625 research outputs found
Interplay between lattice, orbital, and magnetic degrees of freedom in the chain-polymer Cu(II) breathing crystals
The chain-polymer Cu(II) breathing crystals C21H19CuF12N4O6 were studied
using the x-ray diffraction and ab initio band structure calculations. We show
that the crystal structure modification at T=146 K, associated with the spin
crossover transition, induces the changes of the orbital order in half of the
Cu sites. This in turn results in the switch of the magnetic interaction sign
in accordance with the Goodenough-Kanamori-Andersen theory of the coupling
between the orbital and spin degrees of freedom.Comment: 6 pages, 7 figure
Obtención de modelos de cálculo de sistemas provisionales de protección de borde mediante la técnica de Análisis Modal Operacional
In this work were obtained by Operational Modal Analysis (OMA) vibration modes and frequencies associated with temporary of protection systems (TEPS) built with planks of pine wood and steel poles. These systems have been evaluated analytically, using a finite element model (FEM). For the FEM we obtained the elastic constants of wood using ultrasound. The results of experimental and analytical assessment in the first vibration modes match in reasonable ways.En este trabajo se han obtenido experimentalmente mediante Análisis Modal Operacional (AMO) los modos de vibración y las frecuencias asociadas de sistemas provisionales de protección de borde (SPPB) fabricados con tablas de madera de pino silvestre y postes de sección tubular de acero. Los mismos sistemas se han evaluado analíticamente, usando un modelo de elementos finitos (MEF). Para el MEF se han obtenido las constantes elásticas de la madera mediante ultrasonidos. Los resultados de la evaluación experimental y analítica concuerdan en los primeros modos de vibración
Influence of phase-diversity image reconstruction techniques on circular polarization asymmetries
Full Stokes filter-polarimeters are key instruments for investigating the
rapid evolution of magnetic structures on the solar surface. To this end, the
image quality is routinely improved using a-posteriori image reconstruction
methods. We analyze the robustness of circular polarization asymmetries to
phase-diversity image reconstruction techniques. We use snapshots of
magneto-hydrodynamical simulations carried out with different initial
conditions to synthesize spectra of the magnetically sensitive Fe I line at
5250.2 A. We degrade the synthetic profiles spatially and spectrally to
simulate observations with the IMaX full Stokes filter-polarimeter. We also
simulate the focused/defocused pairs of images used by the phase-diversity
algorithm for reconstruction and the polarimetric modulation scheme. We assume
that standard optimization methods are able to infer the projection of the
wavefront on the Zernike polynomials with 10% precision. We also consider the
less favorable case of 25% precision. We obtain reconstructed monochromatic
modulated images that are later demodulated and compared with the original
maps. Although asymmetries are often difficult to define in the quiet Sun due
to the complexity of the Stokes V profiles, we show how asymmetries are
degraded with spatial and spectral smearing. The results indicate that,
although image reconstruction techniques reduce the spatial smearing, they can
modify the asymmetries of the profiles, mainly caused by the appearance of
spatially-correlated noise.Comment: 10 pages, accepted for publication in A&
Muerte perinatal: acompañamiento a mujeres y parejas
Objetivo: analizar las intervenciones que llevan a cabo los profesionales para mejorar la atención brindada a las mujeres y a sus parejas ante una pérdida perinatal. Método: es una revisión de la bibliografía internacional publicada en los últimos 10 años sobre intervenciones para mejorar la atención que se brinda a las parejas ante la muerte de un hijo. Resultados: se observa un déficit en la formación de los profesionales sanitarios relacionada con este tema y se identifican nuevas actuaciones cuyo objetivo es mejorar la atención a las parejas. Conclusiones: no podemos concluir que la «creación de recuerdos» mejore los resultados psicosociales, pero sí la información adaptada durante el proceso, y la matrona es la profesional idónea para ello. No obstante, es necesario mejorar la formación y los recursos de los profesionales para poder ofrecer una atención de calidad
Models and Observations of Sunspot Penumbrae
The mysteries of sunspot penumbrae have been under an intense scrutiny for
the past 10 years. During this time, some models have been proposed and
refuted, while the surviving ones had to be modified, adapted and evolved to
explain the ever-increasing array of observational constraints. In this
contribution I will review two of the present models, emphasizing their
contributions to this field, but also pinpointing some of their inadequacies to
explain a number of recent observations at very high spatial resolution. To
help explaining these new observations I propose some modifications to each of
them. These modifications bring those two seemingly opposite models closer
together into a general picture that agrees well with recent 3D
magneto-hydrodynamic simulations.Comment: 9 pages, 1 color figure. Review talk to appear in the proceedings of
the International Workshop of 2008 Solar Total Eclipse: Solar Magnetism,
Corona and Space Weather--Chinese Space Solar Telescope Scienc
Bulk and surface switching in Mn-Fe-based Prussian Blue Analogues
Many Prussian Blue Analogues are known to show a thermally induced phase
transition close to room temperature and a reversible, photo-induced phase
transition at low temperatures. This work reports on magnetic measurements,
X-ray photoemission and Raman spectroscopy on a particular class of these
molecular heterobimetallic systems, specifically on
Rb0.81Mn[Fe(CN)6]0.95_1.24H2O, Rb0.97Mn[Fe(CN)6]0.98_1.03H2O and
Rb0.70Cu0.22Mn0.78[Fe(CN)6]0.86_2.05H2O, to investigate these transition
phenomena both in the bulk of the material and at the sample surface. Results
indicate a high degree of charge transfer in the bulk, while a substantially
reduced conversion is found at the sample surface, even in case of a near
perfect (Rb:Mn:Fe=1:1:1) stoichiometry. Thus, the intrinsic incompleteness of
the charge transfer transition in these materials is found to be primarily due
to surface reconstruction. Substitution of a large fraction of charge transfer
active Mn ions by charge transfer inactive Cu ions leads to a proportional
conversion reduction with respect to the maximum conversion that is still
stoichiometrically possible and shows the charge transfer capability of metal
centers to be quite robust upon inclusion of a neighboring impurity.
Additionally, a 532 nm photo-induced metastable state, reminiscent of the high
temperature Fe(III)Mn(II) ground state, is found at temperatures 50-100 K. The
efficiency of photo-excitation to the metastable state is found to be maximized
around 90 K. The photo-induced state is observed to relax to the low
temperature Fe(II)Mn(III) ground state at a temperature of approximately 123 K.Comment: 12 pages, 8 figure
Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines
Objective: Physicians frequently deviate from guidelines that promote prudent use of antimicrobials. We explored to what extent patient and disease characteristics were associated with compliance with guideline recommendations for three common infections. Methods: In a 1-year prospective observational study, 1,125 antimicrobial prescriptions were analysed for compliance with university hospital guidelines. Results: Compliance varied significantly between and within the groups of infections studied. Compliance was much higher for lower respiratory tract infections (LRTIs; 79%) than for sepsis (53%) and urinary tract infections (UTIs; 40%). Only predisposing illnesses and active malignancies were associated with more compliant prescribing, whereas alcohol/ intravenous drug abuse and serum creatinine levels > 130 mu mol/l were associated with less compliant prescribing. Availability of culture results had no impact on compliance with guidelines for sepsis but was associated with more compliance in UTIs and less in LRTIs. Narrowing initial broad-spectrum antimicrobial therapy to cultured pathogens was seldom practised. Most noncompliant prescribing concerned a too broad spectrum of activity when compared with guideline-recommended therapy. Conclusion: Patient characteristics had only a limited impact on compliant prescribing for a variety of reasons. Physicians seemed to practise defensive prescribing behaviour, favouring treatment success in current patients over loss of effectiveness due to resistance in future patients
Symptom and Quality of Life Improvement in LUX-Lung 8, an Open-Label Phase III Study of Second-Line Afatinib Versus Erlotinib in Patients With Advanced Squamous Cell Carcinoma of the Lung After First-Line Platinum-Based Chemotherapy
INTRODUCTION: In the phase III LUX-Lung 8 trial, afatinib significantly improved progression-free survival (PFS) and overall survival (OS) versus erlotinib in patients with squamous cell carcinoma (SCC) of the lung progressing during or after platinum-based chemotherapy. Patient-reported outcomes (PROs) and health-related quality of life (QoL) in these patients are presented. PATIENTS AND METHODS: Patients (n = 795) were randomized 1:1 to oral afatinib (40 mg/d) or erlotinib (150 mg/d). PROs were collected (baseline, every 28 days until progression, 28 days after discontinuation) using the European Organization for Research and Treatment of Cancer QoL questionnaire and lung cancer-specific module. The percentage of patients improved during therapy, time to deterioration (TTD), and changes over time were analyzed for prespecified lung cancer-related symptoms and global health status (GHS)/QoL. RESULTS: Questionnaire compliance was 77.3% to 99.0% and 68.7% to 99.0% with afatinib and erlotinib, respectively. Significantly more patients who received afatinib versus erlotinib experienced improved scores for GHS/QoL (36% vs. 28%; P = .041) and cough (43% vs. 35%; P = .029). Afatinib significantly delayed TTD in dyspnea (P = .008) versus erlotinib, but not cough (P = .256) or pain (P = .869). Changes in mean scores favored afatinib for cough (P = .0022), dyspnea (P = .0007), pain (P = .0224), GHS/QoL (P = .0320), and all functional scales. Differences in adverse events between afatinib and erlotinib, specifically diarrhea, did not affect GHS/QoL. CONCLUSION: In patients with SCC of the lung, second-line afatinib was associated with improved prespecified disease-related symptoms and GHS/QoL versus erlotinib, complementing PFS and OS benefits with afatinib
Afatinib versus erlotinib as second-line treatment of patients with advanced squamous cell carcinoma of the lung: Final analysis of the randomised phase 3 LUX-Lung 8 trial
Background: LUX-Lung 8 was a randomised, controlled, phase 3 study comparing afatinib and erlotinib as second-line treatment of patients with advanced squamous cell carcinoma (SCC) of the lung. We report the final overall survival (OS) and safety analyses of LUX-Lung 8 and investigate the characteristics of patients who achieved long-term benefit (≥12 months’ treatment). Methods: LUX-Lung 8 (NCT01523587) enroled patients between March 2012 and January 2014 in 183 cancer centres located in 23 countries worldwide and this final analysis had a data cut-off of March 2018. Eligible patients had stage IIIB or IV lung SCC and had progressed after at least four cycles of platinum-based chemotherapy. Patients were randomly assigned (1:1) to receive afatinib (40 mg per day) or erlotinib (150 mg per day) until disease progression. Endpoints included OS and safety; a post-hoc analysis of patients with long-term benefit (≥12 months on treatment) was also conducted. Findings: 795 eligible patients were randomly assigned (398 to afatinib, 397 to erlotinib). OS was significantly prolonged with afatinib compared with erlotinib (median 7·8 months vs 6·8 months; hazard ratio 0·84; 95% CI 0·73–0·97; p = 0·0193). These findings were consistent with those of the primary analysis and were consistent across subgroups. Adverse events (AEs) were manageable with dose interruption and reduction, with similar AEs being experienced between both groups. Twenty-one (5·3%) patients receiving afatinib and 13 (3·3%) patients receiving erlotinib achieved long-term benefit; median OS was 34·6 months and 20·1 months, respectively. Amongst 132 afatinib-treated patients who underwent tumour genetic analysis, ERBB family mutations were more common in patients with long-term benefit than in the overall population (50% vs 21%). Interpretation: Afatinib is a treatment option for patients with SCC of the lung progressing on chemotherapy who are ineligible for immunotherapy, particularly those with ERBB family genetic aberrations. Afatinib has a predictable and manageable tolerability profile, and long-term treatment may be well tolerated
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