Religious education in Italian public schools: what room for Islam?

SOMMARIO: 1. Introduction - 2. Religious education in Italian public schools: general framework - 3. Religious education in public schools: the situation of Islam - 3.1. Some data about the Islamic presence in Italy - 3.2. Religious education and Islam - 4. The religious education in plural Italy: challenges and gaps - 5 - Muslims at school and Religious Education: which solutions? - 5.1 Alternative 1: private schools - 5.2 Alternative 1-bis: Homeschooling - 5.3 Alternative 2: introduction of lessons about religion - 5.4 Alternative 3: Muslim pupils and their participation in the Catholic religion lessons - 6. Conclusions: challenges, problems and future perspectives

Российская интеллигенция: блеск и нищета духа

Hairy and enhancer of split 1, one of the main downstream effectors in Notch signaling, is a transcriptional repressor of the basic helix-loop-helix (bHLH) family. Using nuclear magnetic resonance methods, we have determined the structure and dynamics of a recombinant protein, H1H, which includes an N-terminal segment, b1, containing functionally important phosphorylation sites, the basic region b2, required for binding to DNA, and the HLH domain. We show that a proline residue in the sequence divides the protein in two parts, a flexible and disordered N-terminal region including b1 and a structured, mainly helical region comprising b2 and the HLH domain. Binding of H1H to a double strand DNA oligonucleotide was monitored through the chemical shift perturbation of backbone amide resonances, and showed that the interaction surface involves not only the b2 segment but also several residues in the b1 and HLH regions

Urinary EpCAM in urothelial bladder cancer patients: characterisation and evaluation of biomarker potential

Background: Epithelial cell adhesion molecule is overexpressed in bladder tumours and released from bladder cancer cells in vitro. We test the hypotheses that urinary EpCAM could act as a biomarker for primary bladder cancer detection and risk stratification. Methods: Epithelial cell adhesion molecule was measured by ELISA in urine from 607 patients with primary bladder tumours and in urine from 53 non-cancer controls. Mann–Whitney tests and ROC analyses were used to determine statistical significance and discrimination between non-cancer controls and different stages and grades of disease. Multivariable modelling and Kaplan–Meier analyses were used to determine prognostic significance. The structure of urinary EpCAM was investigated by western blotting and mass spectrometry. Results: Urinary EpCAM levels increase with stage and grade of bladder cancer. Alongside grade and stage, elevated urinary EpCAM is an independent indicator of poor prognosis with a hazard ratio of 1.76 for bladder cancer-specific mortality. The soluble form of EpCAM in urine is the extracellular domain generated by cleavage between ala243 and gly244. Further studies are required to define the influence of other urinary tract malignancies and benign urological conditions on urinary EpCAM. Conclusion: The extracellular domain of EpCAM is shed into urine by bladder tumours. Urinary EpCAM is a strong indicator of bladder cancer-specific survival, and may be useful within a multi-marker panel for disease detection or as a stand-alone marker to prioritise the investigation and treatment of patients. The mechanisms and effects of EpCAM cleavage in bladder cancer are worthy of further investigation, and may identify novel therapeutic targets

Controllo laterale e longitudinale di un Boeing 747

Lo scopo di questa tesina è quello di utilizzare i risultati della teoria dei controlli automatici per la risoluzione di un problema pratico: il controllo di un Boeing 747. Per ottenere ciò, si utilizzerà uno schema empirico adattabile a qualsiasi sistema da controllare: inizialmente si porrà attenzione alla descrizione del modello fisico, successivamente si tradurrà quanto appreso in un modello matematico, dove effettuare le considerazioni atte all'identificazione del controllore utilizzato per pilotare il sistema. In ultima fase si effettuerà la simulazione di sistema, giovando del software Matlab, in particolare dell'interfaccia SISOtoo

"Dispargen"-Therapie des Fleckfiebers

n/

La tutela delle diversità alimentari religiose in Spagna

1nonenoneCoglievina,