Guillain-Barré syndrome caused by intravesical instillation of Bacillus Calmette-Guérin

Introduction – Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinat- ing polyneuropathy. In the vast majority of patients, 1-4 weeks before the onset of GBS-related symptoms, an event such as up- per respiratory tract or gastrointestinal tract infection, surgical intervention or vaccination is present. To the best of our knowledge, this is the first case of GBS that occurred after intravesical Bacillus Calmette-Guérin (BCG) therapy in the absence of tuberculosis or any other infection in the English literature. Case report – A 65-year-old male patient, who had no systemic disorders except hyperten- sion and coronary artery disease, underwent transurethral resection of a bladder tumour further to imaging studies investigating macro- scopic haematuria. A pathologic examination revealed a non-muscle-invasive high-grade (pT1HG) transitional cell carcinoma. Immedi- ately after the fourth cycle of intravesical BCG, which was administered 2 months after sur- gery, the patient experienced numbness and weakness in his lower and upper extremities, respectively. There were no signs or symp- toms related to an acute cranial pathology or infectious disease. Nerve conduction studies, which were carried out on the 7th day after the onset of the neurologic symptoms, revealed a demyelinating sensorimotor polyneuropathy with mild secondary axonal damage in upper and lower limbs with a sural sparing pattern. Conclusion – Without tuberculosis infection, GBS can occur secondary to increased im- mune response and antibodies triggered by intravesical BCG therapy. However, consider- ing the worldwide use of BCG vaccination and thousands of intravesical BCG therapies, this is a very rare adverse effect

Effects of the time of pregnant women's admission to the labor ward on the labor process and interventions

WOS: 000513094400001PubMed: 32027224Our aim to conduct the study was to investigate the effects of the time of pregnant women's admission to the labor ward on the labor process and interventions. This study is a two-group, prospective, analytical study. Groups were determined according to their cervical dilation levels. the data were collected using the Labor Process Form, and analyzed using the Statistical Package for the Social Sciences version. Within this context, the rates of amniotomy, induction with oxytocin, episiotomy, and cesarean section in the participants who presented to the hospital in the latent phase of labor were higher.Ege University Scientific Research Projects branchEge University [13-ASY0-010]This research supported by the Ege University Scientific Research Projects branch as 13-ASY0-010 project

Solid phase extractive preconcentration of trace metals using p-tert-butylcalix[4]arene-1,2-crown-4-anchored chloromethylated polymeric resin beads

5,11,17,23-Tetrakis(1,1-dimethylethyl)-25,26-dihydroxy-27,28-crown-4-calix[4]arene in the cone conformation was synthesized. This p-tertbutylcalix[4]arene-1,2-crown-4 compound was then anchored with Merrifield chloromethylated resin beads. The modified polymeric resin was characterized by H-1 NMR, FT-IR and elemental analysis and used successfully for the separation and preconcentration of Cu(II), Cd(II), Co(II), Ni(II) and Zn(II) prior to their determination by FAAS. Effective extraction conditions were optimized in both batch and column methods. The resin exhibits good separating ability with maximum between pH 6.0-7.0 for Cu(II), pH 6.0 for Cd(II), pH 5.0 for Co(II), pH 4.0-4.5 for Ni(II), and pH 4.5 for Zn(H). The elution studies were carried out with 0.5 mol L-1 HCL for Cu(II), Co(II) and Co(II), 1.0 mol L-1 HCl for Cd(II) and Zn(II). The sorption capacity, preconcentration factor and distribution coefficient of each metal ion were determined. The detection limits were 1.10, 1.25, 1.83, 1.68 and 2.01 mu g L-1 for Cu(II), Cd(II), Co(II), Ni(II) and Zn(II). The influence of several ions on the resin performance was also investigated. The validity of the proposed method was checked for these metal ions in NIST standard reference material 2709 (San Joaquin Soil) and 2711 (Montana Soil). (c) 2006 Elsevier B.V. All rights reserved

Practices of midwives working in delivery rooms for protection of perineum during intrapartum period and their feedback on these applications

WOS: 000566608800001PubMed: 32878505Introduction and hypothesis Perineal traumas occurring during labor are undesirable for both the midwives and the woman. Midwives and obstetricians could use different techniques to protect the perineum. Purpose the aim of this study was to determine the practices of midwives working in the delivery room to protect the perineum during the second stage of labor. Methods This is a prospective observational study regarding practices of midwifes for protection of perineum during intrapartum period. the study was conducted with a total of 20 midwives in a maternity unit of an training and research hospital. the data were collected through the forms prepared by the researchers. Findings the average age of the midwives was 34 +/- 8.77. the majority of midwives (n: 17, 85%) believed that the need for practices to protect the perineum during labor; 40% of them used perineal protection (hands on) technique to protect perineum and they preferred to perform routine episiotomy in all primiparas. Results and conclusions As a result of the study, it was observed that evidence-based practices was not applied sufficiently enough by the midwives although they were knowledgeable and believed that they are beneficial. Studies are needed for the obstacles to these practices to be identified and removed

Altitude training induced alterations in erythrocyte rheological properties: A controlled comparison study in rats

Altitude training is frequently used by athletes to improve sea-level performance. However, the objective benefits of altitude training are controversial. This study aimed to investigate the possible alterations in hemorheological parameters in response to altitude training. Sprague Dawley rats, were divided into 6 groups: live low-train low (LLTL), live high-train high (LHTH), live high-train low (LHTL) and their controls live high and low (LHALC), live high (LHC), live low (LLC). LHC and LHTH groups were exposed to hypoxia (15% O2, altitudes of 3000 m), 4 weeks. LHALC and LHTL were exposed to 12 hours hypoxia/normoxia per day, 4 weeks. Hypoxia was maintained by a hypoxic tent. The training protocol corresponded to 60-70% of maximal exercise capacity. Rats of training groups ran on treadmill for 20-30 min/day, 4 days/week, 4 weeks. Erythrocyte deformability of LHC group was increased compared to LHALC and LLC. Deformability of LHTH group was higher than LHALC and LLTL groups. No statistically significant alteration in erythrocyte aggregation parameters was observed. There were no significant relationships between RBC deformability and exercise performance. The results of this study show that, living (LHC) and training at altitude (LHTH) seems more advantageous in hemorheological point of view. © 2014 - IOS Press and the authors. All rights reserved

Does pandemic change the ocrelizumab therapy approach? Yes. : Single center ocrelizumab experience = Módosult-e a pandémia alatt az ocrelizumabkezelés? Igen. – Egy központú tapasztalat ocrelizumabkezeléssel

Background and purpose – We know that treatment algorithms have changed in Multiple Sclerosis (MS) practice during the pandemic. In this study, we aimed to investigate whether there was a change in the patient population for ocrelizumab (OCR) treatment during the pandemic period, the treatment compliance of the patients, and the course of the Coronavirus Disease-19 (COVID-19) disease in the patients who received OCR. Methods – Our study was designed as a survey study. A questionnaire was sent to the patients assessing whether they had COVID-19 infection, whether they received treatments regularly before and after the pandemic, vaccination status and duration of OCR treatment. Demographic characteristics of the patients, treatments they used before, MS type, Expanded Disability Status Scale (EDSS) scores were determined from the database. Each group of OCR started before pandemic and OCR started after pandemic were compared. Results – We included into the study 86 patients who started OCR before pandemic period and 75 patients who started OCR after the pandemic. Demographic features were similar. EDSS scores were higher in the group that started OCR treatment before the pandemic (p<0.0001). The patients who started OCR treatment before the pandemic had more disruptions than which started during the pandemic (p<0.0001). No correlation was found between the duration of OCR treatment and COVID-19 infection (p=0.940). We observed that the patients who had severe COVID-19 infection had received OCR therapy for a longer period. Conclusion – This retrospective study concluded that the OCR treatment approach in our center had changed during the pandemic period. OCR therapy was started in patients with less disability. The possible reasons for this situation include the proven relationship between high EDSS and serious COVID-19 infection, and that the patients who have higher EDSS score had troubles in reaching health institutions during the pandemic. The result that patients with severe COVID-19 infection received OCR treatment for a longer period necessitates more evidence-based research to investigate the relationship between treatment duration and disease severity. = Háttér és cél – Tudjuk, hogy a sclerosis multiplex (SM) kezelési algoritmusai megváltoztak a pandémia alatt. Vizsgálatunk célja az volt, hogy elemezzük, megváltozott-e az ocrelizumabkezelésben (OCR) részesült betegpopuláció a pandémia alatt, milyen volt a betegek terápiás adherenciája, és milyen volt a Coronavirus Disease-19 (Covid-19) betegség lefolyása az OCR-kezelésben részesült betegek körében. Módszerek – Kérdôíves vizsgálatot végeztünk. Kérdôívet küldtünk betegeinknek, és megkérdeztük, volt-e Covid-19 betegségük, részesültek-e rendszeres kezelésben a pan dé - mia elôtt és után, milyen a vakcinációs státuszuk, és milyen régóta részesülnek OCR-kezelésben. A betegek demográfiai jellemzôit, korábbi gyógyszerelésük adatait, SM-betegségük típusát, Expanded Disability Status Scale- (EDSS-) pontszámukat adatbázisunkból gyûjtöttük ki. Összehasonlítottuk azokat a betegcsoportokat, akik OCRkezelése a pandémia elôtt, illetve utána indult. Eredmények – Nyolcvanhat olyan beteget vontunk be a vizsgálatba, akinek OCR-kezelése a pandémia elôtt indult, és 75 olyan beteget, akinek utána. A két csoport demo - grá fiai jellemzôi megegyeztek. A pandémia elôtt indult OCR-kezelésben részesültek EDSS-pontszámai magasabbak voltak (p < 0,0001), és több megszakítás volt a te - rápiájukban (p < 0,0001), mint azoknak, akik kezelése a pandémia indulása után kezdôdött. Nem találtunk összefüggést az OCR-kezelés idôtartama és a SARS-CoV2-fertôzés bekövetkezte között (p = 0,940). Megfigyelésünk szerint azok a betegek, akik súlyos Covid19 betegségben szenvedtek, hosszabb ideig részesültek OCR-kezelésben. Következtetés – Retrospektív vizsgálatunk eredménye szerint központunkban a pandémia alatt módosult az OCR-kezelés megközelítése. Enyhébb betegséggel küzdô betegeknél indult OCR-kezelés. E szituáció lehetséges okai közé tartozik a magas EDSS-pontszám és a súlyos Covid19 betegség közötti bizonyított kapcsolat, valamint az, hogy a magasabb EDSS-pontszámmal bíró betegek nehezebben érték el az egészségügyi intézményeket a járvány alatt. Eredményük, miszerint a súlyos Covid-19 betegségben szenvedôk hosszabb ideig részesültek OCRkezelésben, arra hívja fel a figyelmet, hogy több bizonyíték alapú kutatásra van szükség a kezelés idôtartama és a betegségsúlyosság közötti összefüggés tisztázása érdekében

The effect of demographic and disease variables on Schneiderian membrane thickness and appearance

Objectives. The purpose of this study was to evaluate the prevalence of sinus mucosal thickening (MT) and mucosal appearance (MA) in a patient population as detected with cone beam computed tomography (CBCT) and to determine the effects of various disease and demographic factors on MT and MA

Investigation of the effects of continuous theta burst transcranial magnetic stimulation in patients with migraine

Objective: Repetitive transcranial magnetic stimulation (rTMS) allows the non-invasive investigation of synaptic plasticity. Theta-burst stimulation (TBS) is a modified form of rTMS that induces synaptic plasticity. Our objective was to evaluate cortical excitability using paired-pulse transcranial magnetic stimulation (ppTMS) before and after continuous TBS (cTBS) in healthy controls and patients with migraine

AR-A014418 as a glycogen synthase kinase-3 inhibitor: Anti-apoptotic and therapeutic potential in experimental spinal cord injury

Objectives: We aimed to investigate the effects of AR-A014418, a strong inhibitor specific to GSK-3beta, on neuronal apoptosis and neuroprotection in the traumatic SCI model