The BciAi4SLA Project: Towards a User-Centered BCI

The brain–computer interfaces (BCI) are interfaces that put the user in communication with an electronic device based on signals originating from the brain. In this paper, we describe a proof of concept that took place within the context of BciAi4Sla, a multidisciplinary project involving computer scientists, physiologists, biomedical engineers, neurologists, and psychologists with the aim of designing and developing a BCI system following a user-centered approach, involving domain experts and users since initial prototyping steps in a design–test–redesign development cycle. The project intends to develop a software platform able to restore a communication channel in patients who have compromised their communication possibilities due to illness or accidents. The most common case is the patients with amyotrophic lateral sclerosis (ALS). In this paper, we describe the background and the main development steps of the project, also reporting some initial and promising user evaluation results, including real-time performance classification and a proof-of-concept prototype

Interaction of highly nonlinear solitary waves with linear elastic media

We study the interaction of highly nonlinear solitary waves in granular crystals, with an adjacent linear elastic medium. We investigate the effects of interface dynamics on the reflection of incident waves and on the formation of primary and secondary reflected waves. Experimental tests are performed to correlate the linear medium geometry, materials, and mass with the formation and propagation of the reflected waves. We compare the experimental results with theoretical analysis based on the long-wavelength approximation and with numerical predictions obtained from discrete particle models. Studying variations of the reflected wave's velocity and amplitude, we describe how the propagation of primary and secondary reflected waves responds sensitively to the states of the adjacent linear media. Experimental results are found to be in agreement with the theoretical analysis and numerical simulation. This preliminary study establishes the foundation for utilizing reflected solitary waves as novel information carriers in nondestructive evaluation of elastic material systems

Optimized reconstitution of membrane proteins into synthetic membranes

Light-driven proton pumps, such as proteorhodopsin, have been proposed as an energy source in the field of synthetic biology. Energy is required to power biochemical reactions within artificially created reaction compartments like proto-or nanocells, which are typically based on either lipid or polymer membranes. The insertion of membrane proteins into these membranes is delicate and quantitative studies comparing these two systems are needed. Here we present a detailed analysis of the formation of proteoliposomes and proteopolymersomes and the requirements for a successful reconstitution of the membrane protein proteorhodopsin. To this end, we apply design of experiments to provide a mathematical framework for the reconstitution process. Mathematical optimization identifies suitable reconstitution conditions for lipid and polymer membranes and the obtained data fits well to the predictions. Altogether, our approach provides experimental and modeling evidence for different reconstitution mechanisms depending on the membrane type which resulted in a surprisingly similar performance

Outcomes of pregnancies after kidney transplantation: lessons learned from CKD. A comparison of transplanted, nontransplanted chronic kidney disease patients and low-risk pregnancies: a multicenter nationwide analysis.

BACKGROUND: Kidney transplantation (KT) may restore fertility in CKD. The reasons why materno-foetal outcomes are still inferior to the overall population are only partially known. Comparison with the CKD population may offer some useful insights for management and counselling.Aim of this study was to analyse the outcomes of pregnancy after KT, compared with a large population of non-transplanted CKD patients and with low-risk control pregnancies, observed in Italy the new millennium. METHODS: We selected 121 live-born singletons after KT (Italian study group of kidney in pregnancy, national coverage about 75%), 610 live-born singletons in CKD and 1418 low-risk controls recruited in 2 large Italian Units, in the same period (2000-2014). The following outcomes were considered: maternal and foetal death; malformations; preterm delivery; small for gestational age baby (SGA); need for the neonatal intensive care unit (NICU); doubling of serum creatinine or increase in CKD stage. Data were analysed according to kidney diseases, renal function (staging according to CKD-EPI), hypertension, maternal age, partity, ethnicity. RESULTS: Materno-foetal outcomes are less favourable in CKD and KT as compared with the low-risk population. CKD stage and hypertension are important determinants of results. KT patients with e-GFR >90 have worse outcomes compared with CKD stage 1 patients; the differences level off when only CKD patients affected by glomerulonephritis or systemic diseases ('progressive CKD') are compared with KT. In the multivariate analysis, risk for preterm and early-preterm delivery was linked to CKD stage (2-5 versus 1: RR 3.42 and 3.78) and hypertension (RR 3.68 and 3.16) while no difference was associated with being a KT or a CKD patient. CONCLUSIONS: The materno-foetal outcomes in patients with kidney transplantation are comparable with those of nontransplanted CKD patients with similar levels of kidney function impairment and progressive and/or immunologic kidney diseas

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Towards a model of strategic roster planning and control : an empirical study of nurse rostering practices in the UK National Health Service

Despite the criticality of nurse rostering practices, there is a surprising lack of attention paid to this managerial activity both in practice and in the health-service management literature. This paper reports the results of an inductive, empirical study of rostering practices in the UK National Health Service with a view to developing a shared understanding of roster planning processes and of what constitutes rostering effectiveness. A survey of rostering practices in 50 wards, followed by five in-depth, longitudinal case studies, revealed the complexity of rostering activities, and identified the main design parameters, which were used to specify rostering systems and to prepare periodic rosters. Rostering activities were perceived to directly impact upon service delivery, resource utilization and nurse retention. A number of poor rostering practices were identified, which could lead to dysfunctional behaviour. This analysis points to a clear managerial imperative to improve local competencies in roster planning and control, recognizing their strategic significance in contributing to hospital effectiveness. A ‘Strategic Roster Planning and Control (SRPC)’ model is proposed, which may provide a framework for evaluating rostering effectiveness, and a platform for the sharing of best practice, in order to stimulate organizational learning and achieve nationwide improvements in hospital performance

New service design in the NHS : an evaluation of the strategic alignment of NHS Direct

Awareness of inconsistencies and variability in the delivery of health services across the UK has heightened in recent years, leading to general acknowledgement that a move away from "health care by post code" is a strategic priority for the National Health Service (NHS). NHS Direct, a cad centre service for patients and their carers, is unique in the NHS in that it represents an entirely new service concept, with a rare opportunity to design a single nation-wide service from scratch, and to manage and co-ordinate a delivery system-consistently throughout the country. Evaluates the strategic alignment of NHS Direct during the first three years of implementation through an analysis of its service concept, its operational objectives, the design of its delivery systems and its volume and variety characteristics. The evaluation repeals an absence of a central design specification which has resulted in wide variation in the call centres' service portfolios, resource bases; competences, telephony and clinical expert system-Contends that variation and variability in the design of the call centres has severely compromised NHS Direct's ability to meet its strategic and operational objectives, resulting in strategic misalignment Also identifies missed opportunities to learn from the growing call centre literature and from service shops in other industries

An evaluation of nurse rostering practices in the National Health Service

The scheduling of nursing time on hospital wards is critical to the delivery of patient care, resource utilization and employee satisfaction. Over the past decade many hospital wards in the United Kingdom (UK) have moved away from the traditional planning of rosters by a single manager, towards more participative processes known as self-rostering and team rostering. This paper tests the hypothesis, developed from the literature, that the three types of rostering approach may be positioned along a continuum. Self-rostering at one extreme, is conducive to staff empowerment, motivation and roster effectiveness, whilst departmental rostering, at the other, leads to perceived autocracy, reduced empowerment, lower levels of staff motivation and roster effectiveness. Team rostering is positioned mid-way on this continuum. This paper reports the findings of an empirical study of nurse rostering practices in the UK National Health Service (NHS), with a view to developing an understanding of the implications of implementing these three rostering approaches and testing the above hypothesis. The survey of rostering practices in 50 NHS wards, and in-depth case studies of seven wards, revealed that each of the three rostering approaches has benefits and limitations and a picture emerges quite different from that implied by the research hypothesis. Whilst the literature suggests that the choice of rostering approach determines the level of perceived autocracy, staff motivation and roster effectiveness, it is proposed in this paper that selection of rostering approach should be contingent upon operational context. The paper concludes with a framework which stipulates that the choice of rostering approach for a ward should be determined on the basis of four contingent variables, namely, ward size, demand variability, demand predictability, and complexity of skill mix. It is recommended that departmental rostering be applied in large wards with complex rostering problems, whilst team rostering is more appropriate for medium sized wards, and self-rostering appropriate for small wards