Interventions to increase uptake of the human papillomavirus vaccine in unvaccinated college students: A systematic literature review

© 2019, American Association of Colleges of Pharmacy. All rights reserved. The Committee was charged with the responsibility for examining the need for change in pharmacy education and the models of leadership that would enable that change to occur across the academy. They also examined the question of faculty wellbeing in a time of change and made several recommendations and suggestions regarding both charges. Building upon the work of the previous Academic Affairs Committee, the 2018-19 AAC encourages the academy to implement new curricular models supporting personalized learning that creates engaged and lifelong learners. This will require transformational leadership and substantial investments in faculty development and new assessment strategies and resources. Recognizing that the magnitude of the recommended change will produce new stress on faculty, the committee identified the need for much additional work on student, faculty and leaders’ wellbeing, noting the limited amount of empirical evidence on pharmacy related to stress and resilience. That said, if faculty and administrators are not able to address personal and community wellbeing, their ability to support their students’ wellbeing will be compromised

Intervening for exhaustion

"The search for psychosocial factors that contribute to the aetiology and course of coronary heart disease (CHD) has been an energetic, although not always fruitful, pursuit for more than half a century. Around 20 years ago, Appels [1] identified a prodromal constellation of symptoms, including physical exhaustion and feelings of hopelessness, that preceded major CHD events. It was hypothesized that this syndrome of “vital exhaustion” (VE) was a causal risk factor for CHD events, and several observational studies demonstrating prospective associations between VE and subsequent events have been adduced as supporting the hypothesis [2], [3], [4] and [5]. In a recent commentary, however, we discussed the difficulties inherent in drawing causal conclusions from observational evidence [6]. Applying general arguments that are by now very well rehearsed [7] and [8], we suggested that considerations such as confounding by common antecedents of both VE and CHD and reverse causation could not be readily dismissed and resolution was likely only following experimental studies. For example, an explanation of these prospective associations that regards CHD events as the result of inflammatory processes involved in the progress of atherosclerosis and VE as a consequence of such processes is just as parsimonious as one that regards VE as a causal risk. It is also equally, if not more, plausible biologically; there is now substantial evidence that inflammatory cytokines communicate with the central nervous system contributing to illness behaviour and experience and fostering feelings of depression and fatigue [9]. We also posed the question of what implications do the results of observational studies of VE hold for treatment [6]. Again, we would argue that in the absence of experimental evidence, the implications are extremely limited."\ud \u

Feasibility of Enceladus plume biosignature analysis: Successful capture of organic ice particles in hypervelocity impacts

Enceladus is a compelling destination for astrobiological analyses due to the presence of simple and complex organic constituents in cryovolcanic plumes that jet from its subsurface ocean. Enceladus plume capture during a flyby or orbiter mission is an appealing method for obtaining pristine ocean samples for scientific studies of this organic content because of the high science return, reduced planetary protection challenges, and lower risk and expense compared to a landed mission. However, this mission profile requires sufficient amounts of plume material for sensitive analysis. To explore the feasibility and optimization of the required capture systems, light gas gun experiments were carried out to study organic ice particle impacts on indium surfaces. An organic fluorescent tracer dye, Pacific Blue™, was dissolved in borate buffer and frozen into saline ice projectiles. During acceleration, the ice projectile breaks up in flight into micron‐sized particles that impact the target. Quantitative fluorescence microscopic analysis of the targets demonstrated that under certain impact conditions, 10–50% of the entrained organic molecules were captured in over 25% of the particle impacts. Optimal organic capture was observed for small particles (d ~ 5–15 µm) with velocities ranging from 1 to 2 km s$^{−1}$. Our results reveal how organic capture efficiency depends on impact velocity and particle size; capture increases as particles get smaller and as velocity is reduced. These results demonstrate the feasibility of collecting unmodified organic molecules from the Enceladus ice plume for sensitive analysis with modern in situ instrumentation such as microfluidic capillary electrophoresis (CE) analysis with ppb organic sensitivity

Sexual functioning among young adult cancer patients: A 2â year longitudinal study

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141907/1/cncr31030_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141907/2/cncr31030.pd

Spatial and kinematic segregation in star-cluster merger remnants

Globular clusters that exhibit chemical and dynamical complexity have been suggested to be the stripped nuclei of dwarf galaxies(e.g. M54, ω Cen). We use N-body simulations of nuclear star clusters forming via the mergers of star clusters to explore the persistence of substructure in the phase space. We find that the observed level of differentiation is difficult to reconcile with the observed if nuclear clusters form wholly out of the mergers of star clusters. Only the star clusters that merged most recently retain sufficiently distinct density and kinematics to be distinguishable from the rest of the nuclear cluster. In situ star formation must therefore be included to explain the observed properties of nuclear star clusters, in good agreement with previous results

Conflict monitoring and emotional processing in 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine users – A comparative neurophysiological study

In stimulant use and addiction, conflict control processes are crucial for regulating substance use and sustaining abstinence, which can be particularly challenging in social-affective situations. Users of methamphetamine (METH, “Ice”) and 3,4-methylenedioxymethamphetamine (MDMA, “Ecstasy”) both experience impulse control deficits, but display different social-affective and addictive profiles. We thus aimed to compare the effects of chronic use of the substituted amphetamines METH and MDMA on conflict control processes in different social-affective contexts (i.e., anger and happiness) and investigate their underlying neurophysiological mechanisms. For this purpose, chronic but recently abstinent users of METH (n = 38) and MDMA (n = 42), as well as amphetamine-naïve healthy controls (n = 83) performed an emotional face-word Stroop paradigm, while event-related potentials (ERPs) were recorded. Instead of substance-specific differences, both MDMA and METH users showed smaller behavioral effects of cognitive-emotional conflict processing (independently of emotional valence) and selective deficits in emotional processing of anger content. Both effects were underpinned by stronger P3 ERP modulations suggesting that users of substituted amphetamines employ altered stimulus–response mapping and decision-making. Given that these processes are modulated by noradrenaline and that both MDMA and METH use may be associated with noradrenergic dysfunctions, the noradrenaline system may underlie the observed substance-related similarities. Better understanding the functional relevance of this currently still under-researched neurotransmitter and its functional changes in chronic users of substituted amphetamines is thus an important avenue for future research

IDOL regulates systemic energy balance through control of neuronal VLDLR expression.

Liver X receptors limit cellular lipid uptake by stimulating the transcription of Inducible Degrader of the LDL Receptor (IDOL), an E3 ubiquitin ligase that targets lipoprotein receptors for degradation. The function of IDOL in systemic metabolism is incompletely understood. Here we show that loss of IDOL in mice protects against the development of diet-induced obesity and metabolic dysfunction by altering food intake and thermogenesis. Unexpectedly, analysis of tissue-specific knockout mice revealed that IDOL affects energy balance, not through its actions in peripheral metabolic tissues (liver, adipose, endothelium, intestine, skeletal muscle), but by controlling lipoprotein receptor abundance in neurons. Single-cell RNA sequencing of the hypothalamus demonstrated that IDOL deletion altered gene expression linked to control of metabolism. Finally, we identify VLDLR rather than LDLR as the primary mediator of IDOL effects on energy balance. These studies identify a role for the neuronal IDOL-VLDLR pathway in metabolic homeostasis and diet-induced obesity

The Interaction of Relativization and Noun Incorporation in Southern Hokkaidō Ainu

This paper focuses on relativization in Southern Hokkaidō Ainu. Specifically, evidential expressions constitute the scope of this study since within this semantic domain a morphosyntactic layout reminiscent of internally-headed relative clauses (IHRCs) is found. Moreover, the structure of some evidential expressions suggests that what gives rise to an IHRC in those instances is classificatory noun incorporation (CNI). Following from past studies on Ainu, where IHRCs and CNI are never discussed, and with reference to cross-linguistic approaches to relativization and incorporation, this study addresses the interaction of these two processes in Southern Hokkaidō Ainu and suggests their reconsideration

Project #82: HFWH Vertical Treatment Zone

Problem Statement: Limited Emergency Department bed capacity and increased acuity resulted in increased left without completing service (LWCS) resulting in increased patient safety risk. Goal: Design a new patient throughput workflow to provide safe, timely and quality patient-centered care resulting in decreased LWSC, decreased arrival to provider times, decreased LOS of the discharged patient, and increased patient satisfaction.https://scholarlycommons.henryford.com/qualityexpo2023/1007/thumbnail.jp