Aspergillus Bibliography

This bibliography attempts to cover genetical and biochemical publications on Aspergillus nidulans and also includes selected references to related species and topics

Revised allelism relationships among Aspergillus meth and gal mutants.

Revised allelism relationships among Aspergillus meth and gal mutants

Guido Pontecorvo 1907-1999

Ponte , as he was known, even to his family, died in September 1999, aged 91, of complications following a fall whilst collecting mushrooms in his beloved Swiss mountains. He was the founder of the genetics of Aspergillus nidulans, and as a result of the discovery of the parasexual cycle, the originator of genetical studies in many other fungi. He made significant contributions to modern genetics in elucidating the divisibility of the gene by recombination, and in his later years in the application of parasexual techniques to mammalian cell cultures. He was also an irascible yet genial friend and adviser who attracted the great admiration of colleagues and students worldwide

The ethos of action learning within a virtual Reflective Practice Forum: an account of practice drawing connections between action learning, community of practice and supervision frameworks

As Action Learning has evolved, it has been adapted to promote learning in various contexts. In this account of practice, we share our perspectives as facilitators of the application of action learning principles within Reflective Practice Forums for Mentoring and Coaching Programme Managers. The ethos of action learning was adopted with the forums to enable the programme managers to engage in regular reflections of their current practices and ongoing professional development. In our assessment of the application of action learning principles and processes within the Reflective Practice Forums, we consider the connections between action learning, communities of practice and supervision frameworks to examine and present the ‘ethos’ of Action Learning within the forums

The potential of geospatial technology for monitoring peatland environments

There have been significant advances in the spectral and spatial resolution of data collected from spaceborne, airborne and terrestrial based geospatial technologies over the past 20 years. In sensitive peatland ecosystems, the non-intrusive application of these technologies offers great potential to improve vegetation monitoring and topographical mapping. This paper discusses the potential of geospatial technologies for monitoring vegetation, mapping natural erosion features and assessing artificial drainage with reference to two peatland sites in England. Earth Observation (EO) data can now provide colour imagery with spatial resolution comparable to conventional aerial photography. Enhanced spectral resolution of spaceborne sensors has also increased the accuracy of automated image classification for bog vegetation and EO data may challenge the relevance of conventional aerial photography in landscape-scale assessment. Ultra-high resolution data achievable from Unmanned Aerial Vehicle (UAV) and Terrestrial Laser Scanner (TLS) technologies are providing unprecedented levels of detail from remote sensing. UAV imagery now provides the possibility of identifying individual plants which greatly increases a researcher’s ability to map vegetation from aerial imagery. UAV derived elevation data, combined with the capability of TLS, provide enhanced resolution of gully and artificial drain morphology compared to airborne LiDAR and allow a new approach for quantifying erosion. These technologies provide opportunities to extend traditional surveys over far larger areas than was previously possible and can assist both in targeting areas for future restoration and in monitoring of subsequent change. Traditional survey methods will however maintain an important role in assessing many aspects of peatlands, as they not only provide information to verify remotely sensed data, but are currently the only method that can ‘see’ underneath peatland vegetation

Evaluation of the Induction of Immune Memory following Infant Immunisation with Serogroup C Neisseria meningitidis Conjugate Vaccines - Exploratory Analyses within a Randomised Controlled Trial

Aim: We measured meningococcal serogroup C (MenC)-specific memory B-cell responses in infants by Enzyme-Linked Immunospot (ELISpot) following different MenC conjugate vaccine schedules to investigate the impact of priming on immune memory. Methods: Infants aged 2 months were randomised to receive 1 or 2 doses of MenC-CRM197 at 3 or 3 and 4 months, 1 dose of MenC-TT at 3 months, or no primary MenC doses. All children received a Haemophilus influenzae type b (Hib)-MenC booster at 12 months. Blood was drawn at 5, 12, 12 months +6 days and 13 months of age. Results: Results were available for 110, 103, 76 and 44 children from each group respectively. Following primary immunisations, and prior to the 12-month booster, there were no significant differences between 1- or 2-dose primed children in the number of MenC memory B-cells detected. One month following the booster, children primed with 1 dose MenC-TT had more memory B-cells than children primed with either 1-dose (p = 0.001) or 2-dose (p<0.0001) MenC-CRM197. There were no differences in MenC memory B-cells detected in children who received 1 or 2 doses of MenC-CRM197 in infancy and un-primed children. Conclusions: MenC-specific memory B-cell production may be more dependent on the type of primary vaccine used than the number of doses administered. Although the mechanistic differences between MenC-CRM197 and MenC-TT priming are unclear, it is possible that structural differences, including the carrier proteins, may underlie differential interactions with B- and T-cell populations, and thus different effects on various memory B-cell subsets. A MenC-TT/Hib-MenC-TT combination for priming/boosting may offer an advantage in inducing more persistent antibody.peer-reviewe

A case of Pasteurella multocida peritoneal dialysis-associated peritonitis and review of the literature

AbstractObjectives: Two episodes of peritoneal dialysis-associated peritonitis, which occurred four months apart and were both due to Pasteurella multocida, were noted in a 73 year old woman. This report aims to describe the clinical history of these episodes and the microbiological investigations that were undertaken. The relevant literature will also be discussed.Methods and results: Basic microbiological tests identified the organism as Pasteurella multocida, and further work at a specialist laboratory classified it as Pasteurella multocida subsp. multocida. Pulsed field gel electrophoresis confirmed that the strains isolated from the two clinical episodes originated from the same clone. A literature search was performed, looking particularly for patients who experienced more than one episode of peritonitis caused by Pasteurella spp, whether due to recurrence or re-infection.Conclusions: It is likely that the infection resulted from a domestic cat, as there was evidence of a cat bite to the dialysis tubing in the period between the two episodes. Re-infection with two identical strains of pasteurella is more probable than relapse, for reasons discussed. Strict hygiene and avoiding contact between dialysis tubing and domestic animals must be emphasised to try to prevent pasteurella and other animal-associated infections in this already vulnerable population

Aspergillus nidulans pyrE and pyrF

Sequencing of a gene cloned by complementation of a pyr mutant in Glasgow strain G190 shows this mutant to be pyrE, encoding dihydroorotate dehydrogenase. This discovery necessitates a revision of the genetic map derived from crosses with this strain