10 research outputs found
High-Dose Mannose-Binding Lectin Therapy for Ebola Virus Infection
Mannose-binding lectin (MBL) targets diverse microorganisms for phagocytosis and complement-mediated lysis by binding specific surface glycans. Although recombinant human MBL (rhMBL) trials have focused on reconstitution therapy, safety studies have identified no barriers to its use at higher levels. Ebola viruses cause fatal hemorrhagic fevers for which no treatment exists and that are feared as potential biothreat agents. We found that mice whose rhMBL serum concentrations were increased ≥7-fold above average human levels survived otherwise fatal Ebola virus infections and became immune to virus rechallenge. Because Ebola glycoproteins potentially model other glycosylated viruses, rhMBL may offer a novel broad-spectrum antiviral approach
Reviews: Injustice: Why Social Inequality Persists, Creative Community Planning: Transformative Engagement Methods for Working at the Edge, Regional and Urban GIS: A Decision Support Approach
Assay for Identification of Inhibitors for Bacterial MraY Translocase or MurG Transferase
Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase
The Main Pollutants and Their Impacts on Agriculture, Ecosystems and Health
International audienc