Nonsurgical Strategies for the Treatment of Temporomandibular Joint Disorders

Temporomandibular disorders are common maxillofacial disturbs of different etiologies (traumatic, inflammatory, degenerative, or congenital) that course with pain and dysfunctions of the temporomandibular joint. The treatment of these disorders includes systematically administered drugs (especially nonsteroid anti-inflammatory drugs and corticoids), physical therapies, and minimally invasive therapies that require intraarticular injections. These techniques are directed to clean or drain the articular cavity, to deliver intraarticularly drugs, biologically active compounds (as platelet-rich plasma), or to enhance lubrication (hyaluronic acid). Moreover, minimally invasive strategies are used in regenerative medicine for to deliver cells and stem cells, and nano- or micro-biomaterials. Surgery of temporomandibular disorders is only used in grave diseases that require arthrodesis or remotion of the temporomandibular joint. This review updates the nonsurgical therapeutic strategies to treat temporomandibular disorders, focusing the attention in the articular delivery or hyaluronic acid and platelet-rich plasma, two minimally invasive widely used at present

Comparison of hierarchical temporal memories and artificial neural networks under noisy data

The ability of two different machine learning approaches to map non-linear problems from experimental data is evaluated under controlled experiments. A well-known machine learning algorithm (Artificial Neural Network) is compared against a new computing paradigm (Hierarchical Temporal Memory) under a controlled scenario. The chosen scenario is the detection of impacts in a cantilever beam under vibration instrumented with fiber Bragg gratings. The main characteristics of both of the machine learning approaches are analyzed while varying environmental parameters such as the number of sensing points and their location. From the achieved results some clues can be extracted regarding dealing with noisy or partial data using different machine learning approaches

A Comparative Analysis of Conductance Probes and High-Speed Camera Measurements for Interfacial Behavior in Annular Air-Water Flow

[EN] Different techniques are used to analyze annular flow, but the more interesting ones are those techniques that do not perturb the flow and provide enough resolution to clearly distinguish the interfacial phenomena that take place at the interface, especially the disturbance waves (DW) and the ripple waves (DW). The understanding of these events is important because it influences the heat and mass transfer taking place through the thin film formed near the walls in this flow regime. The laser-induced fluorescence (LIF) and the three-electrode conductance probe are two commonly used techniques to study experimentally annular flow phenomena. In this paper, a set of experiments at different temperatures of 20 degrees C, 30 degrees C and 40 degrees C and different liquid Reynolds numbers have been performed in the annular flow regime, the characteristic of the DW and RW as average height and frequency of these waves has been measured by both techniques LIF and conductance probes. In addition, we also measured the mean film thickness. It was found that the mean film thickness and the DW height are practically the same when measured by both techniques; however, the height of the RW is smaller when measured by the conductance probe and this difference diminishes when the temperature increases.This research was funded by the Plan Nacional de I+D, grant number ENE2016-79489-C2-1-P, Ministerio de Economia y Competitividad.Rivera, Y.; Bidon, M.; Muñoz-Cobo, JL.; Berna, C.; Escrivá, A. (2023). A Comparative Analysis of Conductance Probes and High-Speed Camera Measurements for Interfacial Behavior in Annular Air-Water Flow. Sensors. 23(20):1-33. https://doi.org/10.3390/s23208617133232

Sampled Fiber Bragg Grating spectral synthesis

In this paper, a technique to estimate the deformation profile of a Sampled Fiber Bragg Grating (SFBG) is proposed and experimentally verified. From the SFBG intensity reflection spectrum, any arbitrary longitudinal axis deformation profile applied to a SFBG is estimated. The synthesis algorithm combines a custom defined error metric to compare the measured and the synthetic spectra and the Particle Swarm Optimization technique to get the deformation profile. Using controlled deformation profiles, the proposed method has been successfully checked by means of simulated and experimental tests. The results obtained under different controlled cases show a remarkable repetitiveness (< 50 με) and good spatial accuracy (< 1 mm).This work has been supported by the project TEC2010-20224-C02-02 and grant AP2009-1403

Experimental Measurements and CFD Results of Liquid Film Thickness in Vertical Downward Air-Water Annular Flow

[EN] Annular gas¿liquid flows have been extensively studied over the years. However, the nonlinear behavior of the interface is still currently the subject of study by multiple researchers worldwide. The appearance of a liquid layer on the wall and its turbulent behavior support the heat exchange of multiple systems in the industrial field. Research in this area allows the optimization of these installations as well as the analysis of possible safety problems if the liquid film disappears. This study first shows some of the most important findings obtained in the GEPELON experimental facility (GEneración de PElícula ONdulatoria or Wavy Film Generator). The facility was built in order to analyze the behavior of the liquid film in annular downward air¿water flow. The experimental range of the inlet conditions is 800¿8000 for the ReL and 0¿110,000 for the Reg. Measurements for the mean film thickness show a fairly good agreement with the empirical correlations and the measurements of other authors. One of the most demanded applications of this type of measurements is the validation of computational dynamics or CFD codes. Therefore, the experiment has been modeled using Ansys CFX software, and the simulation results have been compared with the experimental ones. This article outlines some of the reasons why two-phase flow simulations are currently challenging and how the codes are able to overcome them. Simulation predictions are fairly close to the experimental measurements, and the mean film thickness evolution when changing the boundary conditions also shows a good agreement.The authors are indebted to the plan of I+D support of the EXMOTRANSIN project ENE2016-79489-C2-1-P.Rivera-Durán, Y.; J. L. Muñoz-Cobo; A. Escrivá; C. Berna; Y. Córdova (2022). Experimental Measurements and CFD Results of Liquid Film Thickness in Vertical Downward Air-Water Annular Flow. International Journal of Computational Methods and Experimental Measurements. 10(2):93-103. https://doi.org/10.2495/CMEM-V10-N2-93-1039310310

The Cutaneous Biopsy for the Diagnosis of Peripheral Neuropathies: Meissner’s Corpuscles and Merkel’s Cells

Cutaneous biopsy is a complementary method, alternative to peripheral nerve biopsy, for the analysis of nerve involvement in peripheral neuropathies, systemic diseases, and several pathologies of the central nervous system. Most of these neuropathological studies were focused on the intraepithelial nerve fibers (thin-myelinated Aδ fibers and unmyelinated C fibers), and few studies investigated the variations in dermal innervation, that is, large myelinated fibers, Merkel’s cell-neurite complexes, and Meissner’s corpuscles. Here, we updated and summarized the current data about the quantitative and qualitative changes that undergo MCs and MkCs in peripheral neuropathies. Moreover, we provide a comprehensive rationale to include MCs in the study of cutaneous biopsies when analyzing the peripheral neuropathies and aim to provide a protocol to study them

Experiments in free falling and downward cocurrent annular flows-Characterization of liquid films and interfacial waves

[EN] Falling liquid films and downward cocurrent flows in rounded shape pipes have been experimentally studied during the last decades, estimating the evolution of its major characteristics. The most important variables during the formation and growth of surface waves in falling downward flows have been measured using conductance probes. The main objective of the current research paper is to study the dependency of the characteristics of the thin liquid layer for downward cocurrent annular flows. The GEPELON experimental facility consists of a vertical pipe with 3.8 m of useful test length. Two pipe diameters have been analysed in this experimental study, 42 and 30 mm, in which the range covered by the liquid Reynolds number varies between 570 and 8500 and 800-7900 respectively, while the gas Reynolds numbers vary from 0 to 7.9.10(4) and from 0 to 1.1.10(5) respectively for the mentioned pipe diameters. Up to five conductance probes have been placed along the pipes test sections to capture the liquid film thickness fluctuations along time at different distances of the pipe entrance for both developing and fully developed regions. After the study and analysis of the experimental data, the central point of this paper has been the development of new correlations for the liquid film thicknesses and the two major properties of the interfacial waves. Their adjustment procedure has been carried out in terms of dimensionless numbers, aiming to provide more general relationships. In particular, the magnitudes that characterise the interface behavior have been measured, particularly film thicknesses, average disturbance wave amplitudes, and disturbance wave frequencies for each boundary condition. An additional part of the document contains an extensive comparison between the results obtained in this study and the data and expressions of other authors. It has been confirmed the significant dispersion existing among different researchers, especially when analysing variables related to the interfacial waves. This highlights the lack of knowledge in some aspects even today. The different correlations proposed have been calculated based on the best fit of the data from all the series of experiments carried out in this study. Comparisons of the behaviour of these correlations with data from other researchers have also been included.This research is supported by the EXMOTRANSIN project ENE2016-79489-C2-1-P included in the I + D Spanish plan. Funding for open access charge: CRUE-Universitat Politècnica de València.Rivera-Durán, Y.; Berna, C.; Muñoz-Cobo, JL.; Escrivá, A.; Córdova, Y. (2022). Experiments in free falling and downward cocurrent annular flows-Characterization of liquid films and interfacial waves. Nuclear Engineering and Design. 392:1-23. https://doi.org/10.1016/j.nucengdes.2022.11176912339