Document Delivery and Resource Sharing: Global Perspectives

This publication is intended to provide librarians, library practitioners, as well as teachers, researchers, and students of universities and research organizations and other interested parties, a foundation in resource sharing principles, practices and management. This publication provides an overview of where things stand today with resource sharing, including key trends, challenges, opportunities, and priorities. The publication seeks to address international resource sharing, exploring the current state of European and international resource sharing systems and the governing laws and regulations and includes case studies and best practices from various countries

Cross-cutting principles for planetary health education

Since the 2015 launch of the Rockefeller Foundation Lancet Commission on planetary health,1 an enormous groundswell of interest in planetary health education has emerged across many disciplines, institutions, and geographical regions. Advancing these global efforts in planetary health education will equip the next generation of scholars to address crucial questions in this emerging field and support the development of a community of practice. To provide a foundation for the growing interest and efforts in this field, the Planetary Health Alliance has facilitated the first attempt to create a set of principles for planetary health education that intersect education at all levels, across all scales, and in all regions of the world—ie, a set of cross-cutting principles

Digital possibilities in international interlibrary lending:with or despite German copyright law

The German interlibrary loan service is a good and solid basic solution for the supply of literature between libraries within Germany and some other countries. It has proven itself both nationally and internationally. But in what form will it be needed in the future? Which digital possibilities does it offer our users regarding delivery or electronic media? Copyright law in Germany promises to have the right answers to the demands of modern digital working and studying. But does the copyright law also make this possible for German interlibrary lending? German libraries have the advantage that only a few countries worldwide have a copyright that contains a special section for interlibrary lending, and Germany is one of them. However, this positive effect does not make it easier for foreign libraries

Document Delivery and Resource Sharing

Cette publication a été réalisée dans le cadre du projet HERMES, qui vise à fournir aux établissements d’enseignement un accès de haute qualité, rapide et gratuit à la connaissance. La capacité à mettre en œuvre et à partager une vision globale et des compétences étendues sur le partage des ressources accompagné d’un système open source pour favoriser un accès efficace à la connaissances pour tous est ainsi visé

Personalized peptide vaccine-induced immune response associated with long-term survival of a metastatic cholangiocarcinoma patient

Background & AimsWe report a novel experimental immunotherapeutic approach in a patient with metastatic intrahepatic cholangiocarcinoma. In the 5year course of the disease, the initial tumor mass, two local recurrences and a lung metastasis were surgically removed. Lacking alternative treatment options, aiming at the induction of anti-tumor T cells responses, we initiated a personalized multi-peptide vaccination, based on in-depth analysis of tumor antigens (immunopeptidome) and sequencing.MethodsTumors were characterized by immunohistochemistry, next-generation sequencing and mass spectrometry of HLA ligands.ResultsAlthough several tumor-specific neo-epitopes were predicted in silico, none could be validated by mass spectrometry. Instead, a personalized multi-peptide vaccine containing non-mutated tumor-associated epitopes was designed and applied. Immunomonitoring showed vaccine-induced T cell responses to three out of seven peptides administered. The pulmonary metastasis resected after start of vaccination showed strong immune cell infiltration and perforin positivity, in contrast to the previous lesions. The patient remains clinically healthy, without any radiologically detectable tumors since March 2013 and the vaccination is continued.ConclusionsThis remarkable clinical course encourages formal clinical studies on adjuvant personalized peptide vaccination in cholangiocarcinoma.Lay SummaryMetastatic cholangiocarcinomas, cancers that originate from the liver bile ducts, have very limited treatment options and a fatal prognosis. We describe a novel therapeutic approach in such a patient using a personalized multi-peptide vaccine. This vaccine, developed based on the characterization of the patient’s tumor, evoked detectable anti-tumor immune responses, associating with long-term tumor-free survival