253 research outputs found

    Community, poverty, power: The politics of tribal self-determination, 1960--1968.

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    "Community, Poverty, Power" underscores the need for scholars to transcend conventional definitions of Indian history, combine micro and macro scales of analysis, and blend social and political perspectives. In addition to expanding the interpretive ground upon which the War on Poverty is assessed and suggesting a different way of thinking about the emergence of tribal self-determination, it provides a context for understanding the heightened militancy of the Red Power movement. It also re-envisions the meaning of activism so that it includes people who worked within the system in order to affect change. To the extent that the idea of tribal self-determination entered national discourse between 1960 and 1968, it did so because of these continuing encounters between natives and newcomers."Community, Poverty, Power" explores how tribal self-determination moved from the periphery to the center of the public sphere during the 1960s. Focusing on the Association on American Indian Affairs, National Congress of American Indians, American Indian Chicago Conference, Workshop on American Indian Affairs, and National Indian Youth Council, Part One demonstrates that the struggle against termination and assimilation cannot be understood apart from the global politics of decolonization and domestic contests over race and mass society. Having situated the study in this milieu, Part Two examines the central role the War on Poverty, and particularly the Community Action Program, played in the politics of self-determination after its inauguration in 1964.Based on original manuscript research and interviews with Vine Deloria Jr., Forrest Gerard, Dr. Jim Wilson, and other central actors, these chapters detail the complex series of negotiations regarding the nature of poverty, the meaning of community, and the fate of tribal identities that followed. Two additional chapters focused on Oklahoma, and informed by interviews with LaDonna Harris, Senator Fred R. Harris, Iola Hayden, and others demonstrate the interconnectedness of local people's experiences and the decisions made by national policymakers. The dissertation concludes with a Coda that carries the study forward to the spring of 1968 and the Poor People's Campaign---a pivotal moment that evidenced the limitations of social reform and the impending fragmentation of the Indian rights movement

    Exploring, Celebrating, and Deepening Oceanic Relationalities

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    The theme of the 2018 Oceania Comparative and International Society (OCIES) conference held at Victoria University of Wellington, in Wellington, New Zealand aimed to explore, celebrate, and deepen Oceanic relationalities. This special issue of the International Education Journal: Comparative Perspectives responds to this call for scholarship to examine how Comparative and International Education (CIE) can be repositioned around the notion of relationality to contribute theoretically, practically, and spiritually to education at global, regional, national, and community levels. In this Special Edition, we celebrate the work of seven new and emerging researchers from OCIES. This paper introduces us as a community of scholars, connected geographically by sea, yet it is our shared commitment to relationality that has enabled us to further the scholarship of CIE within our region

    Foot-Ground Reaction Force During Resistance Exercise in Parabolic Flight

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    An interim Resistance Exercise Device (iRED) was designed to provide resistive exercise as a countermeasure to space flight-induced loss of muscle strength and endurance as well as decreased bone mineral density. The purpose of this project was to compare foot-ground reaction force during iRED exercise in normal gravity (l-g) versus micro gravity (O-g) achieved during parabolic flight. METHODS: Four subjects performed three exercises using the iRED (squat, heel raise, and deadlift) during I-g and O-g at a moderate intensity (60% of maximum strength during deadlift exercise). Foot-ground reaction force was measured in three axes (x,y,z) using a force plate, and the magnitude of the resultant force vector was calculated (r = ~X 2 + y2 + Z2 ). Range of motion (ROM) was measured using a linear encoder. Peak force (PkF) and total work (TW) were calculated using a customized computer program. Paired t-tests were used to test if significant differences (p.::::0.05) were observed between I-g and O-g exercise. RESULTS: PkF and TW measured in the resultant axis were significantly less in O-g for each of the exercises tested. During O-g, PkF was 42-46% and TW was 33- 37% of that measured during I-g. ROM and average time to complete each repetition were not different from I-g to O-g. CONCLUSIONS: When performing exercises in which body mass is a portion of the resistance during I-g, PkF and TW measured during resistive exercise were reduced approximately 60-70% during O-g. Thus, a resistive exercise device during O-g will be required to provided higher resistances to induce a similar training stimulus to that on Earth

    The Australian science communicators conference 2020

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    © The Author(s). This special issue of JCOM features six commentary articles from the research stream of the Australian Science Communicators conference, held in February 2020. These opportunistic assessments and deliberate analyses explore important themes of trust, engagement, and communication strategy across a diverse range of scientific contexts. Together, they demonstrate the importance of opportunities to come together and share the research that underpins our practice. The conference and these commentaries enable us to engage in professional development during these exceptional times when successful evidence-based science communication is of critical significance

    How was it for you? Experiences of participatory design in the UK health service

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    Improving co-design methods implies that we need to understand those methods, paying attention to not only the effect of method choices on design outcomes, but also how methods affect the people involved in co-design. In this article, we explore participants' experiences from a year-long participatory health service design project to develop ‘Better Outpatient Services for Older People’. The project followed a defined method called experience-based design (EBD), which represented the state of the art in participatory service design within the UK National Health Service. A sample of participants in the project took part in semi-structured interviews reflecting on their involvement in and their feelings about the project. Our findings suggest that the EBD method that we employed was successful in establishing positive working relationships among the different groups of stakeholders (staff, patients, carers, advocates and design researchers), although conflicts remained throughout the project. Participants' experiences highlighted issues of wider relevance in such participatory design: cost versus benefit, sense of project momentum, locus of control, and assumptions about how change takes place in a complex environment. We propose tactics for dealing with these issues that inform the future development of techniques in user-centred healthcare design

    Design and conduct of 'Xtreme Alps' : a double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude

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    The study of healthy human volunteers ascending to high altitude provides a robust model of the complex physiological interplay that emulates human adaptation to hypoxaemia in clinical conditions. Nitric oxide (NO) metabolism may play an important role in both adaptation to high altitude and response to hypoxaemia during critical illness at sea level. Circulating nitrate and nitrite concentrations can be augmented by dietary supplementation and this is associated with improved exercise performance and mitochondrial efficiency. We hypothesised that the administration of a dietary substance (beetroot juice) rich in nitrate would improve oxygen efficiency during exercise at high altitude by enhancing tissue microcirculatory blood flow and oxygenation. Furthermore, nitrate supplementation would lead to measurable increases in NO bioactivity throughout the body. This methodological manuscript describes the design and conduct of the ‘Xtreme Alps’ expedition, a double-blind randomised controlled trial investigating the effects of dietary nitrate supplementation on acclimatisation to hypobaric hypoxia at high altitude in healthy human volunteers. The primary outcome measure was the change in oxygen efficiency during exercise at high altitude between participants allocated to receive nitrate supplementation and those receiving a placebo. A number of secondary measures were recorded, including exercise capacity, peripheral and microcirculatory blood flow and tissue oxygenation. Results from this study will further elucidate the role of NO in adaption to hypoxaemia and guide clinical trials in critically ill patients. Improved understanding of hypoxaemia in critical illness may provide new therapeutic avenues for interventions that will improve survival in critically ill patients

    Translating a Global Emission-Reduction Framework for Subnational Climate Action: A Case Study from the State of Georgia

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    Subnational entities are recognizing the need to systematically examine options for reducing their carbon footprints. However, few robust and comprehensive analyses are available that lay out how US states and regions can most effectively contribute. This paper describes an approach developed for Georgia—a state in the southeastern United States called “Drawdown Georgia”, our research involves (1) understanding Georgia’s baseline carbon footprint and trends, (2) identifying the universe of Georgia-specific carbon-reduction solutions that could be impactful by 2030, (3) estimating the greenhouse gas reduction potential of these high-impact 2030 solutions for Georgia, and (4) estimating associated costs and benefits while also considering how the solutions might impact societal priorities, such as economic development opportunities, public health, environmental benefits, and equity. We began by examining the global solutions identified by Project Drawdown. The resulting 20 high-impact 2030 solutions provide a strategy for reducing Georgia’s carbon footprint in the next decade using market-ready technologies and practices and including negative emission solutions. This paper describes our systematic and replicable process and ends with a discussion of its strengths, weaknesses, and planned future research

    Berkeley Supernova Ia Program I: Observations, Data Reduction, and Spectroscopic Sample of 582 Low-Redshift Type Ia Supernovae

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    In this first paper in a series we present 1298 low-redshift (z\leq0.2) optical spectra of 582 Type Ia supernovae (SNe Ia) observed from 1989 through 2008 as part of the Berkeley SN Ia Program (BSNIP). 584 spectra of 199 SNe Ia have well-calibrated light curves with measured distance moduli, and many of the spectra have been corrected for host-galaxy contamination. Most of the data were obtained using the Kast double spectrograph mounted on the Shane 3 m telescope at Lick Observatory and have a typical wavelength range of 3300-10,400 Ang., roughly twice as wide as spectra from most previously published datasets. We present our observing and reduction procedures, and we describe the resulting SN Database (SNDB), which will be an online, public, searchable database containing all of our fully reduced spectra and companion photometry. In addition, we discuss our spectral classification scheme (using the SuperNova IDentification code, SNID; Blondin & Tonry 2007), utilising our newly constructed set of SNID spectral templates. These templates allow us to accurately classify our entire dataset, and by doing so we are able to reclassify a handful of objects as bona fide SNe Ia and a few other objects as members of some of the peculiar SN Ia subtypes. In fact, our dataset includes spectra of nearly 90 spectroscopically peculiar SNe Ia. We also present spectroscopic host-galaxy redshifts of some SNe Ia where these values were previously unknown. [Abridged]Comment: 34 pages, 11 figures, 11 tables, revised version, re-submitted to MNRAS. Spectra will be released in January 2013. The SN Database homepage (http://hercules.berkeley.edu/database/index_public.html) contains the full tables, plots of all spectra, and our new SNID template

    Targeted redox inhibition of protein phosphatase 1 by Nox4 regulates eIF2a-mediated stress signaling

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    Source: doi: 10.15252/embj.201592394Phosphorylation of translation initiation factor 2α (eIF2α) attenuates global protein synthesis but enhances translation of activating transcription factor 4 (ATF4) and is a crucial evolutionarily conserved adaptive pathway during cellular stresses. The serine–threonine protein phosphatase 1 (PP1) deactivates this pathway whereas prolonging eIF2α phosphorylation enhances cell survival. Here, we show that the reactive oxygen species‐generating NADPH oxidase‐4 (Nox4) is induced downstream of ATF4, binds to a PP1‐targeting subunit GADD34 at the endoplasmic reticulum, and inhibits PP1 activity to increase eIF2α phosphorylation and ATF4 levels. Other PP1 targets distant from the endoplasmic reticulum are unaffected, indicating a spatially confined inhibition of the phosphatase. PP1 inhibition involves metal center oxidation rather than the thiol oxidation that underlies redox inhibition of protein tyrosine phosphatases. We show that this Nox4‐regulated pathway robustly enhances cell survival and has a physiologic role in heart ischemia–reperfusion and acute kidney injury. This work uncovers a novel redox signaling pathway, involving Nox4–GADD34 interaction and a targeted oxidative inactivation of the PP1 metal center, that sustains eIF2α phosphorylation to protect tissues under stress
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