Nemaline bodies as unique pathological feature in the course of treated dermatomyositis.

Dermatomyositis was diagnosed on clinical and muscle histological criteria in a 42-year-old woman. Despite treatment, the patient complained of deterioration of her muscle condition. Since her symptoms were discordant with the rest of the data, muscle biopsy was performed and disclosed rod-bearing non-atrophic fibers as the unique and predominant pathological feature. Their significance is examined in this paper

Benefits of Urologic-Dermatologic Consultations for the Diagnosis of Cutaneous Penile Lesions: A Prospective Study

INTRODUCTION: We evaluated the benefits of a specialized consultation created in 2014 for cutaneous penile lesions. MATERIALS AND METHODS: We performed a descriptive prospective study evaluating all patients sent for a monthly urologic-dermatologic consultation at a French university hospital from September 2014 to September 2015 for cutaneous penile lesions. All patients evaluated were included. We collected the demographic data, clinical examination findings, and the proposed diagnosis and treatment for every patient. RESULTS: A total of 27 patients were included; 4 (14.8%) had been referred by a general physician and 23 (85.2%) by a specialist. Cutaneous penile lesions had evolved within 12 months in 15 patients (55.6%). Penile cancer was diagnosed in 5 patients (18.5%), of which 3 were squamous cell carcinoma (11.1%), 1 was metastasis of melanoma (3.7%), and 1 was extramammary Paget disease (3.7%). In addition, 1 patient (3.7%) had a premalignant lesion on a condyloma, 12 (44.4%) had balanitis, 2 (7.4%) had psoriasis lesions, 3 (11.1%) had condylomas, 1 (3.7%) had genital melanosis, and 3 (11.2%) had normal findings. Four patients (16.6%) underwent biopsy, 8 (33.3%) underwent surgery, and 12 (50%) received local treatment. CONCLUSION: The use of urologic-dermatology specialized consultations resulted in encouraging findings. Patients can benefit from multidisciplinary expertise and rapid treatment of various disorders. Thus, it seems important to develop reference centers created specifically for cancerous disease

A 59-Year-Old Woman With Chronic Skin Lesions of the Leg

Diagnosis: Acrodermatitis chronica atrophicans

An unusual giant serpiginous lesion of secondary syphilis.

Syphilis is a worldwide sexually transmitted infection caused by Treponema pallidum subspecies pallidum. Its association with other STIs, including HIV, demands early diagnosis and immediate treatment of patients. We herein report an unusual serpiginous form of secondary syphilis

Contexts, Issues, and Crime: Examining the Dynamics of Rural Life

SOCIAL SCIENTIFIC RESEARCH ON VIOLENCE AGAINST RURAL WOMEN quickly exploded on the scene in the latter part of the last decade, with the bulk of the work being produced in the United States. Certainly, we now have strong empirical evidence showing that rural women in America are at greater risk of experiencing various types of male-to-female violence than are their suburban and urban counterparts. Yet, as is often said, more empirical, theoretical, and policy work is necessary. Following the approach taken by the contributors to the 2011 anthology Violence Against Women and Children: Mapping the Terrain, the main objective of my presentation is to answer what the editors of this volume (J.W. White, M.P. Koss, and A.E. Kazdin) refer to as these “three seemingly simple questions”: What do we know? How do we know it? What are the next steps

Acquisition of a space representation by a naive agent from sensorimotor invariance and proprioceptive compensation

International audienceIn this article, we present a simple agent which learns an internal representation of space without a priori knowledge of its environment, body, or sensors. The learned environment is seen as an internal space representation. This representation is isomorphic to the group of transformations applied to the environment. The model solves certain theoretical and practical issues encountered in previous work in sensorimotor contingency theory. Considering the mathematical description of the internal representation, analysis of its properties and simulations, we prove that this internal representation is equivalent to knowledge of space

The visual word form area: a prelexical representation of visual words in the fusiform gyrus.

International audienceEvent-related fMRI was used to test the hypothesis that the visual word form area in the left fusiform gyrus holds a modality-specific and prelexical representation of visual words. Subjects were engaged in a repetition-detection task on pairs of words or pronounceable pseudo-words that could be written or spoken. The visual word form area responded only to written stimuli, not to spoken stimuli, independently of their semantic content. We propose that the occasional activation of the fusiform gyrus when listening to spoken words is due to the topdown recruitment of visual orthographic or object representations

Prevalence of Candida ciferrii in elderly patients with trophic disorders of the legs36658

In order to define the prevalence of Candida ciferrii in onychomycosis, the fungal biota associated with toe nail onyxis was examined in 50 elderly patients with trophic disorders of the legs and in 220 patients without clinical evidence of trophic disorders. Candida ciferrii was more frequent in the first group of patients since it was recovered from 24% of these patients, whereas its prevalence was only 1.4% in the control group. Moreover, the positivity of the direct examination of toe nail scrapings, the absence of any other associated pathogens, and the repeated isolation of this yeast species for some of the patients confirmed its pathogenicity</p

Cutaneous phaeohyphomycosis due to Alternaria infectoria36745

Here we report a case of cutaneous alternariosis in a 74-year-old man treated by corticotherapy for myasthenia, and presenting with papular, crusted lesions on the left elbow and the right knee. Histological examination of the biopsy specimens showed fungal hyphae associated with round-shaped cells which were highly suggestive of alternariosis. Mycological culture allowed the isolation of a dematiaceous fungus which was identified as a member of the Alternaria infectoria species-group. This was confirmed by PCR amplification and sequencing of the internal transcribed spacer domain of the gene encoding nuclear ribosomal DNA and of the mitochondrial small subunit ribosomal DNA domain. The fungus was therefore referred to the Scientific Institute of Public Health where it was identified as Alternaria infectoria, on the basis of its very small 1 or 2-celled conidia often arranged in long chains and presenting with very long secondary conidiophores. Corticotherapy was stopped and a local antifungal treatment with ketoconazole was initiated, allowing the stabilisation of the cutaneous lesions within 2 months</p