529 research outputs found
LMO2 and IL2RG synergize in thymocytes to mimic the evolution of SCID-X1 gene therapy-associated T-cell leukaemia
The SCID-X1 disease occurs in males that lack a functional X-linked gene encoding the interleukin 2 receptor subunit gamma (IL2RG) and thus are immuno-deficient (reviewed in Rochman et al.). Gene therapy has been a success in curing SCID-X1 in patients receiving autologous CD34+-bone marrow cells infected with retroviruses expressing IL2RG. This treatment protocol has, however, produced adverse T-cell effects where clonal T-cell leukaemias arose, and four have insertional mutagenesis of the T-cell oncogene LMO2. LMO2 is a T-cell oncogene first discovered via chromosomal translocations in T-cell acute leukaemia (T-ALL) (reviewed in Chambers and Rabbitts). It is unclear if the T-cell neoplasias in the SCID-X1 patients are simply due to insertional activation of the LMO2 gene or reflect synergy between LMO2 and IL2RG. Further, the recurrent involvement of LMO2 in SCID-X1 leukaemias is puzzling as other T-cell oncogenes (for example, TAL1/SCL, HOX11 and LYL1) might equally have been targets. This suggests that specific properties of LMO2 per se are required in these adverse events. The oncogenic potential of IL2RG itself also remains controversial. Although it causes T-cell lymphomas in mice transplanted with virally transduced haematopoetic stem cells, other studies have indicated that IL2RG is not an oncogene. Here we provide evidence that synergy is required between LMO2 and IL2RG proteins specifically in the T-cell lineage to elicit neoplasias and that additional mutations are required such as Notch1 mutations like those in human T-ALL
Kinetic models of heterogeneous dissipation
We suggest kinetic models of dissipation for an ensemble of interacting
oriented particles, for example, moving magnetized particles. This is achieved
by introducing a double bracket dissipation in kinetic equations using an
oriented Poisson bracket, and employing the moment method to derive continuum
equations for magnetization and density evolution. We show how our continuum
equations generalize the Debye-Hueckel equations for attracting round
particles, and Landau-Lifshitz-Gilbert equations for spin waves in magnetized
media. We also show formation of singular solutions that are clumps of aligned
particles (orientons) starting from random initial conditions. Finally, we
extend our theory to the dissipative motion of self-interacting curves.Comment: 28 pages, 2 figures. Submitted to J. Phys.
An insight into the suspected HbA2' cases detected by high performance liquid chromatography in Pakistan
Background:Hemoglobin A2\u27 (delta 16 Gly Arg) is globally the commonest delta chain variant of HbA2. It is clinically and hematologically silent but its sole importance lies in the underestimation of HbA2 quantity during the workup of beta-thalassaemia trait. High performance liquid chromatography (HPLC) identifies it as a small S-window peak with a mean retention time of 4.59 0.03 minutes. This study aims at describing the frequency of detection of HbA2\u27 by HPLC in Pakistan and its confirmation at a molecular level. Potential HbA2\u27 cases were identified by a retrospective review of 10186 HPLC chromatograms in year 2006. Prospective samples were collected for polymerase chain reaction (PCR) amplification, restriction digestion and nucleotide sequencing.
Findings:
One hundred and ninety two potential cases (1.89%) of HbA2\u27 were detected on HPLC, having mean retention time of 4.59 0.05 minutes. Sixty four (0.6%) new cases were suspected of having co-existing beta-thalassaemia trait when the quantity of S-window peaks was taken into account. Thirteen samples with presumed HbA2\u27 on HPLC were subjected to molecular analysis and the said mutation (delta 16 GGC CGC) was not detected in any sample.
Conclusion:
It is concluded that diagnosis of HbA2\u27 on HPLC alone is not justified, as evidence of the presence of this delta chain variant in Pakistani population is yet to be proven. Such small S-window peaks should be either disregarded or confirmed at molecular level, and only then should influence the diagnosis of beta-thalassaemia trait. Further studies are required to determine the true nature of these peaks
Longitudinal Spin Transfer to and Hyperons in Polarized Proton-Proton Collisions at = 200 GeV
The longitudinal spin transfer, , from high energy polarized protons
to and hyperons has been measured for the first time
in proton-proton collisions at with the STAR
detector at RHIC. The measurements cover pseudorapidity, , in the range
and transverse momenta, , up to . The longitudinal spin transfer is found to be for inclusive
and for
inclusive hyperons with and . The dependence on and is presented.Comment: 5 pages, 4 figure
An Experimental Exploration of the QCD Phase Diagram: The Search for the Critical Point and the Onset of De-confinement
The QCD phase diagram lies at the heart of what the RHIC Physics Program is
all about. While RHIC has been operating very successfully at or close to its
maximum energy for almost a decade, it has become clear that this collider can
also be operated at lower energies down to 5 GeV without extensive upgrades. An
exploration of the full region of beam energies available at the RHIC facility
is imperative. The STAR detector, due to its large uniform acceptance and
excellent particle identification capabilities, is uniquely positioned to carry
out this program in depth and detail. The first exploratory beam energy scan
(BES) run at RHIC took place in 2010 (Run 10), since several STAR upgrades,
most importantly a full barrel Time of Flight detector, are now completed which
add new capabilities important for the interesting physics at BES energies. In
this document we discuss current proposed measurements, with estimations of the
accuracy of the measurements given an assumed event count at each beam energy.Comment: 59 pages, 78 figure
Measurements of Dihadron Correlations Relative to the Event Plane in Au+Au Collisions at GeV
Dihadron azimuthal correlations containing a high transverse momentum (\pt)
trigger particle are sensitive to the properties of the nuclear medium created
at RHIC through the strong interactions occurring between the traversing parton
and the medium, i.e. jet-quenching. Previous measurements revealed a strong
modification to dihadron azimuthal correlations in Au+Au collisions with
respect to \pp\ and \dAu\ collisions. The modification increases with the
collision centrality, suggesting a path-length dependence to the jet-quenching
effect. This paper reports STAR measurements of dihadron azimuthal correlations
in mid-central (20-60\%) Au+Au collisions at \snn=200~GeV as a function of
the trigger particle's azimuthal angle relative to the event plane,
\phis=|\phit-\psiEP|. The azimuthal correlation is studied as a function of
both the trigger and associated particle \pt. The subtractions of the
combinatorial background and anisotropic flow, assuming Zero Yield At Minimum
(\zyam), are described. The away-side correlation is strongly modified, and the
modification varies with \phis, which is expected to be related to the
path-length that the away-side parton traverses. The pseudo-rapidity (\deta)
dependence of the near-side correlation, sensitive to long range \deta
correlations (the ridge), is also investigated. The ridge and jet-like
components of the near-side correlation are studied as a function of \phis.
The ridge appears to drop with increasing \phis while the jet-like component
remains approximately constant. ...Comment: 50 pages, 39 figures, 6 table
Studies of di-jet survival and surface emission bias in Au+Au collisions via angular correlations with respect to back-to-back leading hadrons
We report first results from an analysis based on a new multi-hadron
correlation technique, exploring jet-medium interactions and di-jet surface
emission bias at RHIC. Pairs of back-to-back high transverse momentum hadrons
are used for triggers to study associated hadron distributions. In contrast
with two- and three-particle correlations with a single trigger with similar
kinematic selections, the associated hadron distribution of both trigger sides
reveals no modification in either relative pseudo-rapidity or relative
azimuthal angle from d+Au to central Au+Au collisions. We determine associated
hadron yields and spectra as well as production rates for such correlated
back-to-back triggers to gain additional insights on medium properties.Comment: By the STAR Collaboration. 6 pages, 2 figure
System size and energy dependence of near-side di-hadron correlations
Two-particle azimuthal () and pseudorapidity ()
correlations using a trigger particle with large transverse momentum () in
+Au, Cu+Cu and Au+Au collisions at =\xspace 62.4 GeV and
200~GeV from the STAR experiment at RHIC are presented. The \ns correlation is
separated into a jet-like component, narrow in both and
, and the ridge, narrow in but broad in .
Both components are studied as a function of collision centrality, and the
jet-like correlation is studied as a function of the trigger and associated
. The behavior of the jet-like component is remarkably consistent for
different collision systems, suggesting it is produced by fragmentation. The
width of the jet-like correlation is found to increase with the system size.
The ridge, previously observed in Au+Au collisions at = 200
GeV, is also found in Cu+Cu collisions and in collisions at
=\xspace 62.4 GeV, but is found to be substantially smaller at
=\xspace 62.4 GeV than at = 200 GeV for the
same average number of participants ().
Measurements of the ridge are compared to models.Comment: 17 pages, 14 figures, submitted to Phys. Rev.
Observation of the antimatter helium-4 nucleus
High-energy nuclear collisions create an energy density similar to that of
the universe microseconds after the Big Bang, and in both cases, matter and
antimatter are formed with comparable abundance. However, the relatively
short-lived expansion in nuclear collisions allows antimatter to decouple
quickly from matter, and avoid annihilation. Thus, a high energy accelerator of
heavy nuclei is an efficient means of producing and studying antimatter. The
antimatter helium-4 nucleus (), also known as the anti-{\alpha}
(), consists of two antiprotons and two antineutrons (baryon
number B=-4). It has not been observed previously, although the {\alpha}
particle was identified a century ago by Rutherford and is present in cosmic
radiation at the 10% level. Antimatter nuclei with B < -1 have been observed
only as rare products of interactions at particle accelerators, where the rate
of antinucleus production in high-energy collisions decreases by about 1000
with each additional antinucleon. We present the observation of the antimatter
helium-4 nucleus, the heaviest observed antinucleus. In total 18
counts were detected at the STAR experiment at RHIC in 10 recorded Au+Au
collisions at center-of-mass energies of 200 GeV and 62 GeV per nucleon-nucleon
pair. The yield is consistent with expectations from thermodynamic and
coalescent nucleosynthesis models, which has implications beyond nuclear
physics.Comment: 19 pages, 4 figures. Submitted to Nature. Under media embarg
Inclusive pi^0, eta, and direct photon production at high transverse momentum in p+p and d+Au collisions at sqrt(s_NN) = 200 GeV
We report a measurement of high-p_T inclusive pi^0, eta, and direct photon
production in p+p and d+Au collisions at sqrt(s_NN) = 200 GeV at midrapidity (0
gamma gamma were detected in the
Barrel Electromagnetic Calorimeter of the STAR experiment at the Relativistic
Heavy Ion Collider. The eta -> gamma gamma decay was also observed and
constituted the first eta measurement by STAR. The first direct photon cross
section measurement by STAR is also presented, the signal was extracted
statistically by subtracting the pi^0, eta, and omega(782) decay background
from the inclusive photon distribution observed in the calorimeter. The
analysis is described in detail, and the results are found to be in good
agreement with earlier measurements and with next-to-leading order perturbative
QCD calculations.Comment: 28 pages, 30 figures, 6 tables, the updated version that was accepted
by Phys. Rev.
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