The polarizability of the pion: no conflict between dispersion theory and chiral perturbation theory

Recent attempts to determine the pion polarizability by dispersion relations yield values that disagree with the predictions of chiral perturbation theory. These dispersion relations are based on specific forms for the absorptive part of the Compton amplitudes. The analytic properties of these forms are examined, and the strong enhancement of intermediate-meson contributions is shown to be connected with spurious singularities. If the basic requirements of dispersion relations are taken into account, the results of dispersion theory and effective field theory are not inconsistent.Comment: 30 pages, 8 figures, 6 table

High sensitivity phonon-mediated kinetic inductance detector with combined amplitude and phase read-out

The development of wide-area cryogenic light detectors with good energy resolution is one of the priorities of next generation bolometric experiments searching for rare interactions, as the simultaneous read-out of the light and heat signals enables background suppression through particle identification. Among the proposed technological approaches for the phonon sensor, the naturally-multiplexed Kinetic Inductance Detectors (KIDs) stand out for their excellent intrinsic energy resolution and reproducibility. To satisfy the large surface requirement (several cm$^2$) KIDs are deposited on an insulating substrate that converts the impinging photons into phonons. A fraction of phonons is absorbed by the KID, producing a signal proportional to the energy of the original photons. The potential of this technique was proved by the CALDER project, that reached a baseline resolution of 154$\pm$7 eV RMS by sampling a 2$\times$2 cm$^2$ Silicon substrate with 4 Aluminum KIDs. In this paper we present a prototype of Aluminum KID with improved geometry and quality factor. The design improvement, as well as the combined analysis of amplitude and phase signals, allowed to reach a baseline resolution of 82$\pm$4 eV by sampling the same substrate with a single Aluminum KID

New application of superconductors: high sensitivity cryogenic light detectors

In this paper we describe the current status of the CALDER project, which is developing ultra-sensitive light detectors based on superconductors for cryogenic applications. When we apply an AC current to a superconductor, the Cooper pairs oscillate and acquire kinetic inductance, that can be measured by inserting the superconductor in a LC circuit with high merit factor. Interactions in the superconductor can break the Cooper pairs, causing sizable variations in the kinetic inductance and, thus, in the response of the LC circuit. The continuous monitoring of the amplitude and frequency modulation allows to reconstruct the incident energy with excellent sensitivity. This concept is at the basis of Kinetic Inductance Detectors (KIDs), that are characterized by natural aptitude to multiplexed read-out (several sensors can be tuned to different resonant frequencies and coupled to the same line), resolution of few eV, stable behavior over a wide temperature range, and ease in fabrication. We present the results obtained by the CALDER collaboration with 2x2 cm2 substrates sampled by 1 or 4 Aluminum KIDs. We show that the performances of the first prototypes are already competitive with those of other commonly used light detectors, and we discuss the strategies for a further improvement

Characterization of the KID-Based Light Detectors of CALDER

The aim of the Cryogenic wide-Area Light Detectors with Excellent Resolution (CALDER) project is the development of light detectors with active area of $5\times5$ cm$^2$ and noise energy resolution smaller than 20 eV RMS, implementing phonon-mediated kinetic inductance detectors. The detectors are developed to improve the background suppression in large-mass bolometric experiments such as CUORE, via the double read-out of the light and the heat released by particles interacting in the bolometers. In this work, we present the characterization of the first light detectors developed by CALDER. We describe the analysis tools to evaluate the resonator parameters (resonant frequency and quality factors) taking into account simultaneously all the resonance distortions introduced by the read-out chain (as the feed-line impedance and its mismatch) and by the power stored in the resonator itself. We detail the method for the selection of the optimal point for the detector operation (maximizing the signal-to-noise ratio). Finally, we present the response of the detector to optical pulses in the energy range of 0-30 keV

Energy resolution and efficiency of phonon-mediated Kinetic Inductance Detectors for light detection

The development of sensitive cryogenic light detectors is of primary interest for bolometric experiments searching for rare events like dark matter interactions or neutrino-less double beta decay. Thanks to their good energy resolution and the natural multiplexed read-out, Kinetic Inductance Detectors (KIDs) are particularly suitable for this purpose. To efficiently couple KIDs-based light detectors to the large crystals used by the most advanced bolometric detectors, active surfaces of several cm$^2$ are needed. For this reason, we are developing phonon-mediated detectors. In this paper we present the results obtained with a prototype consisting of four 40 nm thick aluminum resonators patterned on a 2$\times$2 cm$^2$ silicon chip, and calibrated with optical pulses and X-rays. The detector features a noise resolution $\sigma_E=154\pm7$ eV and an (18$\pm$2)$\%$ efficiency.Comment: 5 pages, 5 figure

Characterization of biochars produced from pyrolysis of pelletized agricultural residues

Biochars produced from pelletized grape vine (GV) and sunflower husk (SFH) agricultural residues were studied by pyrolysis in a batch reactor at 400 and 500°C. Chemical and physical evolution of the biomass under pyrolysis conditions was determined and the products were characterized, including the main gaseous organic components. . Results showed a decrease in solid biochar yield with increasing temperature. Biochar is defined as a "porous carbonaceous solid" produced by thermochemical conversion of organic materials in an oxygen depleted atmosphere, which has physiochemical properties suitable for the safe and long-term storage of carbon in the environment and, potentially, soil improvement. The aim of this work is to improve the knowledge and acceptability of alternative use of the biochar gained from agro-forestry biomass residuals, such as grape vine and sunflower husks, by means of modern chemical and physical characterization tools

Sex-related differences in the association between metabolic syndrome and gallstone disease

Metabolic syndrome (MetS) and gallstone disease (GD) share common risk factors. Several epidemiological studies reported that subjects with Mets are more likely to have GD than those without and that cholecystectomy (CHO) may increase the risk of MetS. The aim of the study was to evaluate the association between MetS and GD in a large cohort of patients with metabolic risk factors in Italy. The study was performed in 620 consecutive outpatients referring to the University outpatients’ clinic for the management of cardiovascular risk factors. MetS were diagnosed according to the ATPIII Expert Panel modified criteria. GD was defined as gallstones documented by abdominal ultrasound (US) or previous cholecystectomy. The prevalence of GD was significantly higher in women than in men (22.3% vs. 13.1%, p = 0.003). Both prevalence of GD (17.1% vs. 8.4%, p = 0.015) and CHO (9.0% vs. 1.7%, p = 0.002) were significantly higher in males with MetS as compared to those without. By contrast, the prevalence of GD and of CHO was similar in women with and without MetS. After correction for confounders, MetS was an independent predictor of both GD (odds ratio (OR) 1.943, p = 0.048) and CHO (OR 5.075, p = 0.011) in men, but not in women. In conclusion, in this study, including western subjects with cardiometabolic risk factors, the association between GD, prior CHO and MetS were found in men, but not in women

New insights into the pathogenesis of non-alcoholic fatty liver disease: gut-derived lipopolysaccharides and oxidative stress

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. The intricate NAFLD pathogenesis is summarized by the multiple-hits hypothesis, which combines all the environmental and genetic factors that promote the development of NAFLD into a single scenario. Among these, bacterial lipopolysaccharides (LPS) are derived from the overgrowth of Gram-negative bacteria and translocated mainly as a consequence of enhanced intestinal permeability. Furthermore, oxidative stress is increased in NAFLD as a consequence of reactive oxygen species (ROS) overproduction and a shortage of endogenous antioxidant molecules, and it is promoted by the interaction between LPS and the Toll-like receptor 4 system. Interestingly, oxidative stress, which has previously been described as being overexpressed in cardiovascular disease, could represent the link between LPS and the increased cardiovascular risk in NAFLD subjects. To date, the only effective strategy for the treatment of NAFLD and non-alcoholic steatohepatitis (NASH) is the loss of at least 5% body weight in overweight and/or obese subjects. However, the dose-dependent effects of multispecies probiotic supplementation on the serum LPS level and cardiometabolic profile in obese postmenopausal women were demonstrated. In addition, many antibiotics have regulatory effects on intestinal microbiota and were able to reduce serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor alpha (TNF-α) in NASH animal models. Regarding the oxidant status, a Mediterranean diet has been reported to reduce oxidant stress, while vitamin E at high daily dosages induced the resolution of NASH in 36% of treated patients. Silymarin had the positive effect of reducing transaminase levels in NAFLD patients and long-term treatment may also decrease fibrosis and slow liver disease progression in NASH. Finally, the influence of nutraceuticals on gut microbiota and oxidant stress in NAFLD patients has not yet been well elucidated and there are insufficient data either to support or refuse their use in these subjects