Generalized Spike-Waves, Multiple Loci, and Clinical Course in Children with EEG Features of Benign Epilepsy of Childhood with Centrotemporal Spikes

In 41 patients with EEG features of benign epilepsy of childhood with centrotemporal spikes (BECCT), we noted associated generalized spike-wave discharges (GSWD) in 14.6% and multiple independent sharp wave foci in 9.8%. The presence or absence of these EEG features was not predictive of the clinical course. The high incidence of GSWD in children with BECCT suggests a possible relation in the expression of these two EEG traits.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66418/1/j.1528-1157.1992.tb01764.x.pd

T-HITL Effectively Addresses Problematic Associations in Image Generation and Maintains Overall Visual Quality

Generative AI image models may inadvertently generate problematic representations of people. Past research has noted that millions of users engage daily across the world with these models and that the models, including through problematic representations of people, have the potential to compound and accelerate real-world discrimination and other harms (Bianchi et al, 2023). In this paper, we focus on addressing the generation of problematic associations between demographic groups and semantic concepts that may reflect and reinforce negative narratives embedded in social data. Building on sociological literature (Blumer, 1958) and mapping representations to model behaviors, we have developed a taxonomy to study problematic associations in image generation models. We explore the effectiveness of fine tuning at the model level as a method to address these associations, identifying a potential reduction in visual quality as a limitation of traditional fine tuning. We also propose a new methodology with twice-human-in-the-loop (T-HITL) that promises improvements in both reducing problematic associations and also maintaining visual quality. We demonstrate the effectiveness of T-HITL by providing evidence of three problematic associations addressed by T-HITL at the model level. Our contributions to scholarship are two-fold. By defining problematic associations in the context of machine learning models and generative AI, we introduce a conceptual and technical taxonomy for addressing some of these associations. Finally, we provide a method, T-HITL, that addresses these associations and simultaneously maintains visual quality of image model generations. This mitigation need not be a tradeoff, but rather an enhancement.Comment: 11 pages, 8 figure

Why whole body gestational donation must be rejected: a response to Smajdor

Anna Smajdor’s proposal of whole body gestational donation (WBGD) states that female patients diagnosed as brain-dead should be considered for use as gestational donors. In this response, Smajdor’s proposal is rejected on four different accounts: (a) the debated acceptability of surrogacy despite women's autonomy, (b) the harm to dead women ́s interests, (c) the interests of the descendants, and (d) the symbolic value of the body and interests of relatives. The first part argues that WBGD rests on a particular conception of the instrumentalization of bodies that cannot be circumvented simply by the patient’s consent and relinquished autonomy. The second part argues the importance of avoiding any harm to dead women’s interests. The third part identifies the importance of the interest of the foetus in the light of Procreative-Beneficence principle that Smajdor overlooks. And finally, the fourth part considers the symbolic value of the human body and the interest of relatives. The main goal of this commentary is not to show that WBGD cannot be implemented; rather, it is to show that there are not any good arguments in favour of doing so.Aníbal M. Astobiza gratefully acknowledges the support provided by the project INEDyTO II: bioética y prácticas relacionadas con el final de la vida (PID2020-118729RB-I00). Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature

Réponse à un appel d'offre. Les lignes suburbaines de l'agglomération rennaise

Les appels d'offre sont des étapes essentielles dans la vie d'une entreprise de transport de voyageurs. Ils remettent, en effet, périodiquement en jeu une part importante des activités de l'entreprise, et dégagent de ce fait des enjeux importants. Le présent rapport détaille, dans sa globalité, une procédure d'appel d'offre du point de vue de l'entreprise : les impératifs de la procédure, l'élaboration d'une stratégie de réponse, les étapes nécessaires à la conception de la réponse, la négociation du nouveau contrat puis le travail indispensable à l'exploitation concrète du marché remporté. Il traite également des enjeux dégagés par une telle procédure pour l'entreprise, ainsi que des contraintes dont elle ne peut se défaire.transports en commun, appel d'offre, entreprise interurbaine, lignes suburbaines, graphiquage, habillage, roulements, Rennes (France)

Laser-induced rotation and cooling of a trapped microgyroscope in vacuum

This work was supported by the UK Engineering and Physical Sciences Research Council (EPSRC grant numbers: EP/J01771X/1 and EP/G061688/1)Quantum state preparation of mesoscopic objects is a powerful playground for the elucidation of many physical principles. The field of cavity optomechanics aims to create these states through laser cooling and by minimizing state decoherence. Here we demonstrate simultaneous optical trapping and rotation of a birefringent microparticle in vacuum using a circularly polarized trapping laser beam—a microgyroscope. We show stable rotation rates up to 5 MHz. Coupling between the rotational and translational degrees of freedom of the trapped microgyroscope leads to the observation of positional stabilization in effect cooling the particle to 40 K. We attribute this cooling to the interaction between the gyroscopic directional stabilization and the optical trapping field.Publisher PDFPeer reviewe