¿Qué grado de conocimiento tienen los adolescentes acerca de los cosméticos y productos de higiene personal que utilizan habitualmente?

Hoy en día nos encontramos expuestos a una gran cantidad de productos tóxicos dentro de nuestros hogares, procedentes de varias fuentes. Los productos de higiene personal y cosmética, usados a diario, pueden ser una de estas fuentes de contaminación relevante para la salud de nuestros jóvenes, debido al gran incremento del consumo de este tipo de productos durante dicha época de la vida y a los múltiples productos químicos de origen sintético que contienen. Así pues, debido a las evidencias encontradas en varios estudios relacionando los químicos sintéticos con diferentes tipos de enfermedades, creemos que es de gran importancia una mayor investigación en este campo y la educación para la salud a la población joven

DInSAR coseismic deformation of the May 2011 Mw 5.1 Lorca earthquake, (Southern Spain)

The coseismic superficial deformation at the region of Lorca (Murcia, southeastern Spain) due to the Mw 5.1 earthquake on 11 May 2011 was characterized by a multidisciplinary team, integrating information from DInSAR, GPS and numerical modelling techniques. Despite the moderate magnitude of the event, quantitative information was obtained from the interferometric study of a pair of TerraSAR-X images. The DinSAR results defined the trace of the fault plane and evidenced uplift of the hanging wall block in agreement with the estimated deformation obtained through an elastic rupture dislocation numerical model. Meanwhile for the footwall block, interferometric results showed that tectonic deformation is masked by an important subsidence related to groundwater extraction previously identified at the area of study. Horizontal crustal deformation rates and velocity vectors,obtained from GPS stations existent at the area, were also coherent with the tectonic setting of the southern margin of the Iberian Peninsula and with the focal mechanism calculated or the Lorca event. The analysis of a continuous GPS site in Lorca showed good agreement with the horizontal NS direction component relative to the numerical model and tectonics of the region. This is the first time at this seismic active area that a multitechnique analysis has been performed immediately after the occurrence of a seismic event, comparing the existing deformation data with a theoretical numerical model based on estimated seismic rupture dislocation

Investigating the phytochemical, flavour and sensory at-tributes of mature and microgreen coriander (Coriandrum sativum).

Microgreens, young stem and leaves of growing plants, have recently been the subject of much interest due to their higher concentrations of nutritive and purported bioactive compounds in comparison to their mature plant counterparts. However, there is currently limited information available in relation to the flavour and sensory attributes of microgreen species, which may ultimately prove important in determining consumer acceptance. This paper reports the total phenolic, carotenoid and chlorophyll contents as well as the aroma volatile profile and sensory attributes of both mature and microgreen coriander. Microgreen coriander was shown to contain significantly higher levels of phenolic compounds, elevated concentrations of terpenes as the main aromatic compounds and a more intense bitter/sweet taste characteristics compared to the mature coriander

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Career management for UK food degree students at multiple institutes using an industry-developed professional competencies framework

Recruitment of food science and technology graduates remains a priority for the UK food industry in the wake of skills shortages. As a result of the contemporary pressures faced by the food industry, it is essential that students applying for such roles are aware of and ready for management, leadership, and relevant professional competencies. This collaborative study uses the industry-informed established framework, namely, Competencies for Food Graduate Careers (CFGC)and assesses the integration of this resource into careers education for food-related programs of four higher education institutions: Cardiff Metropolitan University, Sheffield Hallam University, University of Nottingham and University of Reading. Mixed method analysis was conducted with students prior to and on conclusion of the teaching sessions, including surveys and focus groups. Students confirmed that CFGC was informative and useful for preparing them for a graduate career in food science and technology. No single method of integration of CFGC was proposed; instead, intervention can be undertaken by a variety of approaches, suitable for the level of study and Institutional operation as outlined in the stud

Acute retinal necrosis in an acute leukemia pediatric patient Necrosis retinal aguda en un paciente pediátrico con leucemia aguda

Acute retinal necrosis (ARN) is a serious condition that can impair vision. It mostly occurs in adult patients, especially those severely immunocompromised, in association with a reactivation of a herpes virus infection. We present a 4 years old patient with high risk acute leukemia, whom during a course of intense chemotherapy acquired chickenpox with visceral involvement that affected the retina, causing unilateral blindness. Varicella-zoster virus was detected by PCR in the vitreous humor, in spite of previous acyclovir treatment. The contralateral vision remained undamaged

An exploration of EFL teachers' beliefs and practices of grammar instrucction in Chile

Tesis (Profesor de Inglés para la Enseñanza Básica y Media y al grado académico de Licenciado en Educación)This study investigated Chilean EFL teachers‘ beliefs and practices, how they relate to each other, and the gaps among them. Although much has been written about what teachers think and do inside the classroom, studies that explore these gaps are lacking. A mixed-methods approach incorporating a questionnaire, class observations and interviews allowed the researchers to obtain data regarding teachers‘ stated beliefs, classroom practices, personal views, and to compare and contrast them. Incongruities were found between teachers‘ cognitions and practices, which are analyzed with relation to previous findings in research and interviewees‘ views. The findings indicate that contextual factors, past experiences as learners and teachers, and the school and national curriculum have an actual impact on the teachers

DInSAR coseismic deformation of the May 2011 Mw 5.1 Lorca earthquake, (Southern Spain)

The coseismic superficial deformation at the region of Lorca (Murcia, southeastern Spain) due to the Mw 5.1 earthquake on 11 May 2011 was characterized by a multidisciplinary team, integrating information from DInSAR, GPS and numerical modelling techniques. Despite the moderate magnitude of the event, quantitative information was obtained from the interferometric study of a pair of TerraSAR-X images. The DinSAR results defined the trace of the fault plane and evidenced uplift of the hanging wall block in agreement with the estimated deformation obtained through an elastic rupture dislocation numerical model. Meanwhile for the footwall block, interferometric results showed that tectonic deformation is masked by an important subsidence related to groundwater extraction previously identified at the area of study. Horizontal crustal deformation rates and velocity vectors,obtained from GPS stations existent at the area, were also coherent with the tectonic setting of the southern margin of the Iberian Peninsula and with the focal mechanism calculated or the Lorca event. The analysis of a continuous GPS site in Lorca showed good agreement with the horizontal NS direction component relative to the numerical model and tectonics of the region. This is the first time at this seismic active area that a multitechnique analysis has been performed immediately after the occurrence of a seismic event, comparing the existing deformation data with a theoretical numerical model based on estimated seismic rupture dislocation