5,010 research outputs found

    Multiplicities and tensor product coefficients for ArA_r

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    We apply some recent developments of Baldoni-DeLoera-Vergne on vector partition functions, to Kostant and Steinberg formulas, in the case of ArA_r. We therefore get a fast {\sc Maple} program that computes for ArA_r: the multiplicity cλ,μc_{\lambda,\mu} of the weight μ\mu in the representation V(λ)V(\lambda) of highest weight λ\lambda; the multiplicity cλ,μ,νc_{\lambda,\mu,\nu} of the representation V(ν)V(\nu) in V(λ)V(μ)V(\lambda)\otimes V(\mu). The computation also gives the locally polynomial functions cλ,μc_{\lambda,\mu} and cλ,μ,νc_{\lambda,\mu,\nu}

    Volume computation for polytopes and partition functions for classical root systems

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    This paper presents an algorithm to compute the value of the inverse Laplace transforms of rational functions with poles on arrangements of hyperplanes. As an application, we present an efficient computation of the partition function for classical root systems.Comment: 55 pages, 14 figures. Maple programs available at http://www.math.polytechnique.fr/~vergne/work/IntegralPoints.htm

    Manifolds associated with (Z2)n(Z_2)^n-colored regular graphs

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    In this article we describe a canonical way to expand a certain kind of (Z2)n+1(\mathbb Z_2)^{n+1}-colored regular graphs into closed nn-manifolds by adding cells determined by the edge-colorings inductively. We show that every closed combinatorial nn-manifold can be obtained in this way. When n3n\leq 3, we give simple equivalent conditions for a colored graph to admit an expansion. In addition, we show that if a (Z2)n+1(\mathbb Z_2)^{n+1}-colored regular graph admits an nn-skeletal expansion, then it is realizable as the moment graph of an (n+1)(n+1)-dimensional closed (Z2)n+1(\mathbb Z_2)^{n+1}-manifold.Comment: 20 pages with 9 figures, in AMS-LaTex, v4 added a new section on reconstructing a space with a (Z2)n(Z_2)^n-action for which its moment graph is a given colored grap

    Soigner des migrants précaires en psychiatrie publique

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    Nous vous proposons de partager quelques questionnements à partir d'une étude - en cours - de la Permanence d'accès au(x) soin(s) et de santé (PASS) de l'hôpital du Vinatier à Bron dans le Rhône. Pour cet article nous documentons la problématique du soin des migrants précaires en psychiatrie publique, au regard des spécificités du public et d'un contexte institutionnel particulier

    Pharmacological Or Genetic Targeting Of Transient Receptor Potential (TRP) Channels Can Disrupt The Planarian Escape Response

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    In response to noxious stimuli, planarians cease their typical ciliary gliding and exhibit an oscillatory type of locomotion called scrunching. We have previously characterized the biomechanics of scrunching and shown that it is induced by specific stimuli, such as amputation, noxious heat, and extreme pH. Because these specific inducers are known to activate Transient Receptor Potential (TRP) channels in other systems, we hypothesized that TRP channels control scrunching. We found that chemicals known to activate TRPA1 (allyl isothiocyanate (AITC) and hydrogen peroxide) and TRPV (capsaicin and anandamide) in other systems induce scrunching in the planarian species Dugesia japonica and, except for anandamide, in Schmidtea mediterranea. To confirm that these responses were specific to either TRPA1 or TRPV, respectively, we tried to block scrunching using selective TRPA1 or TRPV antagonists and RNA interference (RNAi) mediated knockdown. Unexpectedly, co-treatment with a mammalian TRPA1 antagonist, HC-030031, enhanced AITC-induced scrunching by decreasing the latency time, suggesting an agonistic relationship in planarians. We further confirmed that TRPA1 in both planarian species is necessary for AITC-induced scrunching using RNAi. Conversely, while co-treatment of a mammalian TRPV antagonist, SB-366791, also enhanced capsaicin-induced reactions in D. japonica, combined knockdown of two previously identified D. japonica TRPV genes (DjTRPVa and DjTRPVb) did not inhibit capsaicin-induced scrunching. RNAi of DjTRPVa/DjTRPVb attenuated scrunching induced by the endocannabinoid and TRPV agonist, anandamide. Overall, our results show that although scrunching induction can involve different initial pathways for sensing stimuli, this behavior’s signature dynamical features are independent of the inducer, implying that scrunching is a stereotypical planarian escape behavior in response to various noxious stimuli that converge on a single downstream pathway. Understanding which aspects of nociception are conserved or not across different organisms can provide insight into the underlying regulatory mechanisms to better understand pain sensation

    Tissue fusion over non-adhering surfaces

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    Tissue fusion eliminates physical voids in a tissue to form a continuous structure and is central to many processes in development and repair. Fusion events in vivo, particularly in embryonic development, often involve the purse-string contraction of a pluricellular actomyosin cable at the free edge. However in vitro, adhesion of the cells to their substrate favors a closure mechanism mediated by lamellipodial protrusions, which has prevented a systematic study of the purse-string mechanism. Here, we show that monolayers can cover well-controlled mesoscopic non-adherent areas much larger than a cell size by purse-string closure and that active epithelial fluctuations are required for this process. We have formulated a simple stochastic model that includes purse-string contractility, tissue fluctuations and effective friction to qualitatively and quantitatively account for the dynamics of closure. Our data suggest that, in vivo, tissue fusion adapts to the local environment by coordinating lamellipodial protrusions and purse-string contractions
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