Akademisyenlerin İş ve Aile Karakteristiklerinin Evlilik, Aile ve Yaşam Tatmini İle İlişkisi: İş ve Aile Çatışmasının Aracı Rolü

The aim of this study was to examine mediator effect of work-family conflict (WFC) on the relationship between within-domain demands and boundary-spanning resources of work-family domain, and marital, family and life satisfaction. Using data gathered from married faculty members with at least one child (n=445) in İstanbul, the present study provided an integrated model combining demands, resources, WFC (work-to-family and family-to-work), family and personal well-being outcomes in a single study. According to results of path analysis, the proposed model explained 26% of the variance in marital satisfaction, 54% of the variance in family satisfaction, and 42% of the variance in life satisfaction. The model suggested that within-domain demands had negative effect on marital, family and life satisfaction through WFC while boundary-spanning resources had positive effect on them through WFC.Bu çalışmanın amacı, akademisyenlerin iş ve aile alanına ilişkin alan içi taleplerinin ve sınır kapsamı kaynaklarının; evlilik, aile ve yaşam tatmini ile ilişkisinde, iş ve aile çatışmasının aracı rolünü saptamaktır. İstanbul daki devlet ve vakıf üniversitelerinde çalışan evli ve çocuklu 445 akademisyen üzerinde yürütülen araştırmada; iş ve aile alanına ilişkin talepler, kaynaklar, iş ve aile çatışması (iş-aile ve aile-iş) ile iş ve aile ilişkisinin aile ve bireysel yaşama yönelik sonuçlarını birleştiren bir model sunulmuştur. Path analizi ile test edilen araştırma modeli, evlilik tatminine ilişkin varyansın %26 sini, aile tatmininin %54 ünü ve yaşam tatminine ilişkin varyansın %42 sini açıklamıştır. Modelden elde edilen sonuçlar, iş ve aile alanına ilişkin alan içi taleplerin, iş ve aile çatışmasını artırıcı; her iki alana yönelik sınır kapsamı kaynakların ise, iş ve aile çatışmasını azaltıcı fonksiyon göstererek; evlilik, aile ve yaşam tatminini artırdığını göstermiştir

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old