1,331 research outputs found
Relating hygroscopicity and composition of organic aerosol particulate matter
A hygroscopicity tandem differential mobility analyzer (HTDMA) was used to measure the water uptake (hygroscopicity) of secondary organic aerosol (SOA) formed during the chemical and photochemical oxidation of several organic precursors in a smog chamber. Electron ionization mass spectra of the non-refractory submicron aerosol were simultaneously determined with an aerosol mass spectrometer (AMS), and correlations between the two different signals were investigated. SOA hygroscopicity was found to strongly correlate with the relative abundance of the ion signal m/z 44 expressed as a fraction of total organic signal (f44). m/z 44 is due mostly to the ion fragment CO2+ for all types of SOA systems studied, and has been previously shown to strongly correlate with organic O/C for ambient and chamber OA. The analysis was also performed on ambient OA from two field experiments at the remote site Jungfraujoch, and the megacity Mexico City, where similar results were found. A simple empirical linear relation between the hygroscopicity of OA at subsaturated RH, as given by the hygroscopic growth factor (GF) or "Îșorg" parameter, and f44 was determined and is given by Îșorg=2.2Ăf44â0.13. This approximation can be further verified and refined as the database for AMS and HTDMA measurements is constantly being expanded around the world. The use of this approximation could introduce an important simplification in the parameterization of hygroscopicity of OA in atmospheric models, since f44 is correlated with the photochemical age of an air mass
Relating hygroscopicity and composition of organic aerosol particulate matter
A hygroscopicity tandem differential mobility analyzer (HTDMA) was used to measure the water uptake (hygroscopicity) of secondary organic aerosol (SOA) formed during the chemical and photochemical oxidation of several organic precursors in a smog chamber. Electron ionization mass spectra of the non-refractory submicron aerosol were simultaneously determined with an aerosol mass spectrometer (AMS), and correlations between the two different signals were investigated. SOA hygroscopicity was found to strongly correlate with the relative abundance of the ion signal m/z 44 expressed as a fraction of total organic signal (f44). m/z 44 is due mostly to the ion fragment CO2+ for all types of SOA systems studied, and has been previously shown to strongly correlate with organic O/C for ambient and chamber OA. The analysis was also performed on ambient OA from two field experiments at the remote site Jungfraujoch, and the megacity Mexico City, where similar results were found. A simple empirical linear relation between the hygroscopicity of OA at subsaturated RH, as given by the hygroscopic growth factor (GF) or "Ï°org" parameter, and f44 was determined and is given by Ï°org = 2.2 Ă f44 â 0.13. This approximation can be further verified and refined as the database for AMS and HTDMA measurements is constantly being expanded around the world. The use of this approximation could introduce an important simplification in the parameterization of hygroscopicity of OA in atmospheric models, since f44 is correlated with the photochemical age of an air mass
Challenges and perceptions of implementing mass testing, treatment and tracking in malaria control: a qualitative study in Pakro sub-district of Ghana.
BACKGROUND: Malaria remains endemic in Ghana despite several interventions. Studies have demonstrated very high levels of asymptomatic malaria parasitaemia in both under-five and school-age children. Mass testing, treatment and tracking (MTTT) of malaria in communities is being proposed for implementation with the argument that it can reduce parasite load, amplify gains from the other control interventions and consequently lead to elimination. However, challenges associated with implementing MTTT such as feasibility, levels of coverage to be achieved for effectiveness, community perceptions and cost implications need to be clearly understood. This qualitative study was therefore conducted in an area with on-going MTTT to assess community and health workers' perceptions about feasibility of scale-up and effectiveness to guide scale-up decisions. METHODS: This qualitative study employed purposive sampling to select the study participants. Ten focus group discussions (FGDs) were conducted in seven communities; eight with community members (nâ=â80) and two with health workers (nâ=â14). In addition, two in-depth interviews (IDI) were conducted, one with a Physician Assistant and another with a Laboratory Technician at the health facility. All interviews were recorded, transcribed, translated and analyzed using QSR NVivo 12. RESULTS: Both health workers and community members expressed positive perceptions about the feasibility of implementation and effectiveness of MTTT as an intervention that could reduce the burden of malaria in the community. MTTT implementation was perceived to have increased sensitisation about malaria, reduced the incidence of malaria, reduced household expenditure on malaria and alleviated the need to travel long distances for healthcare. Key challenges to implementation were doubts about the expertise of trained Community-Based Health Volunteers (CBHVs) to diagnose and treat malaria appropriately, side effects of Artemisinin-based Combination Therapies (ACTs) and misconceptions that CBHVs could infect children with epilepsy. CONCLUSION: The study demonstrated that MTTT was perceived to be effective in reducing malaria incidence and related hospital visits in participating communities. MTTT was deemed useful in breaking financial and geographical barriers to accessing healthcare. The interventions were feasible and acceptable to community members, despite observed challenges to implementation such as concerns about CBHVs' knowledge and skills and reduced revenue from internally generated funds (IGF) of the health facility
An improved quantitative measure of the tendency for volcanic ash plumes to form in water: implications for the deposition of marine ash beds
Laboratory experiments and numerical simulations have shown that volcanic ash particles immersed in water can either settle slowly and individually, or rapidly and collectively as particle-laden plumes. The ratio of timescales for individual and collective settling, in the form of analytical expressions, provides a dimensionless quantitative measure of the tendency for such plumes to grow and persist which has important implications for determining particle residence times and deposition rates. However, existing measures in the literature assume that collective settling obeys Stokes' law and is therefore controlled by the balance between gravitational forces and viscous drag, despite plume development actually being controlled by the balance between gravitational forces and inertial drag even in the absence of turbulence during early times. This paper presents a new measure for plume onset which takes into account the inertial drag-controlled (rather than viscous drag-controlled) nature of plume growth and descent. A parameter study comprising a set of numerical simulations of small-scale volcanic ash particle settling experiments highlights the effectiveness of the new measure and, by comparison with an existing measure in the literature, also demonstrates that the timescale of collective settling is grossly under-estimated when assuming that plume development is slowed by viscous drag. Furthermore, the formulation of the new measure means that the tendency for plumes to form can be estimated from the thickness and concentration of the final deposit; the magnitude and duration of particle flux across the water's surface do not need to be known. The measure therefore permits the residence times of particles in a large body of water to be more accurately and practically determined, and allows the improved interpretation of layers of volcaniclastic material deposited at the seabed
How does multiscale modelling and inclusion of realistic palaeobathymetry affect numerical simulation of the Storegga Slide tsunami?
AbstractThe âŒ8.15ka Storegga submarine slide was a large (âŒ3000km3), tsunamigenic slide off the coast of Norway. The resulting tsunami had run-up heights of around 10â20m on the Norwegian coast, over 12m in Shetland, 3â6m on the Scottish mainland coast and reached as far as Greenland. Accurate numerical simulations of Storegga require high spatial resolution near the coasts, particularly near tsunami run-up observations, and also in the slide region. However, as the computational domain must span the whole of the Norwegian-Greenland sea, employing uniformly high spatial resolution is computationally prohibitive. To overcome this problem, we present a multiscale numerical model of the Storegga slide-generated tsunami where spatial resolution varies from 500m to 50km across the entire Norwegian-Greenland sea domain to optimally resolve the slide region, important coastlines and bathymetric changes. We compare results from our multiscale model to previous results using constant-resolution models and show that accounting for changes in bathymetry since 8.15ka, neglected in previous numerical studies of the Storegga slide-tsunami, improves the agreement between the model and inferred run-up heights in specific locations, especially in the Shetlands, where maximum run-up height increased from 8m (modern bathymetry) to 13m (palaeobathymetry). By tracking the Storegga tsunami as far south as the southern North sea, we also found that wave heights were high enough to inundate Doggerland, an island in the southern North Sea prior to sea level rise over the last 8ka
Leptoproduction of Heavy Quarks in the Fixed and Variable Flavor Schemes
We compare the results of the fixed-flavor scheme calculation of Laenen,
Riemersma, Smith and van Neerven with the variable-flavor scheme calculation of
Aivazis, Collins, Olness and Tung for the case of neutral-current
(photon-mediated) heavy-flavor (charm and bottom) production. Specifically, we
examine the features of both calculations throughout phase space and compare
the structure function . We also analyze the dependence of on
the mass factorization scale . We find that the former is most applicable
near threshold, while the latter works well for asymptotic . The validity
of each calculation in the intermediate region is dependent upon the and
values chosen.Comment: LaTeX format, 19 pages, 20 figures in uuencoded format. Postscript
file available at ftp://smuphy.physics.smu.edu/usr/ftpdir/pub/paper
Reducing Constraints in a Higher Dimensional Extension of the Randall and Sundrum Model
In order to investigate the phenomenological implications of warped spaces in
more than five dimensions, we consider a dimensional extension to
the Randall and Sundrum model in which the space is warped with respect to a
single direction by the presence of an anisotropic bulk cosmological constant.
The Einstein equations are solved, giving rise to a range of possible spaces in
which the additional spaces are warped. Here we consider models in
which the gauge fields are free to propagate into such spaces. After carrying
out the Kaluza Klein (KK) decomposition of such fields it is found that the KK
mass spectrum changes significantly depending on how the additional
dimensions are warped. We proceed to compute the lower bound on the KK mass
scale from electroweak observables for models with a bulk
gauge symmetry and models with a bulk gauge
symmetry. It is found that in both cases the most favourable bounds are
approximately TeV, corresponding to a mass of the first gauge
boson excitation of about 4-6 TeV. Hence additional warped dimensions offer a
new way of reducing the constraints on the KK scale.Comment: 27 pages, 15 figures, v3: Additional comments in sections 1, 2 and 4.
New appendix added. Five additional figures. References adde
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Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.
Brain morphogenesis is an important process contributing to higher-order cognition, however our knowledge about its biological basis is largely incomplete. Here we analyze 118 neuroanatomical parameters in 1,566 mutant mouse lines and identify 198 genes whose disruptions yield NeuroAnatomical Phenotypes (NAPs), mostly affecting structures implicated in brain connectivity. Groups of functionally similar NAP genes participate in pathways involving the cytoskeleton, the cell cycle and the synapse, display distinct fetal and postnatal brain expression dynamics and importantly, their disruption can yield convergent phenotypic patterns. 17% of human unique orthologues of mouse NAP genes are known loci for cognitive dysfunction. The remaining 83% constitute a vast pool of genes newly implicated in brain architecture, providing the largest study of mouse NAP genes and pathways. This offers a complementary resource to human genetic studies and predict that many more genes could be involved in mammalian brain morphogenesis
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones
Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein
scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot
(BRP) and RIM-binding protein (RBP). We here demonstrate axonal co-transport
of BRP and RBP using intravital live imaging, with both proteins co-
accumulating in axonal aggregates of several transport mutants. RBP, via its
C-terminal Src-homology 3 (SH3) domains, binds Aplip1/JIP1, a transport
adaptor involved in kinesin-dependent SV transport. We show in atomic detail
that RBP C-terminal SH3 domains bind a proline-rich (PxxP) motif of
Aplip1/JIP1 with submicromolar affinity. Pointmutating this PxxP motif
provoked formation of ectopic AZ-like structures at axonal membranes. Direct
interactions between AZ proteins and transport adaptors seem to provide
complex avidity and shield synaptic interaction surfaces of pre-assembled
scaffold protein transport complexes, thus, favouring physiological synaptic
AZ assembly over premature assembly at axonal membranes. - See more at:
http://elifesciences.org/content/4/e06935#sthash.oVGZ8cdi.dpu
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