protein and the secretion of the VEGF protein. One of the most promising compounds, 3-(2,4-dimethoxyphenyl)pyridine, may be a good candidate for further studies as an anticancer agent as it is able to improve the effect shown by honokiol in downregulating all gene expression and protein production at a safe concentration for non-tumor cells
Plantando libros en nuestra imaginación
El objetivo de este proyecto es abordar la lectura en la edad más temprana para despertar la afición en los niños y desarrollar su capacidad de compresión. Para ello se trabajan distintas técnicas: lectura expresiva y comprensiva, lectura silábica y lectura reflexiva, creativa y crÃtica. Y desde distintos recursos como contactar con las editoriales para conocer las novedades; encuentros con algunos autores de cuentos y literatura infantil; lecturas animadas de cuentos en las aulas; visitas a las bibliotecas públicas más cercanas; participación en sus actividades; y fomentar el mayor uso de la biblioteca escolar para favorecer la actualización de los fondos y considerarla fuente de información primaria para documentar los trabajos escolares. El creciente interés por consultar libros en la biblioteca demuestra que potenciar la lectura en las edades más tempranas favorece una mejor comprensión del temario por tanto, evita el fracaso escolar. Aportan como anexo a esta memoria en soporte informático y manual distintos ejercicios, dibujos, redacciones y cuestionarios relacionados con las lecturas propuestas durante el proyecto..Madrid (Comunidad Autónoma). ConsejerÃa de Educación. Dirección General de Mejora de la Calidad de la EnseñanzaMadridMadrid (Comunidad Autónoma). Subdirección General de Formación del Profesorado. CRIF Las Acacias; General Ricardos 179 - 28025 Madrid; Tel. + 34915250893ES