Epidemiology of Adverse Drug Reactions

I would like to conclude by citing two rather interesting observations we have made. Three-quarters of all the patients in all our surveillance who have allergic reactions to drugs have had peptic ulcer, ulcerative colitis, or neoplastic disease of the gastrointestinal tract. Of these patients, three-quarters of the drugs producing allergic reactions are administered orally. The rates of allergic reactions to individual drugs in patients with gastrointestinal disease as opposed to those without gastrointestinal disease receiving the same medication, are significantly increased. What the impact is of inflammatory gastrointestinal disease 1) upon the absorption of the drug, 2) upon its metabolism, and 3) upon its antigenicity has not been investigated before. But from these studies it is suggested that inflammatory disease of the gastrointestinal tract may be an important factor predisposing patients receiving oral drugs to occurrence of allergic reactions. It has commonly been supposed that patients with autoimmunological disorders, e.g., system lupus erythematous, may have a predisposition to multiple allergic reactions to drugs. In our evaluation of this problem, there is no significant increase in the occurrence of allergic reactions to drugs in these patients

Middle Mississippian carbonates of the Illinois Basin : a seminar and core workshop, April 23rd and 24th, 1981, Mt. Vernon, Illinois

co-sponsored by the Illinois Geological Society and the Illinois State Geological SurveyOpe

Active Faults in Dam Foundations: An Update

This paper updates the 1974 Geotechnique paper on the same subject by Sherard, Cluff, and Allen. Geologists and seismologists are now able to recognize the presence of, and assess the degree of activity of, faults in dam foundations far more effectively than only a few years ago, thanks to a variety of new neotectonic tools. Similarly, engineers are increasingly able to accept possible foundation displacements with a variety of innovative measures in dam design. Brief case studies of faults beneath dams are presented, and some mitigative measures are described, for Auburn Dam site (USA), Clyde Dam (New Zealand), Eastside Reservoir USA), Lauro Dam (USA), Matahina Dam (New Zealand), Ridgway Dam (USA), Seven Oaks Dam (USA), Steno Dam site (Greece), and Tarbela Dam (Pakistan)

Evidence for Unusually Strong Near-field Ground Motion on the Hanging Wall of the San Fernando Fault during the 1971 Earthquake

Reports of unusually intense ground motions in the very near fields of faults that have ruptured during earthquakes are becoming more common, particularly with the markedly increased worldwide strong-motion instrumentation in recent years (e.g., Heaton and Wald, 1994). The reported ground motions are sufficiently strong to have significant potential engineering impact (Hall et al., 1995). In addition to fault proximity, two other factors that have contributed to unusually high strong motions are rupture directivity (e.g., Somerville et al., 1997) and locations on the hanging walls of thrust faults (e.g., Nason, 1973; Abrahamson and Somerville, 1996; Brune, 1996a; Brune, 1996b). Perhaps nowhere has the sharp distinction between damage on the hanging wall and footwall of a thrust fault been more dramatically documented than during the 1945 Mikawa earthquake, Japan (Iida, 1985)

Potentially Active Faults in Dam Foundations

The Paper contains information on existing dams founded on active faults, a summary of pertinent lessons learned from study of historic fault breaks and fault mechanisms, recommended practice for evaluation of active faults, and opinions concerning design of dams on active faults. While a dam site with an active fault should be avoided if possible, if a reservoir is vitally needed and a better site is not available, it is reasonable practice to construct a conservatively designed embankment dam. Concrete dams on active faults, or near some major active faults, are not advisable. For evaluation of fault activity, geological studies usually must be carried a considerable distance from the dam site, a departure from recent past practice. Experience of the last few years with many fault studies indicates that thorough geological investigations with modern techniques will usually provide sufficient evidence to allow a judgement on the activity or inactivity of a fault

Target structure independent 7Li⃗^7\vec{Li} elastic scattering at low momentum transfers

Analyzing powers and cross sections for the elastic scattering of polarized 7Li by targets of 6Li, 7Li and 12C are shown to depend only on the properties of the projectile for momentum transfers of less than 1.0 fm-1. The result of a detailed analysis of the experimental data within the framework of the coupled channels model with ground state reorientation and transitions to the excited states of the projectile and targets included in the coupling schemes are presented. This work suggests that nuclear properties of weakly-bound nuclei can be tested by elastic scattering experiments, independent of the target used, if data are acquired for momentum transfers less than ~1.0 fm-1.Comment: 9 pages, 4 figures, 1 table, accepted in Phys. Lett.

pp-sdsd shell gap reduction in neutron-rich systems and cross-shell excitations in 20^{20}O

Excited states in $^{20}$O were populated in the reaction $^{10}$Be($^{14}$C,$\alpha$) at Florida State University. Charged particles were detected with a particle telescope consisting of 4 annularly segmented Si surface barrier detectors and $\gamma$ radiation was detected with the FSU $\gamma$ detector array. Five new states were observed below 6 MeV from the $\alpha$-$\gamma$ and $\alpha$-$\gamma$-$\gamma$ coincidence data. Shell model calculations suggest that most of the newly observed states are core-excited 1p-1h excitations across the $N = Z = 8$ shell gap. Comparisons between experimental data and calculations for the neutron-rich O and F isotopes imply a steady reduction of the $p$-$sd$ shell gap as neutrons are added

Alien Registration- Cluff, Roy (Mars Hill, Aroostook County)

https://digitalmaine.com/alien_docs/34073/thumbnail.jp