44 research outputs found
App: RxBurnTracker
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Prescribed burn equipment
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Prescribed burning: Spotfires and escapes
The Oklahoma Cooperative Extension Service periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311
Angular Momentum and the Formation of Stars and Black Holes
The formation of compact objects like stars and black holes is strongly
constrained by the requirement that nearly all of the initial angular momentum
of the diffuse material from which they form must be removed or redistributed
during the formation process. The mechanisms that may be involved and their
implications are discussed for (1) low-mass stars, most of which probably form
in binary or multiple systems; (2) massive stars, which typically form in
clusters; and (3) supermassive black holes that form in galactic nuclei. It is
suggested that in all cases, gravitational interactions with other stars or
mass concentrations in a forming system play an important role in
redistributing angular momentum and thereby enabling the formation of a compact
object. If this is true, the formation of stars and black holes must be a more
complex, dynamic, and chaotic process than in standard models. The
gravitational interactions that redistribute angular momentum tend to couple
the mass of a forming object to the mass of the system, and this may have
important implications for mass ratios in binaries, the upper stellar IMF in
clusters, and the masses of supermassive black holes in galaxies.Comment: Accepted by Reports on Progress in Physic
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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease
Abstract Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs) in HD. We reconstructed a genome‐scale model for the target genes of 718 transcription factors (TFs) in the mouse striatum by integrating a model of genomic binding sites with transcriptome profiling of striatal tissue from HD mouse models. We identified 48 differentially expressed TF‐target gene modules associated with age‐ and CAG repeat length‐dependent gene expression changes in Htt CAG knock‐in mouse striatum and replicated many of these associations in independent transcriptomic and proteomic datasets. Thirteen of 48 of these predicted TF‐target gene modules were also differentially expressed in striatal tissue from human disease. We experimentally validated a specific model prediction that SMAD3 regulates HD‐related gene expression changes using chromatin immunoprecipitation and deep sequencing (ChIP‐seq) of mouse striatum. We found CAG repeat length‐dependent changes in the genomic occupancy of SMAD3 and confirmed our model's prediction that many SMAD3 target genes are downregulated early in HD
DataSHIELD – new directions and dimensions
In disciplines such as biomedicine and social sciences, sharing and combining sensitive individual-level data is often prohibited by ethical-legal or governance constraints and other barriers such as the control of intellectual property or the huge sample sizes. DataSHIELD (Data Aggregation Through Anonymous Summary-statistics from Harmonised Individual-levEL Databases) is a distributed approach that allows the analysis of sensitive individual-level data from one study, and the co-analysis of such data from several studies simultaneously without physically pooling them or disclosing any data.
Following initial proof of principle, a stable DataSHIELD platform has now been implemented in a number of epidemiological consortia. This paper reports three new applications of DataSHIELD including application to post-publication sensitive data analysis, text data analysis and privacy protected data visualisation. Expansion of DataSHIELD analytic functionality and application to additional data types demonstrate the broad applications of the software beyond biomedical sciences
Clustered Coding Variants in the Glutamate Receptor Complexes of Individuals with Schizophrenia and Bipolar Disorder
Current models of schizophrenia and bipolar disorder implicate multiple genes,
however their biological relationships remain elusive. To test the genetic role
of glutamate receptors and their interacting scaffold proteins, the exons of ten
glutamatergic ‘hub’ genes in 1304 individuals were re-sequenced in
case and control samples. No significant difference in the overall number of
non-synonymous single nucleotide polymorphisms (nsSNPs) was observed between
cases and controls. However, cluster analysis of nsSNPs identified two exons
encoding the cysteine-rich domain and first transmembrane helix of GRM1 as a
risk locus with five mutations highly enriched within these domains. A new
splice variant lacking the transmembrane GPCR domain of GRM1 was discovered in
the human brain and the GRM1 mutation cluster could perturb the regulation of
this variant. The predicted effect on individuals harbouring multiple mutations
distributed in their ten hub genes was also examined. Diseased individuals
possessed an increased load of deleteriousness from multiple concurrent rare and
common coding variants. Together, these data suggest a disease model in which
the interplay of compound genetic coding variants, distributed among glutamate
receptors and their interacting proteins, contribute to the pathogenesis of
schizophrenia and bipolar disorders
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead