83 research outputs found
Isolating signatures of major cloud-cloud collisions - II. The lifetimes of broad bridge features
This article has been accepted for publication in Monthly Notices of the Royal Astronomical Society. © 2015 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society.We investigate the longevity of broad bridge features in position–velocity diagrams that appear as a result of cloud–cloud collisions. Broad bridges will have a finite lifetime due to the action of feedback, conversion of gas into stars and the time-scale of the collision. We make a series of analytic arguments with which to estimate these lifetimes. Our simple analytic arguments suggest that for collisions between clouds larger than R ∼ 10 pc the lifetime of the broad bridge is more likely to be determined by the lifetime of the collision rather than the radiative or wind feedback disruption time-scale. However, for smaller clouds feedback becomes much more effective. This is because the radiative feedback time-scale scales with the ionizing flux Nly as R7/4N−1/4ly R7/4Nly−1/4 so a reduction in cloud size requires a relatively large decrease in ionizing photons to maintain a given time-scale. We find that our analytic arguments are consistent with new synthetic observations of numerical simulations of cloud–cloud collisions (including star formation and radiative feedback). We also argue that if the number of observable broad bridges remains ∼ constant, then the disruption time-scale must be roughly equivalent to the collision rate. If this is the case, our analytic arguments also provide collision rate estimates, which we find are readily consistent with previous theoretical models at the scales they consider (clouds larger than about 10 pc) but are much higher for smaller clouds.Peer reviewe
Understanding preventive behaviors among mid-Western African-American men: a pilot qualitative study of prostate screening
http://dx.doi.org/10.1016/j.jomh.2011.03.00
The properties of the ISM in disc galaxies with stellar feedback
We perform calculations of isolated disc galaxies to investigate how the
properties of the ISM, the nature of molecular clouds, and the global star
formation rate depend on the level of stellar feedback. We adopt a simple
physical model, which includes a galactic potential, a standard cooling and
heating prescription of the ISM, and self gravity of the gas. Stellar feedback
is implemented by injecting energy into dense, gravitationally collapsing gas,
but is independent of the Schmidt-Kennicutt relation. We obtain fractions of
gas, and filling factors for different phases of the ISM in reasonable ageement
with observations. Supernovae are found to be vital to reproduce the scale
heights of the different components of the ISM, and velocity dispersions. The
GMCs formed in the simulations display mass spectra similar to the
observations, their normalisation dependent on the level of feedback. We find
~40 per cent of the clouds exhibit retrograde rotation, induced by cloud-cloud
collisions. The star formation rates we obtain are in good agreement with the
observed Schmidt-Kennicutt relation, and are not strongly dependent on the star
formation efficiency we assume, being largely self regulated by the feedback.
We also investigate the effect of spiral structure by comparing calculations
with and without the spiral component of the potential. The main difference
with a spiral potential is that more massive GMCs are able to accumulate in the
spiral arms. Thus we are able to reproduce massive GMCs, and the spurs seen in
many grand design galaxies, even with stellar feedback. The presence of the
spiral potential does not have an explicit effect on the star formation rate,
but can increase the star formation rate indirectly by enabling the formation
of long-lived, strongly bound clouds.Comment: 19 pages, 23 figures, accepted by MNRA
Children’s Gender Identity in Lesbian and Heterosexual Two-Parent Families
This study compared gender identity, anticipated future heterosexual romantic involvement, and psychosocial adjustment of children in lesbian and heterosexual families; it was furthermore assessed whether associations between these aspects differed between family types. Data were obtained in the Netherlands from children in 63 lesbian families and 68 heterosexual families. All children were between 8 and 12 years old. Children in lesbian families felt less parental pressure to conform to gender stereotypes, were less likely to experience their own gender as superior and were more likely to be uncertain about future heterosexual romantic involvement. No differences were found on psychosocial adjustment. Gender typicality, gender contentedness and anticipated future heterosexual romantic involvement were significant predictors of psychosocial adjustment in both family types
Simulation of Ionic Surfaces from an Absolutely Convergent Solution of the Madelung Problem
The classic Madelung problem is cast into an absolutely convergent form that is readily evaluated by direct lattice summation, revealing a net r{sup {minus}5} range of the net Coulomb potential in ionic crystals and liquids. The realization that Coulomb interactions in condensed systems can actually be rather short ranged (provided the system is overall neutral) leads to the prediction, verified by computer simulations for rocksalt-structure surfaces, that all surfaces in predominantly ionic crystals should be fundamentally reconstructed. The work also provides a conceptual framework for the theoretical treatment of polar surfaces, as demonstrated for the case of the (111) surfaces of NaCl and MgO
Closing the gap on causal processes of infection risk from cross-sectional data: structural equation models to understand infection and co-infection
Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial
Background
Previous evidence supports androgen deprivation therapy (ADT) with primary radiotherapy as initial treatment for intermediate-risk and high-risk localised prostate cancer. However, the use and optimal duration of ADT with postoperative radiotherapy after radical prostatectomy remains uncertain.
Methods
RADICALS-HD was a randomised controlled trial of ADT duration within the RADICALS protocol. Here, we report on the comparison of short-course versus long-course ADT. Key eligibility criteria were indication for radiotherapy after previous radical prostatectomy for prostate cancer, prostate-specific antigen less than 5 ng/mL, absence of metastatic disease, and written consent. Participants were randomly assigned (1:1) to add 6 months of ADT (short-course ADT) or 24 months of ADT (long-course ADT) to radiotherapy, using subcutaneous gonadotrophin-releasing hormone analogue (monthly in the short-course ADT group and 3-monthly in the long-course ADT group), daily oral bicalutamide monotherapy 150 mg, or monthly subcutaneous degarelix. Randomisation was done centrally through minimisation with a random element, stratified by Gleason score, positive margins, radiotherapy timing, planned radiotherapy schedule, and planned type of ADT, in a computerised system. The allocated treatment was not masked. The primary outcome measure was metastasis-free survival, defined as metastasis arising from prostate cancer or death from any cause. The comparison had more than 80% power with two-sided α of 5% to detect an absolute increase in 10-year metastasis-free survival from 75% to 81% (hazard ratio [HR] 0·72). Standard time-to-event analyses were used. Analyses followed intention-to-treat principle. The trial is registered with the ISRCTN registry, ISRCTN40814031, and
ClinicalTrials.gov
,
NCT00541047
.
Findings
Between Jan 30, 2008, and July 7, 2015, 1523 patients (median age 65 years, IQR 60–69) were randomly assigned to receive short-course ADT (n=761) or long-course ADT (n=762) in addition to postoperative radiotherapy at 138 centres in Canada, Denmark, Ireland, and the UK. With a median follow-up of 8·9 years (7·0–10·0), 313 metastasis-free survival events were reported overall (174 in the short-course ADT group and 139 in the long-course ADT group; HR 0·773 [95% CI 0·612–0·975]; p=0·029). 10-year metastasis-free survival was 71·9% (95% CI 67·6–75·7) in the short-course ADT group and 78·1% (74·2–81·5) in the long-course ADT group. Toxicity of grade 3 or higher was reported for 105 (14%) of 753 participants in the short-course ADT group and 142 (19%) of 757 participants in the long-course ADT group (p=0·025), with no treatment-related deaths.
Interpretation
Compared with adding 6 months of ADT, adding 24 months of ADT improved metastasis-free survival in people receiving postoperative radiotherapy. For individuals who can accept the additional duration of adverse effects, long-course ADT should be offered with postoperative radiotherapy.
Funding
Cancer Research UK, UK Research and Innovation (formerly Medical Research Council), and Canadian Cancer Society
Investigation and analysis into device optimization for attaining efficiencies in-excess of 90% when accounting for higher harmonics
On the continuity of high efficiency modes in linear RF power amplifiers
A novel formulation for the voltage waveforms in high efficiency linear power amplifiers is described. This formulation demonstrates that a constant optimum efficiency and output power can be obtained over a continuum of solutions by utilizing appropriate harmonic reactive impedance terminations. A specific example is confirmed experimentally. This new formulation has some important implications for the possibility of realizing broadband >10% high efficiency linear RF power amplifiers
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