Cell therapy in patients with critical limb ischemia

Critical limb ischemia (CLI) represents the most advanced stage of peripheral arterial obstructive disease (PAOD) with a severe obstruction of the arteries which markedly reduces blood flow to the extremities and has progressed to the point of severe rest pain and/or even tissue loss. Recent therapeutic strategies have focused on restoring this balance in favor of tissue survival using exogenousmolecular and cellular agents to promote regeneration of the vasculature.These are based on stimulation of angiogenesis by extracellular and cellular components. This review article carries out a systematic analysis of the most recent scientific literature on the application of stem cells in patients with CLI. The results obtained from the detailed analysis of the recent literature data have confirmed the beneficial role of cell therapy in reducing the rate of major amputations in patients with CLI and improving their quality of life

Verifying for Compliance to Data Constraints in Collaborative Business Processes.

Production processes are nowadays fragmented across different companies and organized in global collaborative networks. This is the result of the first wave of globalization that, among the various factors, was enabled by the diffusion of Internet-based Information and Communication Technologies (ICTs) at the beginning of the years 2000. The recent wave of new technologies possibly leading to the fourth industrial revolution – the so-called Industry 4.0 – is further multiplying opportunities. Accessing global customers opens great opportunities for organizations, including small and medium enterprises (SMEs), but it requires the ability to adapt to different requirements and conditions, volatile demand patterns and fast-changing technologies. Regardless of the industrial sector, the processes used in an organization must be compliant to rules, standards, laws and regulations. Non-compliance subjects enterprises to litigation and financial fines. Thus, compliance verification is a major concern, not only to keep pace with changing regulations but also to address the rising concerns of security, product and service quality and data privacy. The software, in particular process automation, used must be designed accordingly. In relation to process management, we propose a new way to pro-actively check the compliance of current running business processes using Descriptive Logic and Linear Temporal Logic to describe the constraints related to data. Related algorithms are presented to detect the potential violations

SAT-based Model Checking for Security Protocols Analysis

We present a model checking technique for security protocols based on a reduction to propositional logic. At the core of our approach is a procedure that, given a description of the protocol in a multi-set rewriting formalism and a positive integer k, builds a propositional formula whose models (if any) correspond to attacks on the protocol. Thus, finding attacks on protocols boils down to checking a propositional formula for satisfiability, problem that is usually solved very efficiently by modern SAT solvers. Experimental results indicate that the approach scales up to industrial strength security protocols with performance comparable with (and in some cases superior to) that of other state-of-the-art protocol analysers

Bulwark: Holistic and verified security monitoring of web protocols

Modern web applications often rely on third-party services to provide their functionality to users. The secure integration of these services is a non-trivial task, as shown by the large number of attacks against Single Sign On and Cashier-as-a-Service protocols. In this paper we present Bulwark, a new automatic tool which generates formally verified security monitors from applied pi-calculus specifications of web protocols. The security monitors generated by Bulwark offer holistic protection, since they can be readily deployed both at the client side and at the server side, thus ensuring full visibility of the attack surface against web protocols. We evaluate the effectiveness of Bulwark by testing it against a pool of vulnerable web applications that use the OAuth 2.0 protocol or integrate the PayPal payment system

An Optimized Intruder Model for SAT-based Model-Checking of Security Protocols

AbstractIn previous work we showed that automatic SAT-based model-checking techniques based on a reduction of protocol (in)security problems to a sequence of propositional satisfiability problems can be used to effectively find attacks on protocols. In this paper we present an optimized intruder model that may lead in many cases to shorter attacks which can be detected in our framework by generating smaller propositional formulae. The key idea is to assume that some of the abilities of the intruder have instantaneous effect, whereas in the previously adopted approach all the abilities of the intruder were modeled as state transitions. This required non trivial extensions to the SAT-reduction techniques which are formally described in the paper. Experimental results indicate the advantages of the proposed optimization