7 research outputs found
TCT-153 Safety and efficacy of transendocardial injection of mesenchymal and induced pluripotent stem cells in a swine subacute model of myocardial ischemia
- Author
- Publication venue
- Published by Elsevier Inc.
- Publication date
- 16/09/2014
- Field of study
Delayed administration of allogeneic cardiac stem cell therapy for acute myocardial infarction could ameliorate adverse remodeling: experimental study in swine
- Author
- A Leri
- AR Chugh
- AR Williams
- AW Heldman
- B Dawn
- B Levine
- C Dubois
- C Kubal
- Claudia Baez-Diaz
- E Tseliou
- Fei Sun
- FGP Welt
- Francisco M. Sanchez-Margallo
- G Ellison
- GL Kukielka
- GM Ellison
- GM Ellison
- HC Quevedo
- HD White
- I Chimenti
- Itziar Palacios
- J Bartunek
- Javier G. Casado
- JD Richardson
- JH Houtgraaf
- Jose L. Abad
- Juan Maestre
- K Malliaras
- K Malliaras
- K Malliaras
- KH Schuleri
- KH Schuleri
- KW Kelley
- L Lauden
- Luis Rodriguez-Borlado
- M Bujak
- M Gnecchi
- M Gnecchi
- M Nichols
- Monica Garcia-Lindo
- MW Irwin
- PM Ridker
- PV Johnston
- R Bolli
- R Bolli
- R Silva de
- R-K Li
- Rebeca Blazquez
- RR Makkar
- S Dimmeler
- S Redondo
- SJ Jansen Lorkeers
- SY Lim
- T Freyman
- TIG Spoel van der
- V Crisostomo
- V Crisostomo
- V Karantalis
- V SchÀchinger
- VBC Crisostomo
- Veronica Crisostomo
- Y Wang
- Y-J Yang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
TCT-153 Safety and efficacy of transendocardial injection of mesenchymal and induced pluripotent stem cells in a swine subacute model of myocardial ischemia
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Personalized tissue-engineered veins â long term safety, functionality and cellular transcriptome analysis in large animals
- Author
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Tissue engineering is a promising methodology to produce advanced therapy medicinal products (ATMPs). We have developed personalized tissue engineered veins (P-TEV) as an alternative to autologous or synthetic vascular grafts utilized in reconstructive vein surgery. Our hypothesis is that individualization through reconditioning of a decellularized allogenic graft with autologous blood will prime the tissue for efficient recellularization, protect the graft from thrombosis, and decrease the risk of rejection. In this study, P-TEVs were transplanted to vena cava in pig, and the analysis of three veins after six months, six veins after 12 months and one vein after 14 months showed that all P-TEVs were fully patent, and the tissue was well recellularized and revascularized. To confirm that the ATMP product had the expected characteristics one year after transplantation, gene expression profiling of cells from P-TEV and native vena cava were analyzed and compared by qPCR and sequencing. The qPCR and bioinformatics analysis confirmed that the cells from the P-TEV were highly similar to the native cells, and we therefore conclude that P-TEV is functional and safe in large animals and have high potential for use as a clinical transplant graft.CC BY 3.0First published 13 Apr [email protected] study was supported by Vinnova project CAMP (contract no. 2017-02130), a common call by VINNOVA and VetenskapsrĂ„det: Biologcal pharmaseuticals (Dnr 2017-02983), by University of Skövde under grants from the Swedish Knowledge Foundation [#2016-0330, #2020-0014] and VĂ€stra Götalandsregionen (consultant check). The company VERIGRAFT AB holds a patent on peripheral whole blood perfusion of decellularized tissues and did also finance the project. We want to acknowledge the staff at the Department of Experimental Biomedicine at Gothenburg University. The swine studies in Spain were conducted by the ICTS âNANBIOSISâ, specifically Units 21, 22, and 24 of the CCMIJU. Graphical Abstract image created with BioRender.com.</p
Allogeneic cardiac stem cell administration for acute myocardial infarction
- Author
- Anversa P
- Barile L
- Barile L
- Barnett BP
- Barzelay A
- Bearzi C
- Bearzi C
- Beltrami AP
- Bolli R
- Carr CA
- Cheng K
- Chimenti I
- Chugh AR
- Claudia Baez-Diaz
- Di Felice V
- Di Felice V
- Dimmeler S
- Dixon JA
- Edling CE
- Ellison G
- Ellison GM
- Ellison GM
- Ellison GM
- Fonoudi H
- Francisco M Sanchez-Margallo
- Fuentes T
- Gaetani R
- Galvez-Monton C
- Gambini E
- Garcia-Castro J
- Gnecchi M
- Gnecchi M
- Go AS
- Goichberg P
- Gomez-Mauricio RG
- Goodell MA
- Grinnemo KH
- Hare JM
- Holmes C
- Hong K
- Houtgraaf JH
- Huang XP
- Javier G Casado
- Jezierska-Wozniak K
- Johnston PV
- Kami D
- Koninckx R
- Koudstaal S
- Kraitchman DL
- Kreke M
- Kubal C
- Lai RC
- Lauden L
- Lee S-T
- Leri A
- Li T-S
- Li Z
- Maguire G
- Makkar RR
- Malliaras K
- Malliaras K
- Malliaras K
- Matsuura K
- Mohsin S
- Monnet E
- Nadal-Ginard B
- Nichols M
- Oh H
- Oskouei BN
- Rebeca Blazquez
- Sanz-Ruiz R
- Smith RR
- Suzuki Y
- Suzuki Y
- Takehara N NM
- Tomita Y
- Tseliou E
- van de Rijn M
- Veronica Crisostomo
- Welt FGP
- Williams AR
- Yang Y-J
- Yarden Y
- Yee K
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer
- Author
- Abdi Ehtesham
- Abraham Jean
- Abreu Miguel
- Adams Sylvia
- Aktan G.
- Al Baghdadi Tareq
- Allerton Rozenn
- Allison Magnuson
- Altena Renske
- AlĂ©s MartĂnez Jose Enrique
- Anampa Mesias Jesus
- Andreopoulou Eleni
- Ansari Bilal
- Antill Yoland
- Aogi Kenjiro
- Aragones Antonia Marquez
- Arahmani A.
- Armstrong A.C.
- Armstrong Anne
- Armstrong Deborah
- Armstrong Deborah
- Arnedos M.
- Arrick Bradley
- Asaad Shonda
- Aydogdu Mustafa
- Baez-Diaz Luis
- Bahadur Shakeela
- Bakker Sandra
- Balmaña J.
- Barrett Sophie
- Bartsch Rupert
- Bañuelos Juan Cueva
- Bear Harry
- Bechtner Christina
- Bella Santiago
- Bergh J.
- Bermejo de las Heras Begoña
- Bernardo Antonio
- BertrĂĄn Ana Santaballa
- Bianchini Giampaolo
- Biganzoli Laura
- Blajman Cesar
- Bliss J.
- Boadle David
- Bobolis Kristie
- Bonetti Andrea
- Bordeleau Louise
- Borges Virginia
- Borley Annabel
- Borms Marleen
- Borrego Manuel Ruiz
- Boyle L.E.
- Braga Sofia
- Brain Etienne
- Braybrooke Jeremy
- Brescia Frank
- Brufsky A.M.
- Brufsky Adam
- Bucci Eraldo
- Burhani Nafisa
- Busch Steffi
- Cameron D.
- Campbell C.
- Cannon George
- Cannon George
- Canon Jean-Luc
- Cao MarĂa GonzĂĄlez
- Cardoso Catarina
- Cardoso FĂĄtima
- Carlson Jay
- Carlson Jay
- Carney Jennifer Fu
- Carrasco Fernando Henao
- Casa-Nova Mafalda
- Cescon Terrence
- Chacón López-Muñiz José Ignacio
- Chae Yee Soo
- Chakiba-Brugere Camille
- Chalchal Haji
- Chan Stephen
- Chang Brian
- Chang Yuan-Ching
- Charles William
- Chen Shang-Hung
- Chen Shin-Cheh
- Chen Shou-Tung
- Chiu Chang-Fang
- Cho Eun Kyung
- Chowdhury Nabila
- Chung Wei-Pang
- Ciccarese Mariangela
- Ciruelos Gil Eva MarĂa
- Cobleigh Melody
- Cole John
- Cole John
- Cole John
- Cole John
- Colleoni M.A.
- Colleoni Marco
- Company JesĂșs Alarcon
- Conejero Raquel Andrés
- Conibear John
- Constanzo Maria Victoria
- Conte Pierfranco
- Copson Ellen
- Copur Mehmet
- Cortesi Laura
- Cortijo LucĂa GonzĂĄlez
- Cretella Elisabetta
- Cristofanilli Massimo
- Crusades Gema Llort
- Cui K.
- Curtit Elsa
- Dakhil Shaker
- Dakhil Shaker
- Dalivoust Philippe
- Darsow Maren
- Dayao Zoneddy
- de Boer Maaike
- de la Haba Juan
- de Laurentiis Michelino
- Decker Thomas
- Dedes Konstantin
- Delaloge S.
- Delaloge Suzette
- Delgado Mingorance Juan Ignacio
- Deming Richard
- Denittis Albert
- Deryal Mustafa
- Desbiens Christine
- Deveras Ruby Anne E.
- Dewar Joanna
- Dewitz Thomas
- Dieterich Max
- Domchek S.M.
- Domchek Susan
- Doster John
- Doyle Thomas
- Duhoux François
- Durna Lara
- Egle Daniel
- Einhorn Harvey
- Eisen A.
- Eisen Andrea
- Eisenberg Peter
- Ellis Robert
- Elsafy F.
- Emde Till-Oliver
- Erdkamp Franciscus
- Estevez Laura GarcĂa
- Extra Jean-Marc
- Faller Bryan
- Fan Z.
- Fan Zhimin
- Fasching Peter
- Fehm Tanja
- Fein L.E.
- Fein Luis
- Ferrario Cristiano
- Ferrero Jean-Marc
- Feusner James
- Fielding A.
- Flaum Lisa
- Flynn Patrick
- Flynn Patrick
- Ford J.M.
- Forstmeyer Dirk
- Friday Bret E.B.
- Friedlander Michael
- Friedman S.
- Fu Peifen
- Fuchs David
- Ganz Patricia
- Garber J.E.
- Garber Judy
- Garber Judy
- GarcĂa SĂĄenz JosĂ© Ăngel
- Gayle Arlene
- Gebbia Vittorio
- Gelber R.D.
- Gelmon K.A.
- Gelmon Karen
- Gelpi Judith Balmaña
- Geng Cuizhi
- George Mathew
- Gerds Aaron
- Geyer C.E.
- Giacchetti Sylvie
- Gianni L.
- Gianni Lorenzo
- Gil Amaryllis
- Gnant M.
- Gomez Elena Ălvarez
- GonzĂĄlez-Santiago Santiago
- Goodwin Annabel
- Gori Stefania
- Grafe Andrea
- Graffunder Gerd
- Gratet Alain
- Greil Richard
- Grischke Eva Maria
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gross Howard
- Gröll Isolde
- Göhring Uwe-Jochen
- Hackmann John
- Hahn Antje
- Hahn Olwen
- Hallbeck Anna-Lotta
- Hanson David
- Harbeck Nadia
- Hardy-Bessard Anne-Claire
- Harkness Cameron
- Haslbauer Ferdinand
- Hauke Ralph
- Hauke Ralph
- Hayward Richard
- Heibl Sonja
- Heijns Joan
- Heinrich Bernhard
- Helfgott Ruth
- Herbolsheimer Pia
- Hesse Tobias
- Hickish Tamas
- Hilton Christie
- Hoffmann Oliver
- Hofstatter Erin
- Hofstatter Erin
- Hofstatter Erin
- Hollingsworth S.J.
- Hoskins Kent
- Hou Ming-Feng
- Huang Chiun-Sheng
- Huober Jens
- Hurwitz Jane
- Huynh Chanh
- Huzarski Tomasz
- Höffkes Heinz-Gert
- Im S.-A.
- Im Seock-Ah
- Isaacs Claudine
- Ishida Kazushige
- Ito Mitsuya
- Iwata Hiroji
- Jackisch Christian
- Jacot William
- Jager A.
- Jager Agnes
- Janni W.
- Jañez Noelia MartĂnez
- Jegannathen Apurna
- Jens-Uwe Blohmer Jan Schröder
- Jerusalem Guy
- Jiang Zefei
- JimĂ©nez Miguel MartĂn
- Johannsson Oskar
- Jones Catherine
- Jones Cheryl
- Joris Sofie
- Joshi Abhishek
- Jubelirer Steven
- Julian Thomas
- Jung K.H.
- Jung Kyung Hae
- Jurado Josefina Cruz
- JĂłhannsson Ă. Ă
- Kaen Diego
- Kalinka Ewa
- Kalra Maitri
- Kannourakis George
- Karwal Mark
- Kast Karin
- Kaufman B.
- Kaufman Bella
- Kelleher Muireann
- Khosla Pam
- Kim Jee Hyun
- Kinoshita Takayuki
- Klare Peter
- Kolberg Hans-Christian
- Korde L.
- Krabisch Petra
- Kroep Judith
- Kurian Sobha
- Kuzma Charles
- KĂŒhn Thorsten
- KĂŒmmel Sherko
- KĂŒmmel Sherko
- l'Haridon Tiffenn
- Lakhani S.R.
- Lambiase Elyse
- Landherr LĂĄszlĂł
- Lanza Angels Arcusa
- Lazzaro Mauricio FernĂĄndez
- Ledwon Peter
- Lee Keun Seok
- Lee Kyoung Eun
- Lerzo Guillermo
- Lescure Ălvaro RodrĂguez
- Leu Kirsten M.H.
- Levine Edward
- Levitt Nicola
- Liao Ning
- Linderholm B.
- Linderholm Barbro
- Liu T.-W.
- Lo Shelly
- Loibl S.
- Loman N.
- Loman Niklas
- Lortholary Alain
- Lu Min
- Lu Min
- Lucas P.C.
- Luce Sylvie
- LĂ©vy Christelle
- LĂłpez Isabel Ălvarez
- Mackey John
- Mackiewicz Jacek
- Mahtani Reshma
- Mahtani Reshma
- Mailliez A.
- Mailliez Audrey
- Mansoor Abdul
- Marcom Paul
- Marmé F.
- Martinez de Dueñas E.
- Martinez Lourdes Calvo
- MartĂnez de Dueñas Eduardo
- Masuda Norikazu
- Mau Christine
- Mccarron Edward
- Mccarthy Nicole
- Mcconnell R.
- Mege Alice
- Meisel Jane
- Menter Alex
- Merkel Douglas
- Mita Monica
- Molins Agusti Barnadas
- Mosconi Anna Maria
- Mouret-Reynier Marie-Ange
- Mukai Hirofumi
- Murillo SerafĂn Morales
- Murray Nicholas
- MĂŒller Volkmar
- Nagy T.
- Nagy TĂŒnde
- Nakamura Rikiya
- Nakamura Seigo
- Nakayama Takahiro
- Nangia Julie
- Naoi Yasuto
- Nave MĂłnica
- Neven Patrick
- Niraula Saroj
- Noeding Stefanie
- Noesselt Thomas
- Novak Urban
- Nowecki Zbigniew
- O'Connor Brian
- Ochoa Augusto
- Ochoa Augusto
- Ofori Samuel
- Olabisi Foluso
- Oliff Ira
- Openshaw Thomas
- Openshaw Thomas
- Openshaw Thomas
- Ortega Adela FernĂĄndez
- Ortega Ana Laura
- Osaki Akihiko
- PadrĂł Josep GumĂ
- Paepke Stefan
- Pang D.
- Pang Da
- Papadimitriou Konstantinos
- Park Y.H.
- Park Yeon Hee
- Park-Simon Tjoung-Won
- Parton M.
- Parton Marina
- Pasterk Claudia
- Patel Tejal
- Patocskai Erica
- Penzinger Monika
- Perren Timothy
- Perrin Christophe
- Petit Thierry
- Phillips K.-A.
- Phillips Kelly-Anne
- Piccart M.
- Pilnik Norma
- Pinotti Graziella
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Polikoff Jonathan
- Potenberg Jochem
- Pottier Virginie
- Prady Catherine
- Pristauz-Telsnigg Gunda
- Puthillath Ajithkumar
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Qamar Rubina
- Quaghebeur Claire
- Quiroga Vanesa
- Raben Adam
- Radford James
- Rai Yoshiaki
- Ramaswamy Bhuvaneswari
- Rastogi P.
- Rautenberg Beate
- Razaq W.
- Razaq Wajeeha
- Rea Daniel
- Reeder Jennifer
- Rhiem Kerstin
- Riseberg David
- Robin Erwin
- RodrĂguez CĂ©sar
- Rohatgi Nitin
- Rom Joachim
- Roodenbeke DaphnĂ© Tâkint De
- Ross L.
- Rossi G.
- Rovito Marc
- Roylance Rebecca
- Ruddy Kathryn
- Ruggeri Enzo Maria
- Rumpold Holger
- Ryan Matthew
- Salat Christoph
- Salkeni Mohamad
- Sami Amer
- Santisteban Marta
- Sarosiek Tomasz
- Sato Nobuaki
- Schallenkamp John
- Schmatloch Sabine
- Schmidt M.
- Schmidt Marcus
- Schmutzler R.
- Schott Anne
- Schreiber Carsten
- Seaward Samantha
- Seaward Samantha
- Seeger Grant
- Senkus E.
- Senkus ElĆŒbieta
- Sevelda Paul
- Shao Z.
- Shao Zhimin
- Sharma P.
- Sharma Priyanka
- Sharma Ruby
- Shen Kunwei
- Shenk Robert
- Shenk Robert
- Shenk Robert
- Siegel Robert
- Siggelkow Wulf
- Sigurdson Elin
- Silander Gustav
- Simon HĂ©lĂšne
- Simon Michael
- Singer C.F.
- Singer Christian
- Smith Ron
- Sohn Joo Hyuk
- Song Chuangui
- Sonke G.S.
- Sonke Gabe
- Soori Gamini
- Specht Jennifer
- Spector David
- Steen Preston
- Stefek Andrea
- Stickeler E.
- Stickeler Elmar
- Stockham Abigail
- Storniolo Anna M.V.
- Strasser-Weippl Kathrin
- Stöger Herbert
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Suga J. Marie
- Sugimoto Takeki
- Sui Xingwei
- Sumida Kenneth N.M.
- Sumida Kenneth N.M.
- Sumrall Bradley
- Sun Q.
- Sun Qiang
- SĆowiĆska Anna
- T Benjamin
- Taboada M.
- Takada Masahiro
- Takahashi Masato
- Takano Toshimi
- Tan Antoinette
- Tato-Varela Sara
- Telli Melinda
- Tennevet I.
- Tennevet Isabelle
- Terhaag JĂŒrgen
- Thiel Irene
- Thomalla Jörg
- Thomssen Christoph
- Tiley Susan
- Tinchon Christoph
- Tio Joke
- Tkaczuk Katherine H.R.
- Toi M.
- Tokuda Yutaka
- Tokunaga Eriko
- Tomé Oliver
- Tondini Carlo
- Toppmeyer Deborah
- Tormo Salvador Blanch
- Torres Antonio AntĂłn
- Toyama Tatsuya
- Traina T.A.
- Tredan Olivier
- Trehan Shruti
- Tseng Ling-Ming
- Tsugawa Koichiro
- Tutt A.N.J.
- Tutt Andrew
- Uleer Christoph
- Unnikrishnan Madhu
- Urquhart Alexander
- Uziely Beatrice
- Vachhani Hetal
- Vakhariya Cynthia
- Valdes-Albini Frances
- van der Westhuizen Andre
- van Haelst Carol
- Vanderwoude Amy
- Varadarajan Ramya
- Varela Mirta
- Venat-Bouvet Laurence
- Verusio Claudio
- Viale G.
- Villaró Gemma Viñas
- Virani Shamsuddin
- Vogel Victor
- von Wachenfeldt VĂ€ppling Anna
- Wade James
- Wade James
- Wagner Harald
- Waisman James
- Wang Shui
- Wang Yongsheng
- Watanabe Junichiro
- Weigel Michael
- Weltermann Angsar
- Weniger Steffi
- Wette Viktor
- Wilbur Deborah
- Wilkinson Mary
- Winter Matthew
- Wolf SĂŒtterlin Marc
- Wong Derrick
- Wong Lucas
- Wood Marie
- Wood Marie
- Woodward Natasha
- WĂŒllner Michaela Penelope
- Xu Binghe
- Yamauchi Hideko
- Yan Fengting
- Yanagita Yasuhiro
- Yang H.
- Yang Hongjian
- Yeh Dah-Cherng
- Yerushalmi R.
- Yerushalmi Rinat
- Yothers G.
- Yu Jyh-Cherng
- Zahm Dirk
- Zakalik Dana
- Zamagni Claudio
- Zaman Khalil
- Zarba Juan Jose
- Zera Richard
- Zera Richard
- Zhang J.
- Zhang Jin
- Zheng Hong
- Zhuo Ying
- Zimbler Harvey
- Zoppoli G.
- Ăhler Leopold
- Ć paniÄ T.
- Publication venue
- Elsevier
- Publication date
- 01/12/2022
- Field of study
International audienc
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
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- Vijayagopal Kesav Aditya
- Vijayan Varun
- Vilain Luciano Ferreira
- Villa Gianluca
- Villalobos Santiago
- Villarino-Villa Laura
- Vino Smila
- Viola Marcelo
- Viscosi Francesca
- Vishnoi Jeewan Ram
- Vlad Catalin
- Volkoviene Gerda
- Volturo Lino
- Vural Ummuhan
- VĂĄzquez-FernĂĄndez Andrea
- VĂ€yrynen Antti
- Wagdy Michael
- Waha James
- Waheed Mariam
- Waindeskar Vaishali
- Wakkaf Habib
- Walsh Adam
- WalÄdziak Maciej
- Wang Jaw Yuan
- Wani Rauf
- Wanshantha Dinamulla
- Waqar Usama
- Ward Nicholas
- Watanabe Jun
- Wells Johanna
- Westzaan Natalia
- Wickramarathne Rasika
- Wickramasinghe Dakshitha
- Widatalla Abu Bakr H
- Widyaningsih Rizky
- Wijenayake Wasantha
- Wilson Jeremy
- Wilson Kasmira
- Windels An
- Witjes Caroline
- Wong Siew Ching
- Woodward Andrew
- Wright Deborah
- Wright Jonathan
- Wu Scott
- WÄ troba Anna
- Xanthis Athanasios
- Xavier Ruben
- Xenaki Sofia
- Xynos Evangelos
- Yadav Ram Kishan
- Yadev I P
- Yague Julio
- Yakout Nadia
- Yakunina Natalia
- Yalkin Ămer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)