Perfil dos casos envolvendo glifosato registrados pelo Centro de Informações Toxicológicas de Santa Catarina

Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina. Departamento de Tocoginecologia

Conformação a frio de pré-formas sinterizadas de ferro puro e da liga Fe-3,5%Ni /

Dissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico.O objetivo do trabalho foi associar o comportamento mecânico estático do material à sua microestrutura e às condições de processamento. Como matéria prima para a fabricação das amostras utilizou-se pó de ferro atomizado Ancorsteel 1000B e pó de níquel carbonila. A pré-sinterização das pré-formas foi realizada nas temperaturas de 680oC, 880 oC, 950 oC e 1120 oC, por 30 minutos, em atmosfera de hidrogênio. Após a pré-sinterização as amostras foram forjadas a frio com 40% de deformação verdadeira, em recalque (upsetting), e sinterizadas (sinterização final) a 850 oC e 1120 oC, por 30 minutos. Os melhores resultados de propriedades mecânicas estáticas foram atingidos com pré-formas de ferro pré-sinterizadas a 880 oC e pré-formas da liga Fe + 3,5% Ni pré-sinterizadas a 680 oC, ou seja, nas temperaturas que conferem maior densificação no forjamento posterior. A recristalização que ocorre durante a sinterização final, após forjamento a frio, aumenta a cinética do processo. O percentual volumétrico de poros, o tamanho, a forma e a dimensão maior dos poros é variável conforme a região da peça e tipo de tensões sofridas durante o forjamento a frio, em cada região. Estas diferenças e seus efeitos devem, portanto, ser previstos no projeto de pré-formas, considerando as regiões mais solicitadas das peças em serviço

Brazilian version of Calgary-Cambridge Observation Guide 28-item version: cross-cultural adaptation and psychometric properties

OBJECTIVES: The search for appropriate tools to assess communicational skills remains an ongoing challenge. The Calgary-Cambridge Observation Guide (CCOG) 28-item version can measure and compare performance in communication skills training. Our goal was to adapt this version of the CCOG for the Brazilian cultural context and perform a psychometric quality analysis of the instrument. METHODS: Experienced preceptors (35) assessed videos of five medical residents with a simulated patient using the translated guide. For the cultural adaptation, we followed the methodological norms on synthesis, retrotranslation, committee review, and testing. We obtained validity evidence for the CCOG 28-item version using confirmatory factor analysis and the Many-Facet Rasch Model (MFRM). RESULTS: Confirmatory factor analysis indicated an adequate level of goodness-of-fit. The MFRM reliability coefficient was high in all facets, namely assessors (0.90), stations (0.99), and items (0.98). The assessors had greater difficulty with attitudinal items, such as demonstration of respect, confidence, and empathy. CONCLUSIONS: The psychometric indicators of the tool were adequate, a good potential for reproducing its Brazilian version as well as acceptable reliability for its use

The threshold for the constrained Ramsey property

Given graphs $G$, $H_1$, and $H_2$, let $G\xrightarrow{\text{mr}}(H_1,H_2)$ denote the property that in every edge colouring of $G$ there is a monochromatic copy of $H_1$ or a rainbow copy of $H_2$. The constrained Ramsey number, defined as the minimum $n$ such that $K_n\xrightarrow{\text{mr}}(H_1,H_2)$, exists if and only if $H_1$ is a star or $H_2$ is a forest. We determine the threshold for the property $G(n,p)\xrightarrow{\text{mr}}(H_1,H_2)$ when $H_2$ is a forest, explicitly when the threshold is $\Omega(n^{-1})$ and implicitly otherwise.Comment: 15 page

Opening the black box of selection

Peer reviewedPublisher PD

The Generic Structure Editor

AbstractThe ASF+SDF Meta-environment is an algebraic specification environment geared to language design, and a generator for interactive programming environments for these languages. During a reengineering project of the tooling of this system problems arose: the functionality was distributed over several tools, but the system as a whole contained a deadlock. This document reports on how PSF and Synchronous Interworkings were used to model the interaction of the tools, and to clarify the communication behaviour of the tools to the ASF+SDF engineering team

3D printed matrix solid forms : can the drug solubility and dose customisation affect their controlled release behaviour?

The use of 3D printing in pharmaceutics has grown over the last years, along with the number of studies on the impact of the composition of these formulations on their pharmaceutical and biopharmaceutical properties. Recently, we reported the combined effect of the infill percentage and the presence of a pore former on the drug release behaviour of 3D printed matrix solid forms prepared by fused deposition modelling. However, there are some open questions about the effect of the drug solubility and the size of these dosage forms on their controlled release properties. Therefore, we produced poly(Ɛ-caprolactone) filaments containing different soluble forms of dexamethasone (free acid, DEX; acetate ester, DEX-A; and phosphate salt, DEX-P), which showed suitable mechanical properties and printability. 3D printed solid forms were produced in two different sizes. The formulations composed of DEX-P released about 50% of drug after 10 h, while those containing DEX or DEX-A released about 9%. The drug release profiles from the 3D printed forms containing the same drug form but with different sizes were almost completely overlapped. Therefore, these 3D printed matrix solid forms can have their drug content customised by adjusting their size, without changing their controlled release behaviour

Experimental Validation of a Novel Methodology for Fast an Accurate Analysis of Solar Energy Yields Based on Cluster Analysis

The design and optimization of solar power systems requires a detailed knowledge of the dynamic behavior of the meteorology at the site of interest, usually assess by one typical meteorological year (TMY). Even with today’s technology, the computational effort to simulate solar energy system performance with one year of data at high frequency (as 1-min) may become colossal if a multivariable optimization has to be performed. This work evaluates a methodology based on cluster analysis for selecting number of individual days able to represent the long-term performance of a solar energy system. This procedure permits to drastically reduce computational effort related to the calculation of a solar power plant energy yield by simulating a reduced number of days from a TMY, facilitating a fast and optimal design of the plant