8,259 research outputs found
Spectral properties of some West Coast waters and their relationship with dissolved organic carbon
Pattern formation by lateral inhibition with feedback: a mathematical model of Delta-Notch intercellular signalling
In many developing tissues, adjacent cells diverge in character so as to create a fine-grained pattern of cells in contrasting states of differentiation. It has been proposed that such patterns can be generated through lateral inhibitionâa type cellsâcell interaction whereby a cell that adopts a particular fate inhibits its immediate neighbours from doing likewise. Lateral inhibition is well documented in flies, worms and vertebrates. In all of these organisms, the transmembrane proteins Notch and Delta (or their homologues) have been identified as mediators of the interactionâNotch as receptor, Delta as its ligand on adjacent cells. However, it is not clear under precisely what conditions the Delta-Notch mechanism of lateral inhibition can generate the observed types of pattern, or indeed whether this mechanism is capable of generating such patterns by itself. Here we construct and analyse a simple and general mathematical model of such contact-mediated lateral inhibition. In accordance with experimental data, the model postulates that receipt of inhibition (i.e. activation of Notch) diminishes the ability to deliver inhibition (i.e. to produce active Delta). This gives rise to a feedback loop that can amplify differences between adjacent cells. We investigate the pattern-forming potential and temporal behavior of this model both analytically and through numerical simulation. Inhomogeneities are self-amplifying and develop without need of any other machinery, provided the feedback is sufficiently strong. For a wide range of initial and boundary conditions, the model generates fine-grained patterns similar to those observed in living systems
The smartlock hybrid maxillo-mandibular fixation system â A new device for mandibular-maxillary fixation
A search for starlight reflected from HD 75289 b
We have used a doppler tomographic analysis to conduct a deep search for the
starlight reflected from the planetary companion to HD 75289. In 4 nights on
VLT2/UVES in January 2003, we obtained 684 high resolution echelle spectra with
a total integration time of 26 hours. We establish an upper limit on the
planet's geometric albedo p < 0.12 (to the 99.9% significance level) at the
most probable orbital inclination i ~ 60 degrees, assuming a grey albedo, a
Venus-like phase function and a planetary radius R_p = 1.6 R_Jup. We are able
to rule out some combinations of the predicted planetary radius and atmospheric
albedo models with high, reflective cloud decks.Comment: 5 pages, 5 figures, MNRAS accepted 12 Oct 200
Identification of Bacterial Pathogens of Poultry by Practicing Veterinarians
Since diagnosis is paramount to the solution of a poultry disease problem, the experienced practitioner realizes that he cannot rely entirely on a good case history, symptoms and lesions found at necropsy to establish a positive diagnosis in many instances. The alert veterinarian soon learns that various diseases may manifest themselves in a similar manner. In such cases a differential diagnosis is essential if subsequent treatment, control measures and eradications are to be effective
Automatic, fast and robust characterization of noise distributions for diffusion MRI
Knowledge of the noise distribution in magnitude diffusion MRI images is the
centerpiece to quantify uncertainties arising from the acquisition process. The
use of parallel imaging methods, the number of receiver coils and imaging
filters applied by the scanner, amongst other factors, dictate the resulting
signal distribution. Accurate estimation beyond textbook Rician or noncentral
chi distributions often requires information about the acquisition process
(e.g. coils sensitivity maps or reconstruction coefficients), which is not
usually available. We introduce a new method where a change of variable
naturally gives rise to a particular form of the gamma distribution for
background signals. The first moments and maximum likelihood estimators of this
gamma distribution explicitly depend on the number of coils, making it possible
to estimate all unknown parameters using only the magnitude data. A rejection
step is used to make the method automatic and robust to artifacts. Experiments
on synthetic datasets show that the proposed method can reliably estimate both
the degrees of freedom and the standard deviation. The worst case errors range
from below 2% (spatially uniform noise) to approximately 10% (spatially
variable noise). Repeated acquisitions of in vivo datasets show that the
estimated parameters are stable and have lower variances than compared methods.Comment: v2: added publisher DOI statement, fixed text typo in appendix A
Lunar Surface Potential Changes Possible Associated with Traversals of the Bow Shock
We report an analysis of seven Apollo 14 Apollo Lunar Surface Experiments Package (ALSEP) Suprathermal Ion Detector Experiment (SIDE) "resonance" events from January 1972 through January 1973. The events appear to be associated with traversals of the Moon through the terrestrial bow shock
Inferring coronal structure from X-ray lightcurves and Doppler shifts: a Chandra study of AB Doradus
The Chandra X-ray observatory monitored the single cool star, AB Doradus,
continuously for a period lasting 88 ksec (1.98 Prot) in 2002 December with the
LETG/HRC-S. The X-ray lightcurve shows rotational modulation, with three peaks
that repeat in two consecutive rotation cycles. These peaks may indicate the
presence of compact emitting regions in the quiescent corona. Centroid shifts
as a function of phase in the strongest line profile, O VIII 18.97 A, indicate
Doppler rotational velocities with a semi-amplitude of 30 +/- 10 km/s. By
taking these diagnostics into account along with constraints on the rotational
broadening of line profiles (provided by archival Chandra HETG Fe XVII and FUSE
Fe XVIII profile) we can construct a simple model of the X-ray corona that
requires two components. One of these components is responsible for 80% of the
X-ray emission, and arises from the pole and/or a homogeneously distributed
corona. The second component consists of two or three compact active regions
that cause modulation in the lightcurve and contribute to the O VIII centroid
shifts. These compact regions account for 16% of the emission and are located
near the stellar surface with heights of less than 0.3R*. At least one of the
compact active regions is located in the partially obscured hemisphere of the
inclined star, while one of the other active regions may be located at 40
degrees. High quality X-ray data such as these can test the models of the
coronal magnetic field configuration as inferred from magnetic Zeeman Doppler
imaging.Comment: 28 pages, 11 figures, accepted by Ap
Folding of a donorâacceptor polyrotaxane by using noncovalent bonding interactions
Mechanically interlocked compounds, such as bistable catenanes and bistable rotaxanes, have been used to bring about actuation in nanoelectromechanical systems (NEMS) and molecular electronic devices (MEDs). The elaboration of the structural features of such rotaxanes into macromolecular materials might allow the utilization of molecular motion to impact their bulk properties. We report here the synthesis and characterization of polymers that contain Ï electron-donating 1,5-dioxynaphthalene (DNP) units encircled by cyclobis(paraquat-p-phenylene) (CBPQT4+), a Ï electron-accepting tetracationic cyclophane, synthesized by using the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The polyrotaxanes adopt a well defined âfoldedâ secondary structure by virtue of the judicious design of two DNP-containing monomers with different binding affinities for CBPQT4+. This efficient approach to the preparation of polyrotaxanes, taken alongside the initial investigations of their chemical properties, sets the stage for the preparation of a previously undescribed class of macromolecular architectures
The first magnetic maps of a pre-main sequence binary star system - HD 155555
We present the first maps of the surface magnetic fields of a pre-main
sequence binary system. Spectropolarimetric observations of the young, 18 Myr,
HD 155555 (V824 Ara, G5IV + K0IV) system were obtained at the Anglo-Australian
Telescope in 2004 and 2007. Both datasets are analysed using a new binary
Zeeman Doppler imaging (ZDI) code. This allows us to simultaneously model the
contribution of each component to the observed circularly polarised spectra.
Stellar brightness maps are also produced for HD 155555 and compared to
previous Doppler images. Our radial magnetic maps reveal a complex surface
magnetic topology with mixed polarities at all latitudes. We find rings of
azimuthal field on both stars, most of which are found to be non-axisymmetric
with the stellar rotational axis. We also examine the field strength and the
relative fraction of magnetic energy stored in the radial and azimuthal field
components at both epochs. A marked weakening of the field strength of the
secondary star is observed between the 2004 and 2007 epochs. This is
accompanied by an apparent shift in the location of magnetic energy from the
azimuthal to radial field. We suggest that this could be indicative of a
magnetic activity cycle. We use the radial magnetic maps to extrapolate the
coronal field (by assuming a potential field) for each star individually - at
present ignoring any possible interaction. The secondary star is found to
exhibit an extreme tilt (~75 deg) of its large scale magnetic field to that of
its rotation axis for both epochs. The field complexity that is apparent in the
surface maps persists out to a significant fraction of the binary separation.
Any interaction between the fields of the two stars is therefore likely to be
complex also. Modelling this would require a full binary field extrapolation.Comment: 17 pages, 12 figures, accepted for publication in MNRA
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