Tinea Capitis in Adults. A Diagnosis to Consider?

A tinea capitis, uma infecção por fungos dermatófitos do couro cabeludo, é uma patologia rara no adulto, mesmo em áreas geográficas onde a doença é prevalente. Nestes casos está muitas vezes, mas não exclusivamente, associada a imunodepressão e habitualmente surge por exposição ao agente infeccioso em contactantes próximos. São fundamentais uma história clínica e um exame objectivo minuciosos que permitam equacionar a tinha do couro cabeludo como hipótese diagnóstica e proceder à colheita de amostras para exame micológico. Esta metodologia pode evitar a realização de exames complementares exaustivos ou a prescrição de tratamentos inadequados. Os autores descrevem três casos de tinea capitis em mulheres adultas – dois casos de infecção por Microsporum audouinii e um caso por Trichophyton soudanense. É apresentado o registo iconográfico dos casos e é efectuada breve revisão da literatura

Optimization of oil recovery from Japonica luna rice bran by supercritical carbon dioxide applying design of experiments: characterization of the oil and mass transfer modeling

This study presents an optimization strategy for recovery of oil from Japonica Luna rice bran using supercritical carbon dioxide (scCO2), based on design of experiments (DoE). Initially, a 24−1 two level fractional factorial design (FFD) was used, and pressure, temperature, and scCO2 flow rate were determined as the significant variables; while the yield, total flavonoids content (TFC), and total polyphenols content (TPC) were the response functions used to analyze the quality of the extracts recovered. Subsequently, central composite design (CCD) was applied to examine the effects of the significant variables on the responses and create quadratic surfaces that optimize the latter. The following values of pressure = 34.35 MPa, temperature = 339.5 K, and scCO2 flow rate = 1.8 × 10−3 kg/min were found to simultaneously optimize the yield (6.83%), TPC (61.28 μmol GAE/g ext), and TFC (1696.8 μmol EC/g ext). The fatty acid profile of the oils was characterized by GC-FID. It was demonstrated that the acids in largest quantities are C16:0 (15–16%), C18:1 (41%), and C18:2 (38–39%). Finally, three mass transfer models were applied to determine the mass transfer coefficients and assess the cumulative extraction curves, with an AAD% of 4.16, for the best model.info:eu-repo/semantics/publishedVersio

Cryopreservation of coffee seeds: a simplified method.

Coffee seeds are sensitive to desiccation and to storage. Advances in the technique of cryopreservation of these seeds have been achieved in recent years, and the aim of this study was to evaluate Coffea arabica seeds cryopreserved through direct immersion in liquid nitrogen after rapid and slow drying. Seeds of the cultivars ?Arara?, ?Catiguá?, ?Catuaí Amarelo? and ?Mundo Novo? underwent rapid and slow drying to 20% moisture content (dry basis); they were then immersed in liquid nitrogen for 24 hours and after that, reheated in a water bath. C. arabica seeds have better physiological quality after slow drying, but rapid drying is better for cryopreservation of these seeds. The seeds of the cultivars investigated have different levels of tolerance, but all can be cryopreserved; ?Catuaí Amarelo? is the most tolerant and ?Arara? the most sensitive to cryopreservation, regardless of the drying speed. The activity of the enzymes catalase, peroxidase and esterase increased after drying and after cryopreservation. Rapid drying in silica gel to 20% moisture content, followed by direct immersion in liquid nitrogen, allows cryopreservation of coffee seeds in a fast, simple and economical manner

Dynamic modelling to describe the effect of plant extracts and customised starter culture on Staphylococcus aureus survival in goat's raw milk soft cheese

This study characterises the effect of a customised starter culture (CSC) and plant extracts (lemon balm, sage, and spearmint) on Staphylococcus aureus (SA) and lactic acid bacteria (LAB) kinetics in goat’s raw milk soft cheeses. Raw milk cheeses were produced with and without the CSC and plant extracts, and analysed for pH, SA, and LAB counts throughout ripening. The pH change over maturation was described by an empirical decay function. To assess the effect of each bio-preservative on SA, dynamic Bigelow-type models were adjusted, while their effect on LAB was evaluated by classical Huang models and dynamic Huang–Cardinal models. The models showed that the bio-preservatives decreased the time necessary for a one-log reduction but generally affected the cheese pH drop and SA decay rates (logDref=0.621–1.190 days; controls: 0.796–0.996 days). Spearmint and sage extracts affected the LAB specific growth rate (0.503 and 1.749 ln CFU/g day−1; corresponding controls: 1.421 and 0.806 ln CFU/g day−1), while lemon balm showed no impact (p > 0.05). The Huang–Cardinal models uncovered different optimum specific growth rates of indigenous LAB (1.560–1.705 ln CFU/g day−1) and LAB of cheeses with CSC (0.979–1.198 ln CFU/g day−1). The models produced validate the potential of the tested bio-preservatives to reduce SA, while identifying the impact of such strategies on the fermentation process.The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2020). They are also grateful to the EU PRIMA program and FCT for funding the ArtiSaneFood project (PRIMA/0001/2018). This study was supported by FCT under the scope of the strategic funding of the UIDB/04469/2020 unit and the BioTecNorte operation (NORTE-01-0145-FEDER-000004) funded by the European Regional Development Fund under the scope of Norte2020—Programa Operacional Regional do Norte. B.N. Silva acknowledges the financial support provided by FCT through the Ph.D. grant SFRH/BD/137801/2018.info:eu-repo/semantics/publishedVersio

μ-Oxido-bis­[chlorido(4,4′-di-tert-butyl-2,2′-bipyridine-κ2 N,N′)dioxido­molybdenum(VI)] 0.2-hydrate

The title hydrate, [Mo2Cl2O5(C18H24N2)2]·0.2H2O, has been isolated as the oxidation product of [Mo(η3-C3H5)Cl(CO)2(di-t-Bu-bipy)] (where di-t-Bu-bipy is 4,4′-di-tert-butyl-2,2′-bipyridine). A μ-oxide ligand bridges two similar MoCl(di-t-Bu-bipy)O2 units, having the terminal oxide ligands mutually cis, and the chloride and μ-oxide trans to each other. In the binuclear complex, the coordination geometries of the metal atoms can be described as highly distorted octa­hedra. Individual complexes co-crystallize with a partially occupied water mol­ecule of crystallization (occupancy factor = 0.20; H atoms not located), with the crystal packing being mediated by the need to effectively fill the available space. A number of weak C—H⋯O and C—H⋯Cl inter­actions are present

Leprosy and Kaposi Sarcoma Presenting as an Immune Reconstitution Inflammatory Syndrome in a Patient with AIDS

The simultaneous presence of infectious organisms within cutaneous lesions of Kaposi sarcoma in persons with AIDS has been demonstrated. We describe a patient with concurrent leprosy and Kaposi sarcoma presenting as an immune reconstitution inflammatory syndrome in the setting of AIDS