An insight into polarization states of solid-state organic lasers

The polarization states of lasers are crucial issues both for practical applications and fundamental research. In general, they depend in a combined manner on the properties of the gain material and on the structure of the electromagnetic modes. In this paper, we address this issue in the case of solid-state organic lasers, a technology which enables to vary independently gain and mode properties. Different kinds of resonators are investigated: in-plane micro-resonators with Fabry-Perot, square, pentagon, stadium, disk, and kite shapes, and external vertical resonators. The degree of polarization P is measured in each case. It is shown that although TE modes prevail generally (P>0), kite-shaped micro-laser generates negative values for P, i.e. a flip of the dominant polarization which becomes mostly TM polarized. We at last investigated two degrees of freedom that are available to tailor the polarization of organic lasers, in addition to the pump polarization and the resonator geometry: upon using resonant energy transfer (RET) or upon pumping the laser dye to an higher excited state. We then demonstrate that significantly lower P factors can be obtained.Comment: 12 pages, 12 figure

Financial sustainability and profitability of supercritical CO2 pasteurization of liquid products: A case study

This work presents an analysis of a supercritical CO2 (SC-CO2) pasteurization process, focusing on the financial and economic parameters that make the process sustainable at an industrial level. A small company processing 5,000,000 bottles of apple juice per year has been chosen as a case study. Investment and operating costs have been estimated based on data collected from the market and the relevant economic literature. The financial sustainability assessment was performed through the Discounted Cash Flow methodology, proving that SC-CO2 pasteurization is profitable on a 10-year horizon. The Net Present Value is strictly positive and the Internal Rate of Return higher than the cost of funding. The sensitivity analysis shows the robustness of this study to possible changes in the model parameters. Overall, this work demonstrates SC-CO2 pasteurization to be profitable and, considering the current growth of the high-nutritional value fruit juice market, it suggests positive financial returns for both incumbents and new entrants

Solvent effects on Grubbs’ pre-catalyst initiation rates

Initiation rates for Grubbs and Grubbs-Hoveyda second generation pre-catalysts have been measured accurately in a range of solvents. Solvatochromic fitting reveals different dependencies on key solvent parameters for the two pre-catalysts, consistent with different mechanisms by which the Grubbs and Grubbs-Hoveyda pre-catalysts initiate

Analysis and Improvement of the Random Delay Countermeasure of CHES 2009

Random delays are often inserted in embedded software to protect against side-channel and fault attacks. At CHES 2009 a new method for generation of random delays was described that increases the attacker's uncertainty about the position of sensitive operations. In this paper we show that the CHES 2009 method is less secure than claimed. We describe an improved method for random delay generation which does not suffer from the same security weakness. We also show that the paper's criterion to measure the security of random delays can be misleading, so we introduce a new criterion for random delays which is directly connected to the number of acquisitions required to break an implementation. We mount a power analysis attack against an 8-bit implementation of the improved method verifying its higher security in practice

3D radiation therapy boost improves the outcome of whole brain radiation therapy treated RPA II patients with one or two brain metastases

PURPOSE: to evaluate the role of whole brain radiotherapy (WBRT) and radiation boost (RB) for 208 patients recursive partitioning analysis (RPA) II with 1 or 2 brain metastases (BM) at a single institution. METHODS AND MATERIALS: the dose of WBRT was 30 Gy (10 fractions of 3 Gy). One hundred thirty-two patients (63.5%) benefited from RB of 9 Gy in 3 fractions of 3 Gy at the metastatic site. Patients had 1 or 2 BM in 122 (58.7%) and 86 cases (41.3%), respectively. RESULTS: patients with one or two metastases had similar survival (4.6 and 5.1 months, respectively) (p = 0.4). Median overall survival (OS) for patients treated with WBRT and RB, and with WBRT alone was 5.9 and 3.7 months, respectively (p = 0.03). The 6-, 12- and 24-month OS rates after WBRT and RB were 48.5%, 25% and 10.6%, respectively, while WBRT alone resulted in OS rates of 34%, 22.4% and 3.2%, respectively (p = 0.03). After WBRT and RB, the 6-, 12- and 24-month local control rates were 92%, 82% and 67%, respectively, while they were 81.2%, 75% and 37.5%, respectively, after WBRT alone (p = 0.03). The 6-, 12- and 24-month brain control rates after WBRT and RB were 88.7%, 75.8% and 62%, respectively, and after WBRT alone they were 78.5%, 59% and 37.7%, respectively (p = 0.03). CONCLUSION: additional boost delivered with 3D conformal radiotherapy improves local and brain control rates significantly as well as overall survival for RPA II patients with 1 or 2 unresectable BM

Making Password Authenticated Key Exchange Suitable For Resource-Constrained Industrial Control Devices

Connectivity becomes increasingly important also for small embedded systems such as typically found in industrial control installations. More and more use-cases require secure remote user access increasingly incorporating handheld based human machine interfaces, using wireless links such as Bluetooth. Correspondingly secure operator authentication becomes of utmost importance. Unfortunately, often passwords with all their well-known pitfalls remain the only practical mechanism. We present an assessment of the security requirements for the industrial setting, illustrating that offline attacks on passwords-based authentication protocols should be considered a significant threat. Correspondingly use of a Password Authenticated Key Exchange protocol becomes desirable. We review the signif-icant challenges faced for implementations on resource-constrained devices. We explore the design space and shown how we succeeded in tailoring a partic-ular variant of the Password Authenticated Connection Establishment (PACE) protocol, such that acceptable user interface responsiveness was reached even for the constrained setting of an ARM Cortex-M0+ based Bluetooth low-energy transceiver running from a power budget of 1.5 mW without notable energy buffers for covering power peak transients

Echocardiography findings in COVID-19 patients admitted to intensive care units: a multi-national observational study (the ECHO-COVID study)

Purpose: Severely ill patients affected by coronavirus disease 2019 (COVID-19) develop circulatory failure. We aimed to report patterns of left and right ventricular dysfunction in the first echocardiography following admission to intensive care unit (ICU). Methods: Retrospective, descriptive study that collected echocardiographic and clinical information from severely ill COVID-19 patients admitted to 14 ICUs in 8 countries. Patients admitted to ICU who received at least one echocardiography between 1st February 2020 and 30th June 2021 were included. Clinical and echocardiographic data were uploaded using a secured web-based electronic database (REDCap). Results: Six hundred and seventy-seven patients were included and the first echo was performed 2 [1, 4] days after ICU admission. The median age was 65 [56, 73] years, and 71% were male. Left ventricle (LV) and/or right ventricle (RV) systolic dysfunction were found in 234 (34.5%) patients. 149 (22%) patients had LV systolic dysfunction (with or without RV dysfunction) without LV dilatation and no elevation in filling pressure. 152 (22.5%) had RV systolic dysfunction. In 517 patients with information on both paradoxical septal motion and quantitative RV size, 90 (17.4%) had acute cor pulmonale (ACP). ACP was associated with mechanical ventilation (OR > 4), pulmonary embolism (OR > 5) and increased PaCO2. Exploratory analyses showed that patients with ACP and older age were more likely to die in hospital (including ICU). Conclusion: Almost one-third of this cohort of critically ill COVID-19 patients exhibited abnormal LV and/or RV systolic function in their first echocardiography assessment. While LV systolic dysfunction appears similar to septic cardiomyopathy, RV systolic dysfunction was related to pressure overload due to positive pressure ventilation, hypercapnia and pulmonary embolism. ACP and age seemed to be associated with mortality in this cohort

Statistical Ineffective Fault Attacks on Masked AES with Fault Countermeasures

Implementation attacks like side-channel and fault attacks are a threat to deployed devices especially if an attacker has physical access. As a consequence, devices like smart cards and IoT devices usually provide countermeasures against implementation attacks, such as masking against side-channel attacks and detection-based countermeasures like temporal or spacial redundancy against fault attacks. In this paper, we show how to attack implementations protected with both masking and detection-based fault countermeasures by using statistical ineffective fault attacks using a single fault induction per execution. Our attacks are largely unaffected by the deployed protection order of masking and the level of redundancy of the detection-based countermeasure. These observations show that the combination of masking plus error detection alone may not provide sufficient protection against implementation attacks