Finding a Spherically Symmetric Cosmology from Observations in Observational Coordinates -- Advantages and Challenges

One of the continuing challenges in cosmology has been to determine the large-scale space-time metric from observations with a minimum of assumptions -- without, for instance, assuming that the universe is almost Friedmann-Lema\^{i}tre-Robertson-Walker (FLRW). If we are lucky enough this would be a way of demonstrating that our universe is FLRW, instead of presupposing it or simply showing that the observations are consistent with FLRW. Showing how to do this within the more general spherically symmetric, inhomogeneous space-time framework takes us a long way towards fulfilling this goal. In recent work researchers have shown how this can be done both in the traditional Lema\^{i}tre-Tolman-Bondi (LTB) 3 + 1 coordinate framework, and in the observational coordinate (OC) framework. In this paper we investigate the stability of solutions, and the use of data in the OC field equations including their time evolution and compare both approaches with respect to the singularity problem at the maximum of the angular-diameter distance, the stability of solutions, and the use of data in the field equations. This allows a more detailed account and assessment of the OC integration procedure, and enables a comparison of the relative advantages of the two equivalent solution frameworks. Both formulations and integration procedures should, in principle, lead to the same results. However, as we show in this paper, the OC procedure manifests certain advantages, particularly in the avoidance of coordinate singularities at the maximum of the angular-diameter distance, and in the stability of the solutions obtained. This particular feature is what allows us to do the best fitting of the data to smooth data functions and the possibility of constructing analytic solutions to the field equations.Comment: 31 page

The Metric of the Cosmos from Luminosity and Age Data

This paper presents the algorithm for determining the Lemaitre-Tolman (LT) model that best fits given datasets for maximum stellar ages, and SNIa luminosities, both as functions of redshift. It then applies it to current cosmological data. Special attention must be given to the handling of the origin, and the region of the maximum diameter distances. As with a previous combination of datasets (galaxy number counts and luminosity distances versus redshift), there are relationships that must hold at the region of the maximum diameter distance, which are unlikely to be obeyed exactly by real data. We show how to make corrections that enable a self-consistent solution to be found. We address the questions of the best way to approximate discrete data with smooth functions, and how to estimate the uncertainties of the output - the 3 free functions that determine a specific LT metric. While current data does not permit any confidence in our results, we show that the method works well, and reasonable LT models do fit with or without a cosmological constant.Comment: 25 pages, 8 figures; matches published versio

The Dynamics of Brane-World Cosmological Models

Brane-world cosmology is motivated by recent developments in string/M-theory and offers a new perspective on the hierarchy problem. In the brane-world scenario, our Universe is a four-dimensional subspace or {\em brane} embedded in a higher-dimensional {\em bulk} spacetime. Ordinary matter fields are confined to the brane while the gravitational field can also propagate in the bulk, leading to modifications of Einstein's theory of general relativity at high energies. In particular, the Randall-Sundrum-type models are self-consistent and simple and allow for an investigation of the essential non-linear gravitational dynamics. The governing field equations induced on the brane differ from the general relativistic equations in that there are nonlocal effects from the free gravitational field in the bulk, transmitted via the projection of the bulk Weyl tensor, and the local quadratic energy-momentum corrections, which are significant in the high-energy regime close to the initial singularity. In this review we discuss the asymptotic dynamical evolution of spatially homogeneous brane-world cosmological models containing both a perfect fluid and a scalar field close to the initial singularity. Using dynamical systems techniques it is found that, for models with a physically relevant equation of state, an isotropic singularity is a past-attractor in all orthogonal spatially homogeneous models (including Bianchi type IX models). In addition, we describe the dynamics in a class of inhomogeneous brane-world models, and show that these models also have an isotropic initial singularity. These results provide support for the conjecture that typically the initial cosmological singularity is isotropic in brane-world cosmology.Comment: Einstein Centennial Review Article: to appear in CJ

The Physics of Star Cluster Formation and Evolution

© 2020 Springer-Verlag. The final publication is available at Springer via https://doi.org/10.1007/s11214-020-00689-4.Star clusters form in dense, hierarchically collapsing gas clouds. Bulk kinetic energy is transformed to turbulence with stars forming from cores fed by filaments. In the most compact regions, stellar feedback is least effective in removing the gas and stars may form very efficiently. These are also the regions where, in high-mass clusters, ejecta from some kind of high-mass stars are effectively captured during the formation phase of some of the low mass stars and effectively channeled into the latter to form multiple populations. Star formation epochs in star clusters are generally set by gas flows that determine the abundance of gas in the cluster. We argue that there is likely only one star formation epoch after which clusters remain essentially clear of gas by cluster winds. Collisional dynamics is important in this phase leading to core collapse, expansion and eventual dispersion of every cluster. We review recent developments in the field with a focus on theoretical work.Peer reviewe

Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

The role of two sediment-dwelling invertebrates on the mercury transfer from sediments to the estuarine trophic web

The annual total and organic mercury bioaccumulation pattern of Scrobicularia plana and Hediste diversicolor was assessed to evaluate the potential mercury transfer from contaminated sediments to estuarine food webs. S. plana was found to accumulate more total and organic mercury than H. diversicolor, up to 0.79 mg kg-1 and 0.15 mg kg-1 (wet weight) respectively, with a maximum annual uptake of 0.21 mg kg-1 y-1, while for methylmercury the annual accumulation was similar between species and never exceeded 0.045 mg kg-1 y-1. The higher organic mercury fraction in H. diversicolor is related to the omnivorous diet of this species. Both species increase methylmercury exposure by burrowing activities and uptake in anoxic, methylmercury rich sediment layers. Integration with the annual biological production of each species revealed mercury incorporation rates that reached 28 [mu]g m-2 y-1, and to extract as much as 11.5 g Hg y-1 (of which 95% associated with S. plana) in the 0.4 km2 of the most contaminated area, that can be transferred to higher trophic levels. S. plana is therefore an essential vector in the mercury biomagnification processes, through uptake from contaminated sediments and, by predation, to transfer it to economically important and exploited estuarine species.http://www.sciencedirect.com/science/article/B6WDV-4RT4XSB-1/1/99cc738eb589636060fbbdf4f36ad92