Genetic differentiation of Anopheles gambiae populations from East and West Africa : comparison of microsatellite and allozyme loci

Genetic variation of #Anopheles gambiae$ was analysed to assess interpopulation divergence over a 6000 km distance using short tandem repeat (microsatellite) loci and allozyme loci. Differentiation of populations from Kenya and Senegal measured by allele length variation at five microsatellite loci was compared with estimates calculated from published data on six allozyme loci (Miles, 1978). The average Wright's F(ST) of microsatellite loci (0.016) was lower than that of allozymes (0.036). Slatkin's R(ST) values for microsatellite loci were generally higher than their F(ST) values, but the average R(ST) value was virtually identical (0.036) to the average allozyme F(ST). These low estimates of differentiation correspond to an effective migration index (Nm) larger than 3, suggesting that gene flow across the continent is only weakly restricted. Polymorphism of microsatellite loci was significantly higher than that of allozymes, probably because the former experience considerably higher mutation rates. That microsatellite loci did not measure greater interpopulation divergence than allozyme loci suggested constraints on microsatellite evolution. Alternatively, extensive mosquito dispersal, aided by human transportation during the last century, better explains the low differentiation and the similarity of estimates derived from both types of genetic markers. (Résumé d'auteur

Appropriateness of oral anticoagulants for long-term treatment of atrial fibrillation in older people: results of an evidence-based review and international consensus validation process (OAC-FORTA 2016)

Background: Age appropriateness of anticoagulants for stroke prevention in atrial fibrillation is uncertain. Objective: To review oral anticoagulants for the treatment of atrial fibrillation in older (age >65 years) people and to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability using the Fit-fOR-The-Aged (FORTA) classification. Methods: We performed a structured comprehensive review of controlled clinical trials and summaries of individual product characteristics to assess study and total patient numbers, quality of major outcome data and data of geriatric relevance. The resulting evidence was discussed in a round table with an interdisciplinary panel of ten European experts. Decisions on age appropriateness were made using a Delphi process. Results: For the eight drugs included, 380 citations were identified. The primary outcome results were reported in 32 clinical trials with explicit and relevant data on older people. Though over 24,000 patients aged >75/80 years were studied for warfarin, data on geriatric syndromes were rare (two studies reporting on frailty/falls/mental status) and missing for all other compounds. Apixaban was rated FORTA-A (highly beneficial). Other non-vitamin K antagonist oral anticoagulants (including low/high-intensity dabigatran and high-intensity edoxaban) and warfarin were assigned to FORTA-B (beneficial). Phenprocoumon, acenocoumarol and fluindione were rated FORTA-C (questionable), mainly reflecting the absence of data. Conclusions: All non-vitamin K antagonist oral anticoagulants and warfarin were classified as beneficial or very beneficial in older persons (FORTA-A or -B), underlining the overall positive assessment of the risk/benefit ratio for these drugs. For other vitamin-K antagonists regionally used in Europe, the lack of evidence should challenge current practice

Proteomic approaches to study cysteine oxidation: applications in neurodegenerative diseases

Oxidative stress appears to be a key feature of many neurodegenerative diseases either as a cause or consequence of disease. A range of molecules are subject to oxidation, but in particular, proteins are an important target and measure of oxidative stress. Proteins are subject to a range of oxidative modifications at reactive cysteine residues, and depending on the level of oxidative stress, these modifications may be reversible or irreversible. A range of experimental approaches has been developed to characterize cysteine oxidation of proteins. In particular, mass spectrometry-based proteomic methods have emerged as a powerful means to identify and quantify cysteine oxidation sites on a proteome scale; however, their application to study neurodegenerative diseases is limited to date. Here we provide a guide to these approaches and highlight the under-exploited utility of these methods to measure oxidative stress in neurodegenerative diseases for biomarker discovery, target engagement and to understand disease mechanisms

Excited B mesons from the lattice

We determine the energies of the excited states of a heavy-light meson $Q\bar{q}$, with a static heavy quark and light quark with mass approximately that of the strange quark from both quenched lattices and with dynamical fermions. We are able to explore the energies of orbital excitations up to L=3, the spin-orbit splitting up to L=2 and the first radial excitation. These $b \bar{s}$ mesons will be very narrow if their mass is less than 5775 MeV -- the $BK$ threshold. We investigate this in detail and present evidence that the scalar meson (L=1) will be very narrow and that as many as 6 $b \bar{s}$ excited states will have energies close to the $BK$ threshold and should also be relatively narrow.Comment: 17 pages, 6 ps figure

Light Gluinos and the Parton Structure of the Nucleon

We study the effects of light gluinos with mass below about 1 GeV on the nucleon parton densities and the running of alpha_(S). It is shown that from the available high-statistics DIS data no lower bound on the gluino mass can be derived. Also in the new kinematical region accessible at HERA the influence of such light gluinos on structure f unctions is found to be very small and difficult to detect. For use in more direct searches involving final state signatures we present a radiative estimate of the gluino distribution in the nucleon.Comment: 23 pages, LateX, 8 figures, MPI-PhT/94-22, LMU-3/9

Shock Treatment: Heavy Quark Drag in a Novel AdS Geometry

We calculate the drag force on a heavy quark hit by a shock wave, thus generalizing the strongly coupled AdS/CFT heavy quark drag calculations to both hot and cold nuclear matter. The derivation employs the trailing string configuration, similar to that used in the literature for a quark moving through a thermal medium, though in the shock metric the string profile is described by a much simpler analytic function. Our expression for the drag depends on the typical transverse momentum scale of the matter in the shock. For a thermal medium this scale becomes proportional to the temperature, making our drag coefficient and momentum limit of applicability identical to those found previously. As the shock wave can be composed of either thermalized or non-thermalized media, our derivation extends the existing drag calculations to the case of arbitrarily distributed matter.Comment: 17 pages, 4 figures. Added a clarifying figure in the Appendix and made some slight textual changes. This is an expanded version of the letter to be published in Physics Letters

Angular Distributions of Drell-Yan Lepton Pairs at the Tevatron: Order αs2\alpha_s^2 Corrections and Monte Carlo Studies

We investigate the angular distribution of the lepton pair in the process $p \bar{p} \rightarrow \gamma^{\ast} + X \rightarrow \ell^+\ell^- + X$, where the virtual photon is produced at high transverse momentum. The angular distribution of the leptons is very sensitive to possible nonperturbative effects, such as a nontrivial vacuum structure of QCD, and offers a good chance to test such effects. We present complete ${\cal O}(\alpha_s^2)$ calculations of the decay lepton distributions in the lepton pair rest frame. An order ${\cal O}(\alpha_s)$ Monte Carlo study of the lepton angular distributions, with acceptance cuts and energy resolution smearing applied to the leptons, is also presented.Comment: 26 pages (Revtex) plus 9 (uuencoded) postscript figures available as a compressed tar file at ftp://phenom.physics.wisc.edu/pub/preprints/madph-94-857-figs.tar.

Probing Heavy Higgs Boson Models with a TeV Linear Collider

The last years have seen a great development in our understanding of particle physics at the weak scale. Precision electroweak observables have played a key role in this process and their values are consistent, within the Standard Model interpretation, with a light Higgs boson with mass lower than about 200 GeV. If new physics were responsible for the mechanism of electroweak symmetry breaking, there would, quite generally, be modifications to this prediction induced by the non-standard contributions to the precision electroweak observables. In this article, we analyze the experimental signatures of a heavy Higgs boson at linear colliders. We show that a linear collider, with center of mass energy \sqrt{s} <= 1 TeV, would be very useful to probe the basic ingredients of well motivated heavy Higgs boson models: a relatively heavy SM-like Higgs, together with either extra scalar or fermionic degrees of freedom, or with the mixing of the third generation quarks with non-standard heavy quark modes.Comment: 21 page

Minimal Composite Higgs Model with Light Bosons

We analyze a composite Higgs model with the minimal content that allows a light Standard-Model-like Higgs boson, potentially just above the current LEP limit. The Higgs boson is a bound state made up of the top quark and a heavy vector-like quark. The model predicts that only one other bound state may be lighter than the electroweak scale, namely a CP-odd neutral scalar. Several other composite scalars are expected to have masses in the TeV range. If the Higgs decay into a pair of CP-odd scalars is kinematically open, then this decay mode is dominant, with important implications for Higgs searches. The lower bound on the CP-odd scalar mass is loose, in some cases as low as $\sim$ 100 MeV, being set only by astrophysical constraints.Comment: 33 pages, latex. Corrections in eqs. 3.21, 3.23, 4.1, 4.5-10. One figure adde

Static quantities of the W boson in the SU_L(3) X U_X(1) model with right-handed neutrinos

The static electromagnetic properties of the $W$ boson, $\Delta \kappa$ and $\Delta Q$, are calculated in the SU_L(3)} \times U_X(1) model with right-handed neutrinos. The new contributions from this model arise from the gauge and scalar sectors. In the gauge sector there is a new contribution from a complex neutral gauge boson $Y^0$ and a singly-charged gauge boson $Y^\pm$. The mass of these gauge bosons, called bileptons, is expected to be in the range of a few hundreds of GeV according to the current bounds from experimental data. If the bilepton masses are of the order of 200 GeV, the size of their contribution is similar to that obtained in other weakly coupled theories. However the contributions to both $\Delta Q$ and $\Delta \kappa$ are negligible for very heavy or degenerate bileptons. As for the scalar sector, an scenario is examined in which the contribution to the $W$ form factors is identical to that of a two-Higgs-doublet model. It is found that this sector would not give large corrections to $\Delta \kappa$ and $\Delta Q$.Comment: New material included. Final version to apppear in Physical Review