The Capitalist Mode of Power: Second Speaker Series

capital accumulation capitalist mode of power economic growth General Electric hierarchy Hollywood public debtExisting theories of capitalism, mainstream as well as heterodox, view capitalism as a mode of production and consumption. This speaker series interrogates capitalism as a mode of power. The five presentations deal with the past, present and future of the CasP project (Bichler & Nitzan), the historical connection between economic growth and the formation of social hierarchy (Fix), the role of blockbuster cinema in reducing Hollywood's risk (McMahon), the external-internal power dynamics of the U.S. public debt (Hager), and General Electric’s staying power and what can be learned from it for the study of capital accumulation (Cochrane). The speaker series is organized by the Forum on Capital as Power and sponsored by the York Department of Political Science and Graduate Program in SPT. LOCATION: Verney Room, 674 South Ross, Keele Campus (open to all, with refreshments) DATES: October 20, 27; November 3, 10, 17, 2015 TIME: 3:00-5:00 P

Community asset mapping for violence prevention: A comparison of views in Erijaville, South Africa and Memphis, USA

In the context of addressing challenges relating to ongoing interpersonal violence, this article conducts a comparative analysis of findings from a community asset mapping process drawing responses from 100 community participants across the two sites of Erijaville, South Africa and Memphis, Tennessee in the USA. Specifically, we describe the similarities and differences across sites regarding community assets linked to safety and peace promotion, with a particular emphasis on tangible and intangible factors relevant to the promotion of safety and peace. The findings reveal a major emphasis on ‘intangible’ factors that relate to the promotion of safety  and peace, including personal values and behaviour (such as love, compassion and prayer), family relationships (such as family socialisation, care and supervision, role modelling, and peer guidance), and community connectedness (including community hope and trust, and the development of ethical leadership). The findings suggest that religious assets and spiritual capacity constitute important resources, which should be more intentionally mobilised and enhanced to promote safety and peace. This constitutes an important challenge in relation to violence prevention in both South Africa and the USA.Keywords: community-based participatory research, community asset mapping, interpersonal violence, violence prevention, positive forms of masculinity, peace and safety, religious assets, spiritual capacit

Community asset mapping as an action research strategy for developing an interpersonal violence prevention programme in South Africa

The aim of this article was to report and critically reflect on community asset mapping processes used to develop a contextually valid interpersonal violence prevention pro gramme in South Africa to promote positive forms of masculinity, safety and peace. This study was informed by a critical public health framework, and was guided by the values and principles of community-based participatory action research. The research and action methods used included community asset mapping and action planning workshops, workshop evaluation questionnaires and reflexive researcher diary notes. Data were analysed using both qualitative and quantitative methods. The results of this study dem onstrated that the community asset mapping process provides reflexive and embedded spaces for academic and community participants to interactively engage and critically discuss issues which resonate with community concerns, and collectively find possible solutions to challenges identified. A participatory and asset-based approach holds prom ise for developing interventions that are appropriate and relevant to local challengInstitute for Social and Health Studies (ISHS

A Fishery Manager's Guidebook, Second Edition

A Fishery Managers' Guidebook was first published as an FAO Fisheries Technical Paper in 2002 to meet the need for information and guidance on the broad and often complex task of fisheries management. Based on subsequent experience and feedback gained from publication of the first edition, this new volume, has been expanded to provide broader coverage of the key elements of the task and updated in order to keep track of the rapid developments in theory and practice as academics and practitioners struggle to confront the many challenges facing modern fisheries management

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

The Capitalist Mode of Power: Second Speaker Series

Existing theories of capitalism, mainstream as well as heterodox, view capitalism as a mode of production and consumption. This speaker series interrogates capitalism as a mode of power. The five presentations deal with the past, present and future of the CasP project (Bichler & Nitzan), the historical connection between economic growth and the formation of social hierarchy (Fix), the role of blockbuster cinema in reducing Hollywood's risk (McMahon), the external-internal power dynamics of the U.S. public debt (Hager), and General Electric’s staying power and what can be learned from it for the study of capital accumulation (Cochrane). The speaker series is organized by the Forum on Capital as Power and sponsored by the York Department of Political Science and Graduate Program in SPT. LOCATION: Verney Room, 674 South Ross, Keele Campus (open to all, with refreshments) DATES: October 20, 27; November 3, 10, 17, 2015 TIME: 3:00-5:00 P

Identification of small molecule modulators of HIV-1 Tat and Rev protein accumulation

Background: HIV-1 replication is critically dependent upon controlled processing of its RNA and the activities provided by its encoded regulatory factors Tat and Rev. A screen of small molecule modulators of RNA processing identified several which inhibited virus gene expression, affecting both relative abundance of specific HIV-1 RNAs and the levels of Tat and Rev proteins. Results: The screen for small molecules modulators of HIV-1 gene expression at the post-transcriptional level identified three (a pyrimidin-7-amine, biphenylcarboxamide, and benzohydrazide, designated 791, 833, and 892, respectively) that not only reduce expression of HIV-1 Gag and Env and alter the accumulation of viral RNAs, but also dramatically decrease Tat and Rev levels. Analyses of viral RNA levels by qRTPCR and RTPCR indicated that the loss of either protein could not be attributed to changes in abundance of the mRNAs encoding these factors. However, addition of the proteasome inhibitor MG132 did result in significant restoration of Tat expression, indicating that the compounds are affecting Tat synthesis and/or degradation. Tests in the context of replicating HIV-1 in PBMCs confirmed that 791 significantly reduced virus replication. Parallel analyses of the effect of the compounds on host gene expression revealed only minor changes in either mRNA abundance or alternative splicing. Subsequent tests suggest that 791 may function by reducing levels of the Tat/Rev chaperone Nap1. Conclusions: The three compounds examined (791, 833, 892), despite their lack of structural similarity, all suppressed HIV-1 gene expression by preventing accumulation of two key HIV-1 regulatory factors, Tat and Rev. These findings demonstrate that selective disruption of HIV-1 gene expression can be achieved.Medicine, Faculty ofOther UBCNon UBCMedicine, Department ofReviewedFacult

Community asset mapping as an action research strategy for developing an interpersonal violence prevention programme in South Africa

The aim of this article was to report and critically reflect on community asset mapping processes used to develop a contextually valid interpersonal violence prevention programme in South Africa to promote positive forms of masculinity, safety and peace. This study was informed by a critical public health framework, and was guided by the values and principles of community-based participatory action research. The research and action methods used included community asset mapping and action planning workshops, workshop evaluation questionnaires and reflexive researcher diary notes. Data were analysed using both qualitative and quantitative methods. The results of this study demonstrated that the community asset mapping process provides reflexive and embedded spaces for academic and community participants to interactively engage and critically discuss issues which resonate with community concerns, and collectively find possible solutions to challenges identified. A participatory and asset-based approach holds promise for developing interventions that are appropriate and relevant to local challenges.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors wish to acknowledge and thank the National Research Foundation (NRF) (Community Engagement) and the University of South Africa (Community Engagement) for their financial support.Institute for Social and Health Studies (ISHS