5,478 research outputs found
Dagga (cannabis) usage among medical students in Johannesburg
Of 1020 undergraduate medical students at the University of the Witwatersrandsurveyed in 1981 as regards attitudes to and patterns of illicit drug use 868 completed the questionnaire; 32,4% had tried dagga (cannabis) and 16,4% were still using the drug. There was a large increase in the number of students using the drug as they advanced through their studies (6% of the 1st-year class as against 24% of the 5th-year class). The timing of dagga use and previous experimentation with habit-forming drugs· are mentioned, and reasons for non-experimentation· and attitudes towards legalization of dagga are analysed
5 year follow up of a hydroxyapatite coated short stem femoral component for hip arthroplasty: a prospective multicentre study
Short stem, uncemented femoral implants for hip arthroplasty are bone conserving achieving stability through initial metaphyseal press-fit and biological fixation. This study aimed to evaluate the survivorship, mid-term function and health related quality of life outcomes in patients who have undergone total hip arthroplasty (THA) with a fully hydroxyapatite coated straight short stem femoral component with up to 5 years follow-up. 668 patients were recruited to a multicentre study investigating the performance of the cementless Furlong Evolution® stem for THA. 137 patients withdrew at various time points. The mean follow-up was 49 months. Clinical (Harris Hip Score (HHS), radiographic and patient-reported outcome measures—Oxford Hip Score (OHS) and EuroQol 5D (EQ-5D), were recorded pre-operatively and at 6 weeks, 6 months, 1 year, 3 year and 5 year follow ups. At 5-year follow-up, 12 patients underwent revision surgery, representing a cumulative revision rate of 1.8%. Median OHS, HHS and EQ5D scores improved significantly: OHS improved from a pre-operative median of 21 (IQR 14–26) to 47 (IQR 44–48) (p < 0.001). HHS improved from 52 (IQR 40–63) to 98 (IQR 92–100) (p < 0.001) and EQ5D improved from 70 (IQR 50–80) to 85 (IQR 75–95) (p < 0.001). This fully HA-coated straight short femoral stem implant demonstrated acceptable mid-term survivorship and delivered substantial improvements in function and quality of life after THA
The personal belief in a just world and domain-specific beliefs about justice at school and in the family: A longitudinal study with adolescents
This article investigates the relationship between the personal belief in a just world (BJW) and domain-specific beliefs about justice and examines how justice cognitions impact on adolescents' development, particularly on their achievement at school and their subjective well-being. A longitudinal questionnaire study with German adolescents aged 14-19 years was conducted over a period of five to eight months. The pattern of results revealed that evaluations of the school climate and of the family climate as being just were two distinct phenomena, both of which impacted on the personal BJW, which in turn affected the domain-specific beliefs about justice. However, the domain-specific beliefs about justice did not impact on each other directly. Moreover, an evaluation of the family climate (but not of the school climate) as being just reduced depressive symptoms, whereas depressive symptoms did not weaken the evaluation of one's family as being just. The evaluation of the school climate as being just improved the grades received in the next school report, whereas the grades received did not affect the justice evaluation of the school climate. Finally, all relationships persisted when controlling for age and gender. In sum, the pattern of findings supports the notion that justice cognitions impact on development during adolescence
The EPICS Software Framework Moves from Controls to Physics
The Experimental Physics and Industrial Control System (EPICS), is an open-source software framework for high-performance distributed control, and is at the heart of many of the world’s large accelerators and telescopes. Recently, EPICS has undergone a major revision, with the aim of better computing supporting for the next generation of machines and analytical tools. Many new data types, such as matrices, tables, images, and statistical descriptions, plus users’ own data types, now supplement the simple scalar and waveform types of the former EPICS. New computational architectures for scientific computing have been added for high-performance data processing services and pipelining. Python and Java bindings have enabled powerful new user interfaces. The result has been that controls are now being integrated with modelling and simulation, machine learning, enterprise databases, and experiment DAQs. We introduce this new EPICS (version 7) from the perspective of accelerator physics and review early adoption cases in accelerators around the world
Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis
The DNA damage response (DDR) comprises multiple functions that collectively preserve genomic integrity and suppress tumorigenesis. The Mre11 complex and ATM govern a major axis of the DDR and several lines of evidence implicate that axis in tumor suppression. Components of the Mre11 complex are mutated in approximately five percent of human cancers. Inherited mutations of complex members cause severe chromosome instability syndromes, such as Nijmegen Breakage Syndrome, which is associated with strong predisposition to malignancy. And in mice, Mre11 complex mutations are markedly more susceptible to oncogene- induced carcinogenesis. The complex is integral to all modes of DNA double strand break (DSB) repair and is required for the activation of ATM to effect DNA damage signaling. To understand which functions of the Mre11 complex are important for tumor suppression, we undertook mining of cancer genomic data from the clinical sequencing program at Memorial Sloan Kettering Cancer Center, which includes the Mre11 complex among the 468 genes assessed. Twenty five mutations in MRE11 and RAD50 were modeled in S. cerevisiae and in vitro. The mutations were chosen based on recurrence and conservation between human and yeast. We found that a significant fraction of tumor-borne RAD50 and MRE11 mutations exhibited separation of function phenotypes wherein Tel1/ATM activation was severely impaired while DNA repair functions were mildly or not affected. At the molecular level, the gene products of RAD50 mutations exhibited defects in ATP binding and hydrolysis. The data reflect the importance of Rad50 ATPase activity for Tel1/ATM activation and suggest that inactivation of ATM signaling confers an advantage to burgeoning tumor cells
Ab Initio Liquid Hydrogen Muon Cooling Simulations with ELMS in ICOOL
This paper presents new theoretical results on the passage of muons through
liquid hydrogen which have been confirmed in a recent experiment. These are
used to demonstrate that muon bunches may be compressed by ionisation cooling
more effectively than suggested by previous calculations.
Muon cooling depends on the differential cross section for energy loss and
scattering of muons. We have calculated this cross section for liquid H2 from
first principles and atomic data, avoiding traditional assumptions. Thence, 2-D
probability maps of energy loss and scattering in mm-scale thicknesses are
derived by folding, and stored in a database. Large first-order correlations
between energy loss and scattering are found for H2, which are absent in other
simulations. This code is named ELMS, Energy Loss & Multiple Scattering. Single
particle trajectories may then be tracked by Monte Carlo sampling from this
database on a scale of 1 mm or less. This processor has been inserted into the
cooling code ICOOL. Significant improvements in 6-D muon cooling are predicted
compared with previous predictions based on GEANT. This is examined in various
geometries. The large correlation effect is found to have only a small effect
on cooling. The experimental scattering observed for liquid H2 in the MUSCAT
experiment has recently been reported to be in good agreement with the ELMS
prediction, but in poor agreement with GEANT simulation.Comment: 6 pages, 3 figure
How to prioritize patients and redesign care to safely resume planned surgery during the COVID-19 pandemic.
AIMS: Restarting planned surgery during the COVID-19 pandemic is a clinical and societal priority, but it is unknown whether it can be done safely and include high-risk or complex cases. We developed a Surgical Prioritization and Allocation Guide (SPAG). Here, we validate its effectiveness and safety in COVID-free sites. METHODS: A multidisciplinary surgical prioritization committee developed the SPAG, incorporating procedural urgency, shared decision-making, patient safety, and biopsychosocial factors; and applied it to 1,142 adult patients awaiting orthopaedic surgery. Patients were stratified into four priority groups and underwent surgery at three COVID-free sites, including one with access to a high dependency unit (HDU) or intensive care unit (ICU) and specialist resources. Safety was assessed by the number of patients requiring inpatient postoperative HDU/ICU admission, contracting COVID-19 within 14 days postoperatively, and mortality within 30 days postoperatively. RESULTS: A total of 1,142 patients were included, 47 declined surgery, and 110 were deemed high-risk or requiring specialist resources. In the ten-week study period, 28 high-risk patients underwent surgery, during which 68% (13/19) of Priority 2 (P2, surgery within one month) patients underwent surgery, and 15% (3/20) of P3 ( three months) groups. Of the 1,032 low-risk patients, 322 patients underwent surgery. Overall, 21 P3 and P4 patients were expedited to 'Urgent' based on biopsychosocial factors identified by the SPAG. During the study period, 91% (19/21) of the Urgent group, 52% (49/95) of P2, 36% (70/196) of P3, and 26% (184/720) of P4 underwent surgery. No patients died or were admitted to HDU/ICU, or contracted COVID-19. CONCLUSION: Our widely generalizable model enabled the restart of planned surgery during the COVID-19 pandemic, without compromising patient safety or excluding high-risk or complex cases. Patients classified as Urgent or P2 were most likely to undergo surgery, including those deemed high-risk. This model, which includes assessment of biopsychosocial factors alongside disease severity, can assist in equitably prioritizing the substantial list of patients now awaiting planned orthopaedic surgery worldwide. Cite this article: Bone Jt Open 2021;2(2):134-140
Urban transportation: Perspectives on mobility and choice
A study of urban transportation systems are presented characterized by intensive scrutiny of many ideas, philosophies, and academic perspectives. This report is intended to communicate some dimensions of the urban transportation problem to the general public
GRB 050408: An Atypical Gamma-Ray Burst as a Probe of an Atypical Galactic Environment
The bright GRB 050408 was localized by HETE-II near local midnight, enabling
an impressive ground-based followup effort as well as space-based followup from
Swift. The Swift data from the X-Ray Telescope (XRT) and our own optical
photometry and spectrum of the afterglow provide the cornerstone for our
analysis. Under the traditional assumption that the visible waveband was above
the peak synchrotron frequency and below the cooling frequency, the optical
photometry from 0.03 to 5.03 days show an afterglow decay corresponding to an
electron energy index of p_lc = 2.05 +/- 0.04, without a jet break as suggested
by others. A break is seen in the X-ray data at early times (at ~12600 sec
after the GRB). The spectral slope of the optical spectrum is consistent with
p_lc assuming a host-galaxy extinction of A_V = 1.18 mag. The optical-NIR
broadband spectrum is also consistent with p = 2.05, but prefers A_V = 0.57
mag. The X-ray afterglow shows a break at 1.26 x 10^4 sec, which may be the
result of a refreshed shock. This burst stands out in that the optical and
X-ray data suggest a large H I column density of N_HI ~ 10^22 cm^-2; it is very
likely a damped Lyman alpha system and so the faintness of the host galaxy (M_V
> -18 mag) is noteworthy. Moreover, we detect extraordinarily strong Ti II
absorption lines with a column density through the GRB host that exceeds the
largest values observed for the Milky Way by an order of magnitude.
Furthermore, the Ti II equivalent width is in the top 1% of Mg II
absorption-selected QSOs. This suggests that the large-scale environment of GRB
050408 has significantly lower Ti depletion than the Milky Way and a large
velocity width (delta v > 200 km/s).Comment: ApJ submitte
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